PATTERN OF PRESENTATION AMONG ADULTS HOSPITALIZED WITH DENGUE DISEASE

Authors

  • Abdul Rauf Assistant professor Medicine Ayub Medical, College Abbotabad
  • Nasir Hussain Shah Kazmi Associate professor Medicine Ayub Medical, College Abbotabad
  • Haider Zaman Senior Registrar Medicine Ayub Medical, College Abbotabad
  • Saima Gillani
  • Tariq Shah
  • Faizan Malik
  • Shoaib Ismaeel

Abstract

AbstractBackground: Dengue is a mosquito born viral infection that has rapidly spread in the world particularly in Southeast Asia. The aim of this hospital based study was to see the demographic, clinical and laboratory characteristics in adults with dengue infection in Hazara region of Northern Pakistan.Method:  This is a prospective observational study. Clinical, laboratory and demographic information were collected from adult patients with suspected dengue infection (N= 100) and then managed in one of medical units of tertiary care hospital in Abbottabad from August to October 2015.Results:Total number of patients were 100, 78 were male and 22 were female.  49 patients were in age group from 21 to 40 years. Most patients were from Mansehra district (69), followed by Haripur (11), Abbottabad (11), Batgram (06) and Kohistan (03). Common clinical features were fever (100%), body aches (95%), headache (94%), chills (87%), and anorexia (86%), hemorrhagic tendencies (12%), rash (05%), and sore throat (03%). Thrombocytopenia was observed in 98%, leucopenia in 25%, high Aminotransferases (ALT) in 67%, Ns1 antigen positive 66%, negative 18% and unknown 16%. IgM Antibodies against Dengue Virus was positive 67%, negative 19% and were unknown in 14%, IgG antibodies positive in 54%, negative 32% and were unknown in 14%. Conclusion:We concluded in our study that presentation of dengue infection is same as in other Southeast Asian countries; however, the disease is more prevalent in cities located on plain than hilly areas.Keywords: Dengue, Ades Aegypti, Fever, Pattern, Clinical features, Laborator Characteristics, Hazara Region. Background: Dengue is a mosquito born viral infection that has rapidly spread in the world particularly in Southeast Asia. The aim of this hospital based study was to see the demographic, clinical and laboratory characteristics in adults with dengue infection in Hazara region of Northern Pakistan. Methods: This is a descriptive study. Clinical, laboratory and demographic information were collected from adult patients with suspected dengue infection (n=100) and then managed in one of medical units of tertiary care hospital in Abbottabad from August to October 2015. Results: Total number of patients was 100, 78 were male and 22 were female. 49 patients were in age group from 21 to 40 years. Most patients were from Mansehra district (69), followed by Haripur (11), Abbottabad (11), Battagram (06) and Kohistan (03). Common clinical features were fever (100%), body aches (95%), headache (94%), chills (87%), and anorexia (86%), haemorrhagic tendencies (12%), rash (05%), and sore throat (03%). Thrombocytopenia was observed in 98%, leucopoenia in 25%, high Aminotransferases (ALT) in 67%, Ns1 antigen positive 66%, negative 18% and unknown 16%. IgM Antibodies against Dengue Virus was positive 67%, negative 19% and were unknown in 14%, IgG antibodies positive in 54%, negative 32% and were unknown in 14%. Conclusion: We concluded in our study that presentation of dengue infection is same as in other Southeast Asian countries; however, the disease is more prevalent in cities located on plain than hilly areas.Keywords: Dengue; Ades Aegypti; Fever; Pattern; Clinical features; Laboratory; Characteristics; Hazara Region

Author Biography

Abdul Rauf, Assistant professor Medicine Ayub Medical, College Abbotabad

Assistant professor department of Medicine

References

Brady OJ, Gething PW, Bhatt S, Messina JP, Brownstein JS, Hoen AG, et al. Refining the global spatial limits of dengue virus transmission by evidence-based consensus. PLoS Negl Trop Dis 2012;6(8):e1760.

Paul RE, Patel AY, Mirza S, Fisher-Hoch SP, Luby SP. Expansion of epidemic dengue infection to Pakistan. Int J Infect Dis 1998;2(4):197–201.

