THE COMPARISON OF EFFICACY BETWEEN LOSARTAN AND DILTIAZEM AS ANTIPROTEINURIC AGENT IN NON-DIABETIC RENAL DISEASES

Authors

  • Salahuddin Pak Emirates Military Hospital, Rawalpindi-Pakistan
  • Malik Nadeem Azam Nephrology Department, PEMH, Rawalpindi-Pakistan
  • Khalid Mehmood Raja Nephrology Department, PEMH, Rawalpindi-Pakistan
  • Abdur Rehman Arshad Nephrology Department, CMH, Peshawar
  • Faryal Riaz Khan Gastroentrology Department, PEMH, Rawalpindi-Pakistan
  • Abdul Wahab Mir Department of Nephrology, PEMH, Rawalppindi-Pakistan
  • Taleha Tahir Nephrology Department, PEMH, Rawalpindi-Pakistan
  • Batool Butt Nephrology Department, Fauji Foundation Hospital, Rawalpindi-Pakistan
  • Wahaj Nephrology Department, Abbottabad Internation Medical College, Abbottabad-Pakistan
  • Anum Khan Department of Medicine, PEMH, Rawalpindi-Pakistan

Abstract

Background:  Multiple   options   have   been   tried   to   counter   the proteinuria   secondary   to   renal   diseases. Clinicians and researchers are trying to find the best option for this purpose. Objective: To compare efficacy of Losartan and Diltiazem in management of proteinuria in non-diabetic renal diseases at a tertiary care hospital of Pakistan. It was a Quasi-experimental study, conducted at the Department of nephrology Pak Emirates Military Hospital Rawalpindi. Five months, November 2020 to March 2021. Methods:  A total of 122 patients of non-diabetic renal diseases with significant proteinuria were included in the study. They were randomly divided into two groups via lottery method. Group I received losartan while group II received Diltiazem in standard dose for three months. After three months they underwent 24 hours’ urinary protein levels and divided into complete, partial and non-responders to treatment. Age, gender, duration of illness and type of antiproteinuric treatment was correlated with response to treatment among the study population. Results:  Out of 122 patients, 80 (65.6%) were males while 42 (34.4%) were females. Membranous nephropathy 20 (16.4%) was the commonest non-diabetic renal disease seen in our study participants. Thirty (24.5%) had complete remission after three months of treatment, 60 (49.2%) had partial response while 32 (26.3%) had no response to treatment. Chi-square test revealed that use of losartan had statistically significant relationship (p-value<0.001) with good response among the study participants.  CONCLUSION: Membranous nephropathy leading to proteinuria was the commonest non-diabetic renal disease encountered in our setup. Around 2/3rd of our patients showed either complete or partial response to treatment and Losartan was superior to Diltiazem in achieving response in our study participants.

Author Biography

Salahuddin, Pak Emirates Military Hospital, Rawalpindi-Pakistan

Nephrology Department

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Published

2021-07-05