ASSOCIATION OF BONE MINERAL PROFILE WITH RESTLESS LEG SYNDROME IN PATIENTS WITH END STAGE RENAL DISEASE.
DOI:
https://doi.org/10.55519/JAMC-03-S1-9745Keywords:
restless leg syndrome, Bone Mineral profile, Hemodialysis, End stage renal disease.Abstract
Background: Restless leg syndrome (RLS) is one of the problem hemodialysis patients may encounter. This study was done to find out the association of restless legs syndrome (RLS) in end stage renal disease patients with serum calcium, phosphorus and parathyroid hormone levels. Methods: This cross-sectional observational study was done at The Kidney Centre, postgraduate Training Institute Karachi, Pakistan from Jan to June 2020. One hundred and twelve patients on three per week hemodialysis for more than three months at our hemodialysis centre were face to face interviewed as per International Restless Legs Syndrome Study Group criteria (IRLSSG) for the presence of RLS symptoms. Their demographic data and laboratory values were recorded from history chart and computer records. The bone mineral profile in this study includes serum calcium (corrected for albumin), serum phosphate levels and serum intact Parathyroid hormone (iPTH) levels. Statistical analyses were done by using SPSS-21. Results: In our study, 38.4% patients had RLS. Serum phosphorus levels were significantly higher in patients with RLS as compared to those who didn’t have RLS. No significant association of serum calcium and Parathyroid hormone (PTH) levels with RLS was found. Conclusion: There is a high prevalence of RLS in ESRD patients as compared to general population. Serum phosphorus levels need to be observed and corrected along with maintenance of calcium and PTH levels to improve symptoms of RLS in these patients.References
Baheti DK. Restless Leg Syndrome: Causes and Pain Management. Symptom Oriented Pain Manag 2017;31:395.
Allen RP, Picchietti D, Hening WA, Trenkwalder C, Walters AS, Montplaisi J. Restless Legs Syndrome Diagnosis and Epidemiology workshop at the National Institutes of Health; International Restless Legs Syndrome Study Group. Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. Sleep Med 2003;4(2):101–19.
Hasheminasab Zaware R, Mahmoodi Meymand MH, Rezaeian M, Mohammadi Kamalabadi N, Mostafavi SA, Abdolkarimi Dawarani MA, et al. Insomnia and Restless Leg Syndrome in Patients Undergoing Chronic Hemodialysis in Rafsanjan Ali Ibn Abitaleb Hospital. Nephrourol Mon 2016;8(1):e29527.
Scherer JS, Combs SA, Brennan F. Sleep Disorders, Restless Legs Syndrome, and Uremic Pruritus: Diagnosis and Treatment of Common Symptoms in Dialysis Patients. Am J Kidney Dis 2017;69(1):117–28.
Gurung MA, Dangwal MA, Saini MG, Tiwari MS, Rana MS, Praveen MS. To assess the prevalence & knowledge regarding restless leg syndrome during pregnancy among pregnant women. Int J Sci Res 2020;9(1):54–6.
Högl B, Stefani A. Restless legs syndrome and periodic leg movements in patients with movement disorders: Specific considerations. Mov Disord 2017;32(5):669–81.
Saraji NZ, Hami M, Boostani R, Mojahedi MJ. Restless leg syndrome in chronic hemodialysis patients in Mashhad hemodialysis centers. J Renal Inj Prev 2017;6(2):137–41.
Yildiz D, Kahvecioglu S, Buyukkoyuncu N, Kilic AK, Yildiz A, Gul CB, et al. Restless-legs syndrome and insomnia in hemodialysis patients. Ren Fail 2016;38(2):194–7.
Lin XW, Zhang JF, Qiu MY, Ni LY, Yu HL, Kuo SH, et al. Restless legs syndrome in end stage renal disease patients undergoing hemodialysis. BMC Neurol 2019;19(1):47.
Kraus MA, Fluck RJ, Weinhandl ED, Kansal S, Copland M, Komenda P, et al. Intensive Hemodialysis and Health-Related Quality of Life. Am J Kidney Dis 2016;68(5S1):S33–42.
Sakhuja V, Kohli HS. End-stage renal disease in India and Pakistan: incidence, causes, and management. Ethn Dis 2006;16(2 Suppl 2):S2–23.
Pitt SC, Sippel RS, Chen H. Secondary and tertiary hyperparathyroidism, state of the art surgical management. Surg Clin North Am 2009;89(5):1227–39.
Oliveira RB, Cancela AL, Graciolli FG, Dos Reis LM, Draibe SA, Cuppari L, et al. Early control of PTH and FGF23 in normophosphatemic CKD patients: a new target in CKD-MBD therapy. Clin J Am Soc Nephrol 2010;5(2):286–91.
Jha V, Garcia-Garcia G, Iseki K, Li Z, Naicker S, Plattner B, et al. Chronic kidney disease: global dimension and perspectives. Lancet 2013;382(9888):260–72.
Abubakar II, Tillmann T, Banerjee A. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the global burden of disease study 2013. Lancet 2015;385(9963):117–71.
Hasan M, Sutradhar I, Gupta RD, Sarker M. Prevalence of chronic kidney disease in South Asia: a systematic review. BMC Nephrol 2018;19(1):291.
Singh S, Upadhyay-Dhungel K, Aryal G. Value of Calcium and Phosphorous in chronic kidney disease patients under hemodialysis: A retrospective study. J Pathol Nepal 2012;2(4):293–6.
Jamal Y, Siddiqui UA, Raza A, Abbas K. Restless legs syndrome in end stage renal disease patients undergoing maintenance hemodialysis. Pak Armed Forces Med J 2014;64(4):600–4.
Haider I, Anees M, Shahid SAH. Restless legs syndrome in end stage renal disease patients on haemodialysis. Pak J Med Sci 2014;30(6):1209–12.
Ul Abideen Z, Mahmud SN, Mushtaq F, Farooq MU, Farooq Qasim Y, Hamid Z, et al. Association of hemodialysis inadequacy and duration with restless legs syndrome: A cross-sectional study. Cureus 2018;10(5):e2570.
Mao S, Shen H, Huang S, Zhang A. Restless legs syndrome in dialysis patients: a meta-analysis. Sleep Med 2014;15(12):1532–8.
Giannaki CD, Hadjigeorgiou GM, Karatzaferi C, Pantzaris MC, Stefanidis I, Sakkas GK. Epidemiology, impact, and treatment options of restless legs syndrome in end-stage renal disease patients: an evidence-based review. Kidney Int 2014;85(6):1275–82.
Mansourian M, Rafie N, Khorvash F, Hadi A, Arab A. Are serum vitamin D, calcium and phosphorous associated with restless leg syndrome? A systematic review and meta-analysis. Sleep Med 2020;75:326–34.
Neves PD, Graciolli FG, Oliveira IB, Bridi RA, Moysés RM, Elias RM. Effect of mineral and bone metabolism on restless legs syndrome in hemodialysis patients. J Clin Sleep Med 2017;13(1):89–94.
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