FREQUENCY OF METABOLIC SYNDROME IN PATIENTS WITH PSORIASIS
Keywords:
Body mass Index, Psoriasis, Metabolic SyndromeAbstract
Background: Psoriasis is a non-communicable, long-lasting disorder of the skin comprising various immunological inflammatory changes. Increasing evidence suggests that psoriasis is closely related to multiple organ systems, potentially arising due to underlying co-morbid conditions such as diabetes, hypertension, dyslipidaemia and obesity. Aim of this study was to know the frequency of metabolic syndrome in psoriasis patients. Methods: This cross-sectional study was conducted from May to November 2020 in a Tertiary-care hospital. 80 patients diagnosed with psoriasis were selected using non-probability consecutive sampling. Informed written consent was obtained from each patient and a questionnaire was filled. Blood pressure, waist circumference, body surface area covered by psoriasis, Psoriasis Area Severity Index were recorded on initial visit. Fasting blood sugar, serum triglyceride and HDL cholesterol levels were advised. Patients were diagnosed to have metabolic syndrome if ‰¥3 out of 5 criteria for the modified version of National Cholesterol Education Program Adult Panel III were met. Results: There were 62 male and 18 female patients. A total of 39 patients (48.8%) met the criteria for metabolic syndrome. Amongst these, 26/62 (41.9%) males vs 13/18 (72.2%) females fulfilled the criteria. The mean BMI of males was 26.0 while those of females was 28.3, comparison of which demonstrated a noteworthy difference (p=0.04). A statistically significant (p=0.038) positive correlation (r) of 0.233 was observed between body surface area and BMI. Conclusion: Metabolic syndrome is seen frequently in patients of Psoriasis. Female patients have a significant frequency of metabolic syndrome and tend to have a higher BMI than males.
References
Schleicher SM. Psoriasis: pathogenesis, assessment, therapeutic update. Clin Podiatr Med Surg 2016;33(3):355-66.
Griffiths CEM, van der Walt JM, Ashcroft DM, Flohr C, Naldi L, Nijsten T, et al. The global state of psoriasis disease epidemiology: a workshop report. Br J Dermatol 2017;177(1):e4-7.
Michalek IM, Loring B, John SM. A systematic review of worldwide epidemiology of psoriasis. J Eur Acad Dermatol Venereol 2017;31(2):205-12.
Hawkes JE, Chan TC, Krueger JG. Psoriasis pathogenesis the development of novel targeted immune therapies. J Allergy Clin Immunol 2017;140(3):645-53.
Ogawa E, Sato Y, Minagawa A, Okuyama R. Pathogenesis of psoriasis development of treatment. J Dermatol 2018;45(3):264-72.
McCracken E, Monaghan M, Sreenivasan S. Pathophysiology of the metabolic syndrome. Clin Dermatol 2018;36(1):14-20.
Singh S, Young P, Armstrong AW. An update on psoriasis metabolic syndrome: A meta-analysis of observational studies. PLoS One 2017;12(7):e0181039.
Gisondi P, Fostini AC, Fossà I, Girolomoni G, Targher G. Psoriasis the metabolic syndrome. Clin Dermatol 2018;36(1):21-8.
Manolis AA, Manolis TA, Melita H, Manolis AS. Psoriasis cardiovascular disease: the elusive link. Int Rev Immunol 2019;38(1):33-54.
Setty AR, Curhan G, Choi HK. Obesity, waist circumference, weight change, the risk of psoriasis in women: Nurses' Health Study II. Arch Intern Med 2007;167(15):1670-5.
Lan Y, Mai Z, Zhou S, Liu Y, Li S, Zhao Z, et al. Prevalence of metabolic syndrome in China: An up-dated cross-sectional study. PloS One 2018;13(4):e0196012.
Coimbra S, Oliveira H, Reis F, Belo L, Rocha S, Quintanilha A, et al. Circulating levels of adiponectin, oxidized LDL C-reactive protein in Portuguese patients with psoriasis vulgaris, according to body mass index, severity duration of the disease. J Dermatol Sci 2009;55(3):202-4.
Wang Y, Chen J, Zhao Y, Geng L, Song F, Chen HD. Psoriasis is associated with increased levels of serum leptin. Br J Dermatol 2008;158(5):1134-5.
Jensen P, Skov L. Psoriasis obesity. Dermatology 2016;232(6):633-9.
Gisondi P, Tessari G, Conti A, Piaserico S, Schianchi S, Peserico A, et al. Prevalence of metabolic syndrome in patients with psoriasis: a hospital-based case-control study. Br J Dermatol 2007;157(1):68-73.
Ghias A, Khan MS, Shaheen E. Frequency of metabolic syndrome in patients of psoriasis. J Pak Assoc Dermatol 2018;28(1):73-8.
Hassan BS, Akhtar N, kumar Paul H, Biswas C, Hossain MA, Wahab MA, et al. Rate of metabolic syndrome in psoriasis. J Pak Assoc Dermatol 2017;27(1):48-53.
Azfar NA, Malik LM, Khan IU, Ahsan U, Rashid T, Jahangir M. Frequency of Metabolic Syndrome in patients of Psoriasis. J Allama Iqbal Med Coll 2019,17(01) 145-7.
Downloads
Published
How to Cite
Issue
Section
License
Journal of Ayub Medical College, Abbottabad is an OPEN ACCESS JOURNAL which means that all content is FREELY available without charge to all users whether registered with the journal or not. The work published by J Ayub Med Coll Abbottabad is licensed and distributed under the creative commons License CC BY ND Attribution-NoDerivs. Material printed in this journal is OPEN to access, and are FREE for use in academic and research work with proper citation. J Ayub Med Coll Abbottabad accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing in J Ayub Med Coll Abbottabad. The Editorial Board of J Ayub Med Coll Abbottabad makes every effort to ensure the accuracy and authenticity of material printed in J Ayub Med Coll Abbottabad. However, conclusions and statements expressed are views of the authors and do not reflect the opinion/policy of J Ayub Med Coll Abbottabad or the Editorial Board.
USERS are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.
AUTHORS retain the rights of free downloading/unlimited e-print of full text and sharing/disseminating the article without any restriction, by any means including twitter, scholarly collaboration networks such as ResearchGate, Academia.eu, and social media sites such as Twitter, LinkedIn, Google Scholar and any other professional or academic networking site.
