• Mohammad Harisullah Khan Aga Khan University
  • Ramsha Kashif Aga Khan University
  • Hamza Abdur Rahim Khan Aga Khan University
  • Saulat Hasnain Fatimi Aga Khan University


Myxoid liposarcomas of the head and neck are mostly metastatic in nature, with the primary lesion usually in lower extremities or retroperitoneum. Primary mediastinal liposarcomas are even rarer. Although there have been previous cases reporting their incidence, there is no evidence of any case comprising of both the neck and the mediastinal region yet. We here present a case of a 43 year old male with a primary liposarcoma of the myxoid subtype originating in the anterior mediastinum. This is the first time such a case has presented in literature. The patient presented with a right sided neck swelling associated with pain and shortness of breath upon