CORRELATION OF QUALITY OF LIFE IN PATIENTS OF CIRRHOSIS OF LIVER WITH ETIOLOGY AND DISEASE SEVERITY USING DISEASE-SPECIFIC QUALITY OF LIFE QUESTIONNAIRE
AbstractBackground: Quality of Life has an important status in patient management suffering fromchronic disease like cirrhosis and health related quality of life has significant impact on patientmanagement. This study was conducted to evaluate the correlation of health related quality of lifewith disease severity in patients of cirrhosis of liver. Methods: This cross-sectional study wasconducted at Medical Unit -IV, Dow University of Health Sciences, Karachi, during the periodJanuary 2006 to October 2006. All patients of cirrhosis of liver admitted during the study periodwere selected. Patients with encephalopathy, hepatocellular carcinoma were excluded. The 29 itemchronic liver disease questionnaire (CLDQ) was administered to the patients by a postgraduatetrainee. Internal validity of responses was checked statistically and correlation of responses wasdone with disease severity by Child-Pughs Criteria. Results: 109 patients were selected with 72males and 37 females. Patient classification according to Child class A, B & C was 30, 38 & 41respectively. The mean CLDQ score in the patients was 89.5 ±30.4. It correlated significantly withChild Class but did not correlate with the gender, age and etiology of cirrhosis. Conclusion:Health related CLDQ scores correlate with the severity of liver disease.Keywords: Cirrhosis; Chronic liver disease; Quality of life; Health quality of life.related
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