CLINICAL STAGE OF ORAL CANCER PATIENTS AT THE TIME OF INITIAL DIAGNOSIS

Authors

  • Irfan Shah
  • Omer Sefvan
  • Uzair Luqman
  • Waseem Ibrahim
  • Sana Mehmood
  • Wajiha Alamgir

Abstract

Background: Squamous cell carcinoma is the most common oral cancer. Early diagnosis ensuresbetter prognosis. Late diagnosis is however common around the world and contributes to the highmorbidity and mortality related to oral cancer. The objective of this study was to determine theclinical stage of oral cancer patients at the time of diagnosis. Methods: This retrospective study wascarried out on 334 oral cancer patients who presented to the outdoor departments of Armed ForcesInstitute of Dentistry, and Armed Forces Institute of Pathology, Rawalpindi from July 2008 toDecember 2009. The records that were reviewed included history and clinical examination findings,OPG and CT scans of the head and neck region, chest X-rays, abdominal ultrasounds and liverfunction tests. Size of the primary tumour, the size, number and laterality of the involved cervicallymph nodes and the presence/absence of distant metastases were documented and statisticallyanalysed using SPSS-17. Results: Out of the 334 patients, 203 (60.8%) were males and 131(39.2%) females. The age range was from 21 to 88 years. Buccal mucosa was the most commonlyinvolved site (32 %). The primary tumour was 4 Cm or more in size, (T3/T4) 71.25% of the cases.Cervical lymph nodes were involved in 211 patients (63.2%) and distant metastases were present in39 patients (11.7%). Overall, clinical stage IV was the most common (57.18%) followed by stage III(24.55%), stage II (13.77%) and stage I (4.49%). Conclusion: Oral cancers are diagnosed late (StageIII and IV) in Pakistan and need immediate public and professional attention.Keywords: Oral Cancer, Clinical Staging, TNM Staging

References

Chi AC. Epithelial Pathology In: Neville BW, Damm DD, Allen

CM, Bouquot JE. Oral & Maxillofacial Pathology. 3rd ed.

Philadelphia: Saunders; 2009.p. 362–452.

Wahid A, Ahmad S, Sajjad M. Pattern of Carcinoma of the Oral

Cavity Reporting at dental Department of Ayub Medical College.

J Ayub Med Coll 2005;17(1):65–6.

Sargern K, Murtomaa H, Safavi SMR, Vehkalahti MM, Teronen

O. Survival after diagnosis of cancer of the oral cavity. Br J Oral

Maxillofac Surg 2008;46:187–91.

Massano J, Regateiro FS, Janua´rio G, Janua´rio A, Oral

squamous cell carcinoma: Review of prognostic and predictive

factors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod

;102:67–76.

Bagan J, Sarrion G, Jimenez Y. Oral cancer: clinical features.

Oral Oncol 2010;46:414–7.

Sciubba JJ. Oral cancer and its detection - History-taking and the

diagnostic phase of management J Am Dent Assoc

;132(supplement):12S–18S.

Scully C, Bagan JV, Hopper C, Epstein JB. Oral cancer: Current

and future diagnostic techniques Am J Dent 2008;21:199–209.

Warnakulasuriya S. Global epidemiology of oral and

oropharyngeal cancer. Oral Oncol 2009;45:309–16.

McLeod NM, Saeed NR, Ali EA. Oral cancer: Delays in referral

and diagnosis persist. Br Dent J 2005;198:681–4.

Brandizzi D, Gandolfo M, Velazco ML, Cabrini RL, Lanfranchi

HE. Clinical features and evolution of oral cancer: a study of 274

cases in Buenos Airs, Argentina. Med Oral Patol Oral Cir Buccal

;13:E544–8.

Denoix PF. Bull Inst Nat Hyg (Paris) 1944;1:52–82.

Schroeff MP, Baatenburg de Jong RJ. Staging and prognosis in

head and neck cancer. Oral Oncol 2009;45:356–60.

Araújo-Júnior RF, Barboza CA, Clebis NK, Moura SA, Costa

AL. Prognostic significance of the anatomical location and TNM

clinical classification in oral squamous cell carcinoma. Med Oral

Patol Oral Cir Bucal 2008;13:E344–7.

Macfarlane GJ, Boyle P, Scully C. Oral cancer in Scotland:

changing incidence and mortality. BMJ 1992;305:1121–3.

Chen J, Eisenberg E, Krutchkoff DJ, Katz RV. Changing trends

in oral cancer in the United States, 1935–1985: A Connecticut

study J Oral Maxillofac Surg 1991;49:1152–8.

Sherin N, Simi T, Shameena PM, Sudha S. Changing trends in

oral cancer. Indian J Cancer 2008;45:93–6.

Lam L, Logan RM, Luke C. Epidemiological analysis of tongue

cancer in South Australia for the 24-year period, 1977–2001.

Aust Dent J 2006;51:(1):16–2.

Published

2010-09-01

Issue

Vol. 22 No. 3 (2010): JOURNAL OF AYUB MEDICAL COLLEGE, ABBOTTABAD

Section

ORIGINAL ARTICLE

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