ANALYSIS OF SERUM IRON AND HEAMOGLOBIN LEVEL IN PATIENTS WITH ORAL SUBMUCOUS FIBROSIS
AbstractBackground: OSMF is chronic underlying disease. The disease is well recognized and had an importance due to high malignant transformation rate. Multiple etiological factors are found responsible in the pathogenesis of the disease course. The effect of areca-nut is mainly causing trismus of the oral cavity. This may compromise the food intake of the patients who are facing this precancerous disease. Method: Total one hundred and 28 patients were selected and equally distributed into two groups. It is an observational, cross- sectional study. Sixty four patient with OSMF were selected on the basis of fibrous band formation and mouth opening. The etiological factors such as chewing habit had been denoted in forms. The heamoglobin and iron levels were analyzed from laboratory using automated machines used for blood analysis. Results: The OSMF group showed insignificant variation when the two groups were compared. Whereas the sub-groups of OSMF are showing moderately significant correlation for the serum iron and heamoglobin levels. The outcome of the present study emphases on the assessment of heamoglobin and serum iron for OSMF patients. The patients must be prescribed with the micronutrients therapy so that any deficiency which may contribute in the disease course can be intercepted at the beginning. Further the patients must be educated in term of quitting the chewing habit so that his/ her life not get compromised due to OSMF.
Pindborg JJ, Sirsat SM. Oral submucous fibrosis. Oral Surg Oral Med Oral Pathol 1966;22(6):764–79.
Ramanathan K. Oral submucous fibrosis--an alternative hypothesis as to its causes. Med J Malaysia 1981;36(4):243–5.
Tan SH, Liu Q, Xie Z, Qin MZ, Jia YF, Fu HJ. Effect of Areca catechu extracts on immunity functions and antioxidant activities in mice. Sci Tech Food Indust 2015;2015(17):62.
Hazarey V, Erlewad DM, Mundhe KA, Ughade SN. Oral submucous fibrosis: study of 1000 cases from central India. J Oral Pathol Med 2007;36(1):12–7.
Mishra A, Meherotra R. Head and neck cancer: global burden and regional trends in India. Asian Pac J Cancer Prev 2014;15(2):537–50.
Ray J, Ghosh R, Mallick D, Swain N, Gandhi P, Ram S, at al. Correlation of trace elemental profiles in blood samples of Indian patients with leukoplakia and oral submucous fibrosis. Biol Trace Elem Res 2011;144(1-3):295–305.
Haider SM, Merchant AT, Fikree FF, Rahbar MH. Clinical and functional staging of oral submucous fibrosis. Br J Oral Maxillofac Surg 2000;38(1):12–5.
Ranganathan K, Devi MU, Joshua E, Kirankumar K, Saraswathi TR. Oral submucous fibrosis: a case‐control study in Chennai, South India. J Oral Pathol Med 2004;33(5):274–7.
Khan HM. Evaluation of Serum Copper (Cu), Serum Iron (Fe) and Serum Copper (Cu)/Iron (Fe) Ratio in Oral Submucous Fibrosis in Karachi. J Adv Med Med Res 2018;9:1–9.
Thakur M, Guttikonda VR. Estimation of Hemoglobin, serum iron, total iron-binding capacity and serum ferritin levels in oral submucous fibrosis: A clinicopathological study. J Oral Maxillofac Pathol 2017;21(1):30–5.
Rupak S, Baby GG, Padiyath S, Kumar KR. Oral submucous fibrosis and iron deficiency anemia relationship revisited-results from an Indian study. J Dent 2012;2(2):159–65.
Hegde K, Gharote H, Nair P, Agarwal K, Saawarn N, Kalyanpur D. Iron deficiency in oral submucous fibrosis: accelerator or a promoter? Group 2012;60(11.9):1–43.
Ganapathy KS, Gurudath S, Balikai B, Ballal S, Sujatha D. Role of iron deficiency in oral submucous fibrosis: An initiating or accelerating factor. J Indian Acad Oral Med Radiol 2011;23(1):25.
Bhardwaj D, Dinkar AD, Satoskar SK, Desai SR. Serum iron and haemoglobin estimation in oral submucous fibrosis and iron deficiency anaemia: a diagnostic approach. J Clin Diagn Res 2016;10(12):ZC54–8.
Karthik H, Nair P, Gharote HP, Agarwal K, Ramamurthy Bhat G, Kalyanpur Rajaram D. Role of hemoglobin and serum iron in oral submucous fibrosis: A clinical study. ScientificWorldJournal 2012;2012:25013.
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