RELATIONSHIP OF LIPIDS, C-REACTIVE PROTEIN AND SIALIC ACID IN THE HEALTHY INDIVIDUALS

Authors

  • Mohammad Israr Bacha Khan Medical College Mardan
  • Chaman Gul AMC
  • Aziz ur Rehman -
  • Abdus Sattar Khan
  • Muhammad Siyar
  • Salma Rahim
  • Muhammad Arshad

Abstract

Background: Raised levels of cholesterol and triglycerides are major risk factors for atherosclerosis, which can lead to coronary heart disease. Both the CRP and Sialic Acid levels are elevated in response to acute as well as chronic inflammatory conditions. This study was conducted to determine the serum lipid profile, CRP and Sialic Acid levels and their relationship with each other in healthy individuals. Methods: This was a cross-sectional study performed by the Department of Biochemistry, Institute of Basic Medical Sciences (IBMS), Khyber Medical University (KMU) Peshawar. Two hundred healthy subjects in the age group of 18–50 years of either gender were recruited through consecutive sampling. Blood sampling were taken from all the participants and analysed each for serum lipid profile, CRP and Sialic Acid levels through standardized methods. Results: A total of 200 individuals were included, 53.5% being male. Mean age was 33.39±9.76 years. Mean height was 167.86±10.8 cm. Mean weight was 66.87±11.39kg. Mean Hip-Waist ratio was 0.93±0.16 whereas mean BMI was 24.12±3.65. The simultaneous raised levels of serum lipids, CRP and Sialic Acid were observed more commonly in females as compared to males. CRP and Sialic Acid has got statistically significant correlation with HDL. Sialic Acid had statistically significant correlation with triglycerides in the study population with a significant p-value (<0.05), while having a non-significant correlation with total cholesterol and LDL. CRP had got significant correlation with total cholesterol and LDL and non-significant correlation with triglycerides. Conclusion: The study showed that serum CRP and Sialic Acid had a significant negative correlation with serum HDL. A significant positive correlation was found between serum Sialic Acid and triglycerides. CRP and Sialic Acid though expensive but are useful predictors of atherosclerotic disease.               Keywords: Triglycerides; HDL; LDL; Cholesterol; CRP; Sialic Acid

Author Biographies

Mohammad Israr, Bacha Khan Medical College Mardan

Biochemistry

Chaman Gul, AMC

Biochemistry

References

Schoen F, Cotran R. The Blood Vessels. In: Kumar V, Cotran RS, Robbins SL, editors. Robbins Basic Pathology. 7th ed. New Delhi: Harcourt (India) Pvt Ltd, 2003; p.335–7.

Libby P. Atherosclerosis: the new view. Sci Am 2002;286(5):46–55.

Ross R. Atherosclerosis--an inflammatory disease. N Engl J Med 1999;340(2):115–26.

Taubes G. Cardiovascular disease. Does inflammation cut to the heart of the matter? Science 2002;296(5566):242–5.

Steel DM, Whitehead AS. The major acute phase reactants: C-reactive protein, serum amyloid P component and serum amyloid A protein. Immunol Today 1994;15(2):81–8.

Mazer SP, Rabbani LE. Evidence for C-reactive protein’s role in (CRP) vascular disease: atherothrombosis, immuno-regulation and CRP. J Thromb Thrombolysis 2004;17(2):95–105.

Francisco G, Hernández C, Simó R. Serum markers of vascular inflammation in dyslipemia. Clin Chim Acta 2006;369(1):1–16.

Danesh J, Whincup P, Walker M, Lennon L, Thomson A, Appleby P, et al. Low-grade inflammation and coronary heart disease: prospective study and updated meta-analyses. BMJ 2000;321(7255):199–204.

Pradhan AD, Manson JE, Rifai N, Buring JE, Ridker PM. C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA 2001;286(3):327–34.

Pickup JC, Crook MA. Is type II diabetes mellitus a disease of the innate immune system? Diabetologia 1998;41(10):1241–8.

Vilbergsson S, Sigurdsson G, Sigvaldason H, Sigfusson N. Coronary heart disease mortality amongst non-insulin-dependent diabetic subjects in Iceland: the independent effect of diabetes. The Reykjavik Study 17-year follow up. J Intern Med 1998;244(4):309–16.

Kannel WB, D’Agostino RB, Wilson PW, Belanger AJ, Gagnon DR. Diabetes, fibrinogen, and risk of cardiovascular disease: the Framingham experience. Am Heart J 1990;120(3):672–6.

Stary HC, Chandler AB, Glagov S, Guyton JR, Insull W Jr, Rosenfeld ME, et al. A definition of initial, fatty streak, and intermediate lesions of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Circulation 1994;89(5):2462–78.

Murray CJ, Lopez AD. Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study. Lancet 1997;349(9063):1436–42.

Libby P, Ridker PM. Inflammation and atherosclerosis: role of C-reactive protein in risk assessment. Am J Med 2004;116(Suppl 6A):S9–16.

Stary HC, Chandler AB, Dinsmore RE, Fuster V, Glagov S, Insull W Jr, et al. A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Arterioscler Thromb Vasc Biol 1995;15(9):1512–31.

Schuster H. Managing the high-risk patient: therapeutic approaches in 2002. Atherosclerosis Suppl 2003;4(1):15–20.

About Adult BMI, Healthy Weight. [Internet]. Centre for Disease Control 2014 [cited 2014 Dec 6]. Available from: http://www.cdc.gov/healthyweight/assessing/bmi/adult_bmi/index.html

Ahuja A, Basu A. Study of C-Reactive Protein Level in Patients of Acute Ischemic Stroke and Its Correlation with Serum Lipid Profile. Int J Health Sci Res 2012;2(3):40–8.

Hangloo VK, Kaul I, Zargar HU. Serum sialic acid levels in healthy individuals. J Postgrad Med 1990;36(3):140–2.

Wakabayashi I, Sakamoto K, Yoshimoto S, Masui H. Relation of serum sialic acid to lipid concentration. BMJ 1991;305(6853):562–3.

Rehnuma B, Hassan Z, Ibrahim M, Ali L. Serum levels of high sensitivity C-reactive protein and its association with lipidemic status in Bangladeshi healthy adults. J Pathol Nepal 2014;4(8):644–8.

Klisic AN, Vasiljevic ND, Simic TP, Djukic TI, Maksimovic MZ, Matic MG. Association between C-reactive protein, anthropometric and lipid parameters among healthy normal weight and overweight postmenopausal women in Montenegro. Lab Med 2014;45(1):12–6.

Nayak SB, Bhaktha G. Relationship between sialic acid and metabolic variables in Indian type 2 deabetic patients. Lipids Health Dis 2005;4:15.

Waheed P, Naveed AK, Farooq F. Levels of inflammatory markers and their correlation with dyslipidaemia in diabetics. J Coll Physicians Surg Pak 2009;19(4):207–10.

Published

2018-03-16