THROMBOCYTOPENIA IN PLASMODIUM FALCIPARUM MALARIA
AbstractBackground: Malaria is usually associated with reduced blood cell counts & mild to moderatethrombocytopenia is a common association of malaria. The cause of thrombocytopenia is poorlyunderstood, but the immune-mediated lysis, sequestration in the spleen and dyspoietic processes inthe marrow with diminished platelet production have all been postulated. This study wasconducted to evaluate thrombocytopenia in the patients suffering from acute Plasmodiumfalciparum malaria. Methods: This descriptive case series study was conducted at a tertiary carehospital, Liaquat University of Medical & Health Sciences Jamshoro, over a one-year period. Atotal of 370 Plasmodium falciparum positive on peripheral blood film were studied. Full bloodcounts were determined by using automated Coulter analyzer. Thick & thin smears were stainedwith Giemsa stains and studied by haematologist. Data was analyzed using the SPSS version 10.0.Results: Out of 370 patients, 260 were male & 110 were female, with M:F ratio of 2.36:1. Meanage was 34±1.7 years (range 16-53 years). Haemoglobin values were 12.7±1.4g% and white bloodcells counts were found 12600±450/µL. Out of 370, 114 (30.81%) had normal platelet counts, and256 (69.18%) had thrombocytopenia (p<0.05). The mild, moderate and severe thrombocytopeniawere found in 39 (10.5%), 180 (48.6%) and 37 (10%) respectively (p<0.05). Conclusions: Wefound high frequency of mild to moderate thrombocytopenia in the Plasmodium falciparummalaria. Finding of thrombocytopenia is of diagnostic help as it raises the suspicion of malaria.Keywords: Thrombocytopenia, Malaria, Plasmodium falciparum
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