COMPARISON OF TROPONIN T AND ENZYME LEVELS IN ACUTE MYOCARDIAL INFARCTION AND SKELETAL MUSCLE INJURY
AbstractBackground: The objective of this study was to compare the levels of troponin T and enzymes levels in myocardial infarction and skeletal muscle injury. Methods: This study was carried out at Basic Medical Sciences Institute, JPMC Karachi, Pakistan. Ninety subjects were selected. Thirty controls, thirty patients suffering from myocardial infarction and thirty suffering from skeletal muscle injury were selected from National Institute of Cardiovascular Diseases. Creatine kinase, aspartate amino-transferase, lactate dehydrogenase and Troponin T were determined by kit methods. Results: Troponin T level rises significantly (p<0.01) in patients suffering from myocardial infarction. Creatine kinase (CK), CKMB, aspartate aminotransferase and lactate dehydrogenase levels rises significantly (p<0.01) in both groups compared with controls. Conclusion: Troponin T is an early indicator of myocardial infarction and is superior to CKMB in diagnosis of myocardial injury. There is no increase in troponin T levels in skeletal muscle injury.Key words: Troponin T, Acute, Myocardial infarction, Skeletal, muscle, injuries
Sobel BE. Acute myocardial infarction. In Cecil Textbook of Medicine W.B. Saunders Company London. 20th edition (1), 1996; pp. 301.
Braunwald E. Diseases of the heart, aorta and pulmonary vascular bed. In: Heart Disease. W.B. Saunders Company Philadelphia, 1997; pp. 877-1642.
Schreiber WE. Laboratory assessment of myocardial damage. Am J Clin Path 1997; 107(4): 383-4.
Lott JA, Stang JM. Serum enzyme and isoenzyme in the diagnosis and differential diagnosis of myocardial ischemia and necrosis. Clin Chem 1980; 26: 1241-50.
Vessel ES, Bean AG. Localization of lactic acid dehydrogenase activity in serum fractions. 1957, Proceedings of the Society of Exp Biol Med; 94: 96-99.
Collinson PO, Mosley D, Stubbs PJ, Carter GD. Troponin T for differential diagnosis of ischemic myocardial damage. Am Clin Biochem 1993;30: 11-16
Wu AHB, Valdes JR, Apple FS, Gornet T, Stone MA, Stokes MS, et al. Cardiac Troponin T immunoassay for diagnosis of acute myocardial infarction. Clin Chem 1994;40 (6): 900-907
Wu AHB, Lane PL. Meta analysis in clinical chemistry: Validation of cardiac Troponin T as a marker for ischemic heart diseases. Clin Chem 1995; 41/8(b):1288-1233.
Brown CS, Bertolet BD. Cardiac troponin. Chest 1997;111/1:2-4
Mulner M, Hirschl MM, Herkner H, Sertz F, Leitha T, Exner M et al. Creatine Kinase MB fraction and cardiac troponin T to diagnose acute myocardial infarction after cardiopulmonary resuscitation. JACC 1996;28(5):1220-5
Apple FS. Acute myocardial infarction and coronary reperfusion. AJCP 1992; 97(2): 217-226.
Badroff MM, Hallermayor KI, Schroder A, Ebert C, Borgya A, Gerhardt W. Improved troponin T ELISA specific for cardiac troponin T isoform assay development and analytical clinical validation. Clin Chem 1997;43(3): 458-66.
Collinson PO, Chandler HA, Stubbs PJ, Moseley DS, Levis D and Suman MD. Measurement of serum troponin T, creatine kinase MB isoenzyme and total creatine kinase following ardous physical training. Ann Clin Biochem 1995; 32:445-50.
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