FREQUENCY OF OCULAR MANIFESTATIONS OF CHRONIC GRAFT VERSUS HOST DISEASE

Authors

  • Muhammad Aamir Arain
  • Muhammad Khizar Khizar Niazi
  • Muhammad Dawood Khan
  • Parvez Ahmed
  • Muhammad Afzal Naz
  • Muhammad Fayyaz

Abstract

Background: With the advancement of techniques for haematopoietic cell transplantation, thenumber of transplant survivors is increasing rapidly and so are the chances of chronic graft versushost disease (cGVHD). The ocular manifestations of this disease have not been explored in ourlocal population. This study was conducted to determine the frequency of ocular complications incases of cGVHD following successful bone marrow transplantation. Methods: Twelve diagnosedcases of cGVHD were evaluated from June 2008 to March 2009 and there ocular manifestationswere noted especially the ocular surface disorders, using double staining method with fluoresceinand rose-bengal. Results: Nine patients (75%) were having dry eyes, 7 (58.3%) with mebomianglands dysfunction, 4 (33%) with acute conjunctivitis, 2 (16.7%) with bilateral lacrimalcanalicular occlusion, and 1 (8.3%) each of bilateral posterior subcapsular cataract, unilateralsterile corneal epithelial defect, anterior uveitis, retinal haemorrhages and disc oedema.Conclusion: The higher frequency of dry eyes along with other ocular manifestations in patientsof cGVHD suggests the need of close ophthalmic monitoring in all such cases.Keywords: Dry eyes, chronic graft versus host disease, haematopoietic cell transplantation

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Published

2010-03-01