FINE NEEDLE ASPIRATION CYTOLOGY OF THYROID NODULE: DIAGNOSTIC ACCURACY AND PITFALLS
AbstractObjective : To evaluate the utility of FNAC in patients with Thyroid Nodule. Methods : Recordsof all patients treated surgically for thyroid nodule(s) at Aga Khan University Hospital fromJanuary 2000 to December 2004 were reviewed. The patients who had pre operative FNAC as firstline of the evaluation and the final post operative histopathology report available were included inthe study. Results: 125 patients (90 female 35 male) had thyroid surgery. The cytologicaldiagnosis was made according to following categories: Benign, Follicular lesion, Malignant andInadequate sampling. Among 63 “Benign cases”, 57 were benign and 6 turned out to bemalignant. Among 44 cases from “Follicular group”, 31 were benign and 13 were malignant. Outof 15 patients from “Malignant” group, 14 were malignant and 1 was benign. Among threepatients from the “Inadequate sampling group”, 2 turned out to be benign and one was malignant.The overall results showed a sensitivity of 98%, specificity of 70%, and positive predictive valueof 91%, negative predictive value of 93% and diagnostic accuracy of 91%. Conclusion: Weconclude that FNAC is an invaluable and minimally invasive procedure for pre operativeassessment of patients with a thyroid nodule in our setting as well. FNAC has high sensitivity inpicking up malignancy in thyroid and also has high diagnostic accuracy in the evaluation ofthyroid nodules.Keywords : Thyroid – FNAC - Histopathology
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