• Badaruddin Sahito Dr. Ruth KM Pfau Civil Hospital Karachi
  • Nadia Nazir Jatoi Dow University of Health Sciences, Karachi
  • Dileep Kumar Dr. Ruth KM Pfau Civil Hospital Karachi
  • Ameema Asad Dow Medical College, Dow University of Health Sciences, Karachi
  • Syed Saboor Hasan Dow Medical College, Dow University of Health Sciences, Karachi
  • Maratib Ali Department Orthopaedic Surgery, Dow University of health sciences, Karachi-Pakistan


Adamantinoma is a rare neoplastic bone tumor that has the potential to metastasize. The classic presentation is in the tibial region however; cases involving other bones of the body have been noticed. The tumour is very likely to be mistaken for other bone diseases and therefore it is important to investigate and study about its nature and thus differentiate it from other differentials. Nevertheless, literature on the presentation, findings, investigations and treatment options of adamantinomas are limited. In this case series, we report four cases from a local hospital in Karachi who were diagnosed, treated and followed up for adamantinoma. Studies regarding the disease will help us understand more about its features.


Jain D, Jain VK, Vasishta RK, Ranjan P, Kumar Y. Adamantinoma: A clinicopathological review and update. Diagn Pathol 2008;3:8.

Mirra JM. Adamantinoma and osteofibrous dysplasia. In: Bone tumors: clinical, radiologic and pathologic correlation, 1989; p.1203–31.

Van Rijn R, Bras J, Schaap G, van den Berg H, Maas M. Adamantinoma in childhood: report of six cases and review of the literature. Pediatr Radiol 2006;36(10):1068–74.

Szendroi M, Antal I, Arató G. Adamantinoma of Long Bones: A Long-term Follow-up Study of 11 Cases. Pathol Oncol Res 2009;15(2):209–16.

Keeney GL, Unni KK, Beabout JW, Pritchard DJ. Adamantinoma of long bones. A clinicopathologic study of 85 cases. Cancer 1989;64(3):730–7.

Qureshi AA, Shott S, Mallin BA, Gitelis S. Current trends in the management of adamantinoma of long bones. An international study. J Bone Joint Surg Am 2000;82(8):1122–31.

Liman AD, Liman AK, Shields J, Englert B, Shah R. A Case of Metastatic Adamantinoma That Responded Well to Sunitinib. Case Rep Oncol Med 2016;2016:5982313.

Czerniak B, Rojas-Corona RR, Dorfman HD. Morphologic diversity of long bone adamantinoma. The concept of differentiated (regressing) adamantinoma and its relationship to osteofibrous dysplasia. Cancer 1989;64(11):2319–34.

Tharmabala M, Kandapur V, Senger JL, Kanthan R. Diagnostic pitfalls in tibial adamantinoma: two cases with a clinicopathological review. Clin Pract 2011;1(4):e138.

McCarthy E. Adamantinoma. In: Santini-Araujo E, Kalil RK, Bertoni F, Park YK, editors. Tumors and Tumor-Like Lesions of Bone. Springer, London; 2015.

Houdek MT, Sherman CE, Inwards CY, Wenger DE, Rose PS, Sim FH. Adamantinoma of bone: Long-term follow-up of 46 consecutive patients. J Surg Oncol 2018;118(7):1150–4.

Limaiem F, Tafti D, Malik A. Adamantinoma. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 [cited 2020 Aug]. Available from: http://www.ncbi.nlm.nih.gov/books/NBK538175/

Unni KK, Dahlin DC, Beabout JW, Ivins JC. Adamantinomas of long bones. Cancer 1974;34(5):1796–805.

Puchner SE, Varga R, Hobusch GM, Kasparek M, Panotopoulos J, Lang S, et al. Long-term outcome following treatment of Adamantinoma and Osteofibrous dysplasia of long bones. Orthop Traumatol Surg Res 2016;102(7):925–32.

Kuruvilla G, Steiner GC. Osteofibrous dysplasia-like adamantinoma of bone: a report of five cases with immunohistochemical and ultrastructural studies. Hum Pathol 1998;29(8):809–14.