HYPOCELLULAR MYELODYSPLASTIC SYNDROME PRESENTING AS MEGALOBLASTIC ANEMIA

Authors

  • Osama Ishtiaq
  • Muhammad Zahid
  • Haider Baqai
  • Muhammad Umer
  • Atifa Shoaib
  • Kaukab Bashir

Abstract

Myelodysplastic Syndromes (MDS) are a heterogenous group of clonal stem cell disorders which generally occur in older adults but may also affect children. The ineffective hematopoiesis which causes bone marrow failure is accompanied by peripheral blood cytopenia1. MDS are classified into 5 different morphologic categories according to French-American-British (FAB) classification1,2,3. Hypocellular Myelodysplasia is a less common variant of MDS, characterized by hypocellular marrow in which a small proportion of blasts may be seen usually with occasional blasts in the peripheral blood2. We have encountered a distinct young patient of hypocellular MDS presented as megaloblastic anemia and pancytopenia. 

References

Schmitt-Graeff A, Mattern D, Kohler H, Hezel J, Lubbert M. Myelodysplastic syndromes (MDS). Aspects of haematopathologic diagnosis. Pathologe 2000;21(1):1-15.

Gordon-Smith EC. Aplastic anaemia. In: Weatherall DJ, Ledinghim JG, Warrell DA. Oxford textbook of Medicine. 3rd ed. Oxford: Oxford University Press;1996:3447.

Malaspina CH, O’Reilly JR. Myelodysplastic syndromes. In: Fauci AS, Braunwald E, Wilson DJ, Martin BJ, Kasper, Hauser SL, eds. Harrison’s Priniciples of Internal Medicine. 14th ed. New York: McGraw-Hill; 1998:678.

Drabick JJ, Davis BJ, Byrd JC. Concurrent pernicious anaemia and myelodysplastic syndrome. Ann Hematol 2001;80(4):243-5.

Lorand-Metze I, Meira DG, Lima CS, Vassallo J, Metze K. The differential diagnosis between aplastic anaemia and hypocellular myelodysplasia in patients with pancytopenia. Haematologica 1999;84(6):564-5.

Barrett J, Saunthararajah Y, Molldrem J. Myelodysplastic syndrome and aplastic anaemia: distinct entities or diseases linked by a common pathophysiology? Semin Hematol 2000;37(1):15-29.

Elghetany MT, Hudnall SD, Gardner FH. Peripheral blood picture in primary hypocellular refractory anaemia and idiopathic acquired aplastic anaemia: an additional tool for differential diagnosis. Haematologica 1997;82(1):21-4.

Varma N, Varma S, Marwaha N, Garewal G. Aplastic anaemia versus hypocellular myelodysplastic syndrome. Indian J Cancer 1995;32(3):110-5.

Toyama K, Ohyashiki K, Yoshida Y, Abe T, Asano S, Hirai H, et al. Clinical and cytogenetic findings of myelodysplastic syndromes showing hypocellular bone marrow or minimal dysplasia, in comparison with typical myelodysplastic syndromes. Int J Hematol 1993;58(1-2):53-61.

Issue

Vol. 14 No. 3 (2002): JOURNAL OF AYUB MEDICAL COLLEGE, ABBOTTABAD

Section

CASE REPORT

License

Journal of Ayub Medical College, Abbottabad is an OPEN ACCESS JOURNAL which means that all content is FREELY available without charge to all users whether registered with the journal or not. The work published by J Ayub Med Coll Abbottabad is licensed and distributed under the creative commons License  CC BY ND Attribution-NoDerivs. Material printed in this journal is OPEN to access, and are FREE for use in academic and research work with proper citation. J Ayub Med Coll Abbottabad accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing in J Ayub Med Coll Abbottabad. The Editorial Board of J Ayub Med Coll Abbottabad makes every effort to ensure the accuracy and authenticity of material printed in J Ayub Med Coll Abbottabad. However, conclusions and statements expressed are views of the authors and do not reflect the opinion/policy of J Ayub Med Coll Abbottabad or the Editorial Board.

USERS are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.

AUTHORS retain the rights of free downloading/unlimited e-print of full text and sharing/disseminating the article without any restriction, by any means including twitter, scholarly collaboration networks such as ResearchGate, Academia.eu, and social media sites such as Twitter, LinkedIn, Google Scholar and any other professional or academic networking site.

Most read articles by the same author(s)