GENOTYPE VARIATION OF HEPATITIS C VIRUS IN DISTRICT BUNER SWAT
Abstract
Objective: To determine the frequency of various genotypes of Hepatitis C virus in District Buner,Swat. Methods: This Descriptive case series study was conducted at District Headquarter HospitalDaggar, and Bilal Medical Trust, Pir Baba, Swat, Pakistan from January 2007 to June 2008. Atotal of 400 patients, 154 Male and 246 Female aged 16–65 years (Mean age 31±13 years) withoutclinical and ultrasonographic evidence of cirrhosis, and with positive Hepatitis C Virus (HCV)antibodies by ELIZA, and HCV RNA detected by PCR were included. Hepatitis C virusgenotypes were checked in serum by real time PCR (RT-PCR). Results: Genotype 3 was the mostcommon type accounting for 61.5% of the study population. Amongst the subtypes, 182 (45.5%)had genotype 3a and 64 (16%) had genotype 3b. Thirty-five (8.7%) patients had genotype 1a, 12(3%) had genotype 1b. Twenty-six (6.5%) patients had genotype 2a. Four (1%) patients hadgenotype 2b. Three (0.75%) patients had genotype 4a, and 1 (0.25%) had genotype 6a. Sixty-four(16%) patients had mixed infections. Forty (10%) patients had genotype 3a and 3b, 12 (3%)patients had genotype 1a, 1b, and 9 (2.25%) patients had genotype 2a and 1c, 2 (0.5%) hadgenotype1a, 3a and 1 patient (0.25%) had genotype1a, 3b. Nine (2.25%) patients had untypablegenotype. Conclusion: Genotype 3 with its subtypes 3a and 3b is the commonest Hepatitis C viruspresent in District Buner, Swat. The others in order of decreasing frequency are genotype 1a, 2aand mixed types.Keywords: Hepatitis C virus, HCV, Genotypes, District BunerReferences
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