• Shama Akram
  • Zamir Ahmed
  • Iram Fayyaz
  • Sadia Mehmood
  • Mansoor Ghani
  • Anbreen Mazhar Choudhary
  • Imran Shah


Background: Cardiovascular diseases (CVD) are the leading cause of morbidity, mortality anddisability worldwide. Leptin, a 16kDa product of ob gene, is an endocrine hormone produced by whiteadipose tissue. It is primarily involved in the regulation of food intake and energy expenditure.Hyperleptinemia is one of the novel risk factors contributing in many ways to CVD. Objective: Theobjective of the study was to find the level of leptin in patients with coronary artery disease (CAD) andcompare it with healthy people in our population. Methods: Our study was an analytical and crosssectional study. Our study included 60 patients with a history of CAD and 60 healthy controls (aged40–60 years, both sexes). Leptin levels were measured by ELISA. Results: Mean serum leptin level inpatients was 11.48±11.25 ηg/ml, while control group had a mean leptin level of 8.22±8.01 ηg/ml(p=0.071). Conclusion: Leptin levels were higher in patients but the difference was non-significant.More studies are needed with larger sample size in our population.Keywords: Coronary Artery Disease (CAD), Leptin


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