ASSOCIATION OF LEPTIN WITH TYPE 2 DIABETES IN NON-OBESE SUBJECTS
AbstractBackground: South Asians have a high tendency to develop type 2 diabetes even at low BMI. Weevaluated serum leptin levels in a group of non-obese type 2 diabetics. Methods: An observational studyconducted on 90 subjects, 55 with Type 2 diabetes mellitus, and 35 normal controls (non-diabetics).BMI, waist circumference, serum leptin, and serum glucose were measured. The correlation betweenthese variables was studied by multiple regression analysis. Results: Serum leptin levels were positivelycorrelated with BMI in obese (r=0.976) and non-obese diabetics (r=0.956). Serum leptin was relatedwith diabetes (r= -0.153, p=0.001). Serum leptin was highly correlated with waist circumference inobese than non-obese diabetics, (r=0.753). Mean serum leptin level was 21.4 ηg/ml in non-obesediabetics and 34.9 ηg/ml in diabetic group. It is even lower than the non-obese, non-diabetics (23.3ηg/ml). Multivariate linear regression analysis between leptin and age, weight, BMI, waist circumferencein patients shows only a strong association with BMI in diabetics (p=0.0001), while in non-diabetic itwas not significant (p=0.07). Serum leptin was high in diabetics taking oral hypoglycaemic (37.8±19.1ηg/ml), while it was low in diabetics taking insulin injections (29.3±24.2 ηg/ml). Conclusion: Lowleptin levels are associated with type 2 diabetes mellitus independent of changes in BMI.Keywords: Leptin, BMI, waist circumference, type-2 diabetes mellitus, serum glucose.
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