FREQUENCY OF ALBUMINURIA IN DIABETIC PATIENTS PRESENTING WITH MACROVASCULAR COMPLICATIONS

Authors

  • Muhammad Sohail
  • Fozia Fatima
  • Sadia Fatima
  • Shahbaz Ali Khan
  • Syed Abbas Anwar
  • Muhammad Adeel Alam
  • Munir Ahmad Abbasi

Abstract

Background: Diabetes mellitus is major cause of morbidity and premature mortality fromits long term complications such as cardiovascular disease, blindness, renal failure, amputation and stroke. The study was conducted to determine the frequency of albuminuria in diabetic patients presenting with macro-vascular complications like myocardial infarction (MI) and stroke. Methods: This descriptive study was conducted at Ayub Medical College, Abbottabad from December 2010 to May 2011. Total 88 diabetic patients admitted with macro-vascular disease were included in this study. The patients were subjected to two urine specimen’s examination, one for routine examination for infection and dipstick analysis for albuminuria. Second was tested for albumin was tested in the urine. Results: Out of 88 patients with a mean 47.12±7.58 years, 39 (44.32%) were female while 49 (55.68%) were male. Overall albuminuria was detected in the urine of 81 out of total 88 patients (92%) when tested by heating method whereas it was detected in 41 (46.6%) cases by the dipstick method. Conclusion: Frequency of albuminuria is much higher in diabetic population with macro-vascular complications; hence albumin in the urine of diabetic patient can be regarded as an indicator for impending macro-vascular complications of diabetes.Keywords: Diabetes mellitus, macro-vascular disease, albuminuria, complications, CVA

References

Wild S, Roglic G, Green A, Sicree R, King H. Global Prevalance of Diabetes: Estimates for the year 2000 and projection for 2030. Diabetes Care 2004; 27:1047–53.

Cali AMG, Caprio S. Prediabetes and type 2 diabetes in youth: an emerging epidemic disease? Curr Opin Endocrinol Diabetes Obesity 2008;15:123–7

Ramachandran A, Snehalatha C. Current scenario of diabetes in India. J Diabetes 2009;1:18–28

Iqbal F, Naz R. Pattern of diabetes mellitus in Pakistan; An overview of the problem. Pak J Med Res 2005;44:59–64.

Khowaja LA, Khuwaja AK, Cosgrove P. Cost of diabetes care in out-patient clinics of Karachi, Pakistan. BMC Health Serv Res 2007;7:189.

Goff DC Jr, Gerstein HC, Ginsberg HN, Cushman WC, Margolis KL, Byington RP, et al. Prevention of cardiovascular disease in persons with type 2 diabetes mellitus: current knowledge and rationale for the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial. Am J Cardiol 2007;99(12A):4i–20i.

Stevan RJ, Kothari V, Adler Al. Stratton IM; United Kingdom Prospective Diabetes Study (UKPDS) Group. The UKPDS risk engine: a model for the risk of coronary heart disease in Type II diabetes (UKDPS 56). Clin Sci 2001;101:671–9.

Franklin K, Goldberg RJ, Spencer F, Klein W, Budaj A, Brieger D, et al. Implications of diabetes in patients with coronary syndromes. The global registry of acute coronary events. Arch Intern Med 2004;164:1457–63.

Sheikh BA, Sheikh WM, Solangi GA, Sangi SA, Abro HA, Sheikh AM, et al. Diabetes mellitus (Diagnosed and undiagnosed) in acute myocardial infarction. Med Channel 2006;12(2):36–9.

Donahoe SM, Stewart GC, McCabe CH, Mohanavelu S, Murphy SA, Cannon CP, et al. Diabetes and mortality following acute coronary syndromes. JAMA 2007;298:765–75.

Lopes-Virella MF, Carter RE, Gilbert GE, Klein RL, Jaffa M, Jenkins AJ, et al. Risk factors related to inflammation and endothelial dysfunction in the DCCT/EDIC cohort and their relationship with nephropathy and macrovascular complications. Diabetes Care 2008;31:2006–12.

Satchell SC, Tooke JE. What is the mechanism of microalbuminuria in diabetes: a role for the glomerular endothelium? Diabetologia 2008;51:714–25.

Meisinger C, Heier M, Landgraf R, Happich M, Wichmann HE, Piehlmeier W. Albuminuria, cardiovascular risk factors and disease management in subjects with type 2 diabetes: a cross sectional study. BMC Health Serv Res 2008;8:226.

Chandy A, Pawar B, John M, Isaac R. Association between diabetic nephropathy and other diabetic microvascular and macrovascular complications. Saudi J Kidney Dis Transpl 2008;19:924–8.

Begley D, Cullen S, Davies C, Dhinoja M, Earley M, Graham J, et al. Drugs for heart: Ranozoline. In: Ramrakha PS, Hill J. editors. Oxford handbook of cardiology. New York: Oxford university press Inc; 2006.p. 140–1

Thomas GN, Lin JW, Lam WW, Tomlinson B, Yeung V, Chan JC, et al. Albuminuria is a marker of increasing intracranial and extracranial vascular involvement in Type 2 diabetic Chinese patients. Diabetologia 2004;47:1528–34.

Rosenson RS, Fioretto P, Dodson PM. Does microvascular disease predict macrovascular events in type 2 diabetes? Atherosclerosis 2011;218:13–8.

Groop PH, Thomas MC, Moran JL, Waden J, Thorn LM, Makinen VP, et al. The presence and severity of chronic kidney disease predicts all-cause mortality in type 1 diabetes. Diabetes. 2009;58:1651–8.

Dinneen SF1, Gerstein HC. The association of microalbuminuria and mortality in non-insulin dependent diabetes mellitus. Arch Intern Med 1997;157:1413–18.

Lee M, Saver JL, Chang KH, Ovbiagele B. Level of albuminuria and risk of stroke: systematic review and meta-analysis. Cerebrovasc Dis 2010;30:464–9.

Published

2014-06-01

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