HYPOCELLULAR MYELODYSPLASTIC SYNDROME PRESENTING AS MEGALOBLASTIC ANEMIA
Abstract
Myelodysplastic Syndromes (MDS) are a heterogenous group of clonal stem cell disorders which generally occur in older adults but may also affect children. The ineffective hematopoiesis which causes bone marrow failure is accompanied by peripheral blood cytopenia1. MDS are classified into 5 different morphologic categories according to French-American-British (FAB) classification1,2,3. Hypocellular Myelodysplasia is a less common variant of MDS, characterized by hypocellular marrow in which a small proportion of blasts may be seen usually with occasional blasts in the peripheral blood2. We have encountered a distinct young patient of hypocellular MDS presented as megaloblastic anemia and pancytopenia.References
Schmitt-Graeff A, Mattern D, Kohler H, Hezel J, Lubbert M. Myelodysplastic syndromes (MDS). Aspects of haematopathologic diagnosis. Pathologe 2000;21(1):1-15.
Gordon-Smith EC. Aplastic anaemia. In: Weatherall DJ, Ledinghim JG, Warrell DA. Oxford textbook of Medicine. 3rd ed. Oxford: Oxford University Press;1996:3447.
Malaspina CH, O’Reilly JR. Myelodysplastic syndromes. In: Fauci AS, Braunwald E, Wilson DJ, Martin BJ, Kasper, Hauser SL, eds. Harrison’s Priniciples of Internal Medicine. 14th ed. New York: McGraw-Hill; 1998:678.
Drabick JJ, Davis BJ, Byrd JC. Concurrent pernicious anaemia and myelodysplastic syndrome. Ann Hematol 2001;80(4):243-5.
Lorand-Metze I, Meira DG, Lima CS, Vassallo J, Metze K. The differential diagnosis between aplastic anaemia and hypocellular myelodysplasia in patients with pancytopenia. Haematologica 1999;84(6):564-5.
Barrett J, Saunthararajah Y, Molldrem J. Myelodysplastic syndrome and aplastic anaemia: distinct entities or diseases linked by a common pathophysiology? Semin Hematol 2000;37(1):15-29.
Elghetany MT, Hudnall SD, Gardner FH. Peripheral blood picture in primary hypocellular refractory anaemia and idiopathic acquired aplastic anaemia: an additional tool for differential diagnosis. Haematologica 1997;82(1):21-4.
Varma N, Varma S, Marwaha N, Garewal G. Aplastic anaemia versus hypocellular myelodysplastic syndrome. Indian J Cancer 1995;32(3):110-5.
Toyama K, Ohyashiki K, Yoshida Y, Abe T, Asano S, Hirai H, et al. Clinical and cytogenetic findings of myelodysplastic syndromes showing hypocellular bone marrow or minimal dysplasia, in comparison with typical myelodysplastic syndromes. Int J Hematol 1993;58(1-2):53-61.
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