Khan E, Siddiqui J, Shakoor S, Mehraj V, Jamil B, Hasan R. Dengue outbreak in Karachi, Pakistan, 2006: experience at a tirtiary care centre. Trans R Soc Trop Med Hyg 2007:101(11):1114–9.

Hakim ST, Tayyab SMH, Nadeem SG. An experience with dengue in Pakistan: An expanding problem. Ibnosina J Med Biomed Sci 2011;3(1):3–8.

Shakoor MT, Ayua S, Ayub Z. Dengue fever: Pakistan worst nightmare. WHO South-East Asia J Public Health 2012:1(3):229–31.

Khan E, Kisat M, Khan N, Nasir A, Ayub S, Hasan R. Demographic and clinical features of dengue fever in Pakistan from 2003-2007: a retrospective cross-sectional study. PLoS One 2010:5(9):e12505.

Cordeiro MT, Schatzmayr HG, Nogueira RM, Oliveira VF, Melo WT, Carvalho EF. Dengue and dengue hemorrhagic fever in the state of Pernambuco, 1995-2006. Rev Soc Bras Med Trop 2007:40(6):605–11.

Dhobale RV, Gore AD, Waghachavare VB, Kumbhar SG, Kadam YR, Dhumale GB. Clinical and Laboratory Characteristics of Pediatric Dengue Fever Patients in a Tertiary Care Hospital. Natl J Community Med 2016;7(1):21–4.

Schexeider K, Reedy E. Thrombocytopenia in dengue fever. Curr Hematol Rep 2005:4(2)145–8.

Hottz E, Tolley ND, Zimmerman GA, Weyrich AS, Bozza FA. Platelets in dengue infection. Drug Discov Today Dis Mech 2011;8(1):e33–8.

Kularatne SA, Gwarammana IB, Kumarasiri PR. Epidemiology, clinical features, laboratory investigations and early in adults: a descriptive study in Sri Lanka. Southeast Asian J Trop Med Public Health 2005:36(3):686–92.

Tricou V, Vu HT, Quynh NV, Nguyen CV, Tran HT, Farar J, et al. Comparison of two dengue NS1 rapid tests for sensitivity, specificity, and relationship to viremia and responses. BMC Infect Dis 2010;10:142.

Kumarasamy V, Chua SK, Hassan Z, Wahab AH, Chem YK, Mohmad M, et al: Evaluating the sensitivity of a commercial dengue NS1 antigen-capture ELISA for early diagnosis of acute dengue infection. Singapore Med J 2007:48(7):669–73.

Schilling S, Ludolf D, Van An L, Schmitz H. Laboratory diagnosis of primary and secondary dengue infection. J Clin Virol 2004:31(3):179–84.

Published

2017-06-25

Issue

Vol. 29 No. 3 (2017): JOURNAL OF AYUB MEDICAL COLLEGE, ABBOTTABAD

Section

ORIGINAL ARTICLE

License

Journal of Ayub Medical College, Abbottabad is an OPEN ACCESS JOURNAL which means that all content is FREELY available without charge to all users whether registered with the journal or not. The work published by J Ayub Med Coll Abbottabad is licensed and distributed under the creative commons License  CC BY ND Attribution-NoDerivs. Material printed in this journal is OPEN to access, and are FREE for use in academic and research work with proper citation. J Ayub Med Coll Abbottabad accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing in J Ayub Med Coll Abbottabad. The Editorial Board of J Ayub Med Coll Abbottabad makes every effort to ensure the accuracy and authenticity of material printed in J Ayub Med Coll Abbottabad. However, conclusions and statements expressed are views of the authors and do not reflect the opinion/policy of J Ayub Med Coll Abbottabad or the Editorial Board.

USERS are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.

AUTHORS retain the rights of free downloading/unlimited e-print of full text and sharing/disseminating the article without any restriction, by any means including twitter, scholarly collaboration networks such as ResearchGate, Academia.eu, and social media sites such as Twitter, LinkedIn, Google Scholar and any other professional or academic networking site.

Most read articles by the same author(s)

<< < 1 2