OBESITY, FAT TOPOGRAPHY AND RISK OF CARCINOMA BREAST

Authors

  • Ayesha Khan Ayub teaching hospital
  • Kashif Rafique Ayub teaching hospital
  • Umer Farooq Ayub teaching hospital
  • Khalid Khan Ayub teaching hospital

Abstract

Background: Carcinoma breast is most common cancer and the leading cause of cancer related deaths in women, with a multifactorial aetiology. This case control study was aimed at studying the possible link of body fat with the pathogenesis of carcinoma breast. Methods: A case control study extending over a period of two years (2015–2016) was conducted in which the body size and shape of 56 carcinoma breast cases was studied against 168 controls who had no breast disease. Results: Fifty-six women suffering from carcinoma breast had a higher BMI and fat distributed in the abdominal area A high BMI was found to be protective in pre-menopausal women (OR= 0.14 by; 95% CI: 0.02–0.77) while it was a risk factor in post-menopausal women (OR=2.39 by; 95% CI: 1.02–5.55). Waist-to-hip ratio (WHR) of ≥0.9 was associated with an increased risk of carcinoma breast compared to WHR ≤0.8 (OR=3.857 by; 95% CI: 0.875–17.05). Conclusion: the results show there is an increased risk of carcinoma breast in women having more fat cantered around the abdomen.Keywords: postmenopausal; weight gain; fat distribution; fat topography; carcinoma breast; body mass index; body shape; obesity; central obesity

Author Biographies

Ayesha Khan, Ayub teaching hospital

General surgery resident, surgical A unit, Ayub teaching hospital.

Kashif Rafique, Ayub teaching hospital

senior registrar, surgical A unit, Ayub teaching hospital

Umer Farooq, Ayub teaching hospital

Associate professor community medicine, deputy dean Ayub teaching hospital

Khalid Khan, Ayub teaching hospital

professor surgery, head of surgery and allied, Ayub teaching hospital

References

Memon ZA1, Qurrat-ul-Ain, Khan R, Raza N, Noor T. Clinical Presentation and Frequency of Risk Factors in Patients with Breast Carcinoma in Pakistan. Asian Pac J Cancer Prev 2015;16(17):7467–72.

Nemesure B, Wu SY, Hennis A, Leske MC. Body size and breast cancer in a black population--the Barbados National Cancer Study. Cancer Causes Control 2009;20(3):387–94.

Montazeri A, Sadighi J, Farzadi F, Mafroon F, Vahdaninia M, Ansari M, et al. Weight, height, body mass index and risk of breast cancer in postmenopausal women: a case-control study. BMC Cancer 2008;8(1):278.

Scutt D, Manning JT, Whitehouse GH, Leinster SJ, Massey CP. The relationship between breast asymmetry, breast size and the occurrence of breast cancer. Br J Radiol 1997;70(838):1017–21.

Morimoto LM, White E, Chen Z, Chlebowski RT, Hays J, Kuller L, et al. Obesity, body size, and risk of postmenopausal breast cancer: the Women's Health Initiative (United States). Cancer Causes Control 2002;13(8):741–51.

Barnes-Josiah D, Potter JD, Sellers TA, Himes JH. Early body size and subsequent weight gain as predictors of breast cancer incidence. Cancer Causes Control 1995;6(2):112–8.

Koch AD, Nicolai JP, de Vries J. Breast cancer and the role of breast size as a contributory factor.

Breast 2004;13(4):272–5.

Tavani A, Pregnolato A, La Vecchia C, Negri E, Favero A, Franceschi S. Breast size and breast cancer risk. Eur J Cancer Prev 1996;5(5):337–42.

Agurs-Collins T, Adams-Campbell LL, Kim KS, Cullen KJ. Insulin-like growth factor-1 and breast cancer risk in postmenopausal African-American women. Cancer Detect Prev 2000;24(3):199–206.

Mathew A, Gajalakshmi V, Rajan B, Kanimozhi V, Brennan P, Mathew BS, et al. Anthropometric factors and breast cancer risk among urban and rural women in South India: a multicentric case-control study. Br J Cancer 2008;99(1):207–13.

Cleary MP, Grossmann ME. Minireview: Obesity and Breast Cancer: The estrogen connection. Endocrinology 2009;150(6):2537–42.

Hankinson SE, Willett WC, Manson JE, Hunter DJ, Colditz GA, Stampfer MJ, et al. Alcohol, Height, and Adiposity in Relation to Estrogen and Prolactin Levels in Postmenopausal Women. J Natl Cancer Inst 1995;87(17):1297–302.

Van Landeghem AA, Poortman J, Nabuurs M, Thijssen JH. Endogenous concentration and subcellular distribution of androgens in normal and malignant human breast tissue. Cancer Res 1985;45(6):2907–12.

Tavani A, Braga C, La Vecchia C, Parazzini F, Talamini R, Franceschi S. Height and breast cancer risk. Eur J Cancer 1998;34(4):543–7.

Lorincz AM, Sukumar S. Molecular links between obesity and breast cancer. Endocr Relat Cancer 2006;13(2):279–92.

Sonnenschein E, Toniolo P, Terry MB, Bruuing PF, Kato I, Koenig KL, et al. Body fat distribution and obesity in pre- and postmenopausal breast cancer. Int J Epidemiol 1999;28(6):1026–31.

Lahmann PH, Lissner L, Gullberg B, Olsson H, Berglund G. A prospective study of adiposity and postmenopausal breast cancer risk: the Malmö Diet and Breast Cancer Study. Int J Cancer 2003;103(2):246–52.

Downloads

Published

2017-06-25

Most read articles by the same author(s)

1 2 3 4 5 > >>