• Abdul Rahman
  • Jawed Aftab
  • Rehan Majeed
  • Anila Jaleel
  • Fasia Basir
  • Sultan Shah
  • RA Khan


Background: Cardiovascular disease is common cause of death in developed as well asdeveloping countries. The most common cause of Ischemic Heart disease is narrowing of coronaryarteries, a process called as atherosclerosis. The objective of the present study is to determine thepattern of ischemic changes detected by technetium tetrofosmin (Tc99m). Methods: Sixty fivepatients presenting as known or suspected ischemic heart disease over a period of two years(December 1995 to December 1998) at Ziauddin Hospital were included in the study. Each patientunderwent Tc99m tetrofosmin stress and rest studies. Tetrofosmin study was performed accordingto one day protocol. Results: By segmental analysis (five segment per patient), 35 patients hadperfusion defects by SPECT Tc99m tetrofosmin imaging. Out of 95 perfusion defects, reversibleischemia and mixed defects were more common in inferior wall and fixed defect in left ventricularapex. Conclusion: Reversible ischemia and mixed defects were more common in inferior wall andfixed defect in left ventricular apex.Key words: Reversible, Ischemia, Imaging, Fixed Defects, Myocardial perfusion,


Schuijf JD, Shaw LJ, Wijns W, Lames HJ, Poldermans D,

Roos A, et al. Cardiac Injury in coronary artery disease:

differing modalities. Heart 2005;91:1110-7

Hanson M, Gluckman M. Endothelial dysfunction and

cardiovascular disease: the role of predictive adaptive

response. Heart 2005;91:864-6

French JK, Harvey WD. Clinical implications of the new

definition of myocardial infarction. Heart 2004;90:99-106

Kelion AD, Underwood SR. Myocardial perfusion

scintigraphy in the UK: how much are we doing and how

can we do more. Heart 2005;91: iv

Marcelo F, Di Carli, MD, Dorbala S. Exercise testing and

nuclear scanning. Circulation. 2003;107:100-3

Xiang ZHe , Fang RShi , Jian YWu , Tian YQ , Liu XJ ,

Wang SW, et al. Direct imaging of exercise-induced

myocardial ischemia with Fluorine-18-labeled Deoxyglucose

and Tc-99m-Sestamibi in coronary artery disease. Circulation

; 108:1208-10

Samady H, Hawa Y, Choi J et al. Electromechanical mapping

for detecting myocardial viability and ischemia in patients

with severe ischemic cardiomyopathy. Am J Cardiol 2003;

: 807-11

Gould KL, Taegtmeyer H, He ZX, Shi Rf, Wu YJ, Tian YQ,

et al. Myocardial ischemia, Fluorodeoxyglucose and severity

of coronary artery stenosis: the complexities of metabolic

remodeling in hibernating myocardium response.

Circulation 2004;109(12):167-70.