EFFECTS OF CIPROFLOXACIN AND ZINC CHLORIDE IN ADULT ALBINO RAT AND PRE-NATAL CONCEPTUS
AbstractBackground: Administration of quinolone therapy is controversial during growing age asstated by earlier authors. The flouroquinolones are currently not indicated for youngchildren because of arthropathy and adverse effect as new born shown by studies. Howeverthe effects of ciprofloxacin and ZnCl2 on prenatal conceptus have remained undocumented.The present study was designed to compare the effects on conceptus after maternalingestion of ciprofloxacin and ZnCl2 using Wastar albino rats. Methods: Ciprofloxacin andZnCl2 was administrated to pregnant female albino rats. Ciprofloxacin with a dose of 20mg/Kg bodyweight and ZnCl2 120 µg/100 gm bodyweight two times therapeutic dose for10 days (from day 8–18 of pregnancy). Each animal was weighted on day 1, day 8 and day18 of pregnancy. Abortion resulted on day 18th of pregnancy. Each group of pregnantanimals were sacrificed on day 18 of gestation by over dose of either anaesthesia, abdomenopened, uterus and both cornua containing conceptus identified, removed, there weightrecorded, crown rump length was measured and was compared with similar value of controlanimals. The results were statistically analysed to find out the significance. Results: Theciprofloxacin induces a mordanting effect as obviated by increased basophilia. Our studyreveals that ciprofloxacin administered in maternal, decreased maternal body weight to38.4±0.9 gm. However simultaneous ZnCl2 maintained the body weight to 41.4±0.7 gm,while ZnCl2 increased the body weight to 46.5±2.25 gm. The body weight and CrownRump length (CR Length) in conceptus decreased by 4.52±0.10 gm and 3.06±0.09 Cmrespectively. That ciprofloxacin and ZnCl2 administration maintained the body weight andCR length by 5.46±0.09 gm and 3.79±0.13 Cm respectively. That ZnCl2 administrationincreased the body weight and CR length by 6.71±0.05 gm and 4.15±0.08 Cm respectively.Conclusion: Prenatal administration of Ciprofloxacin caused reduction in growth rate andCR length, and ZnCl2 maintained body weight and CR length and growth of the ratconceptus.Keywords: Ciprofloxacin, ZnCl2, body weight, crown rump length, conceptus
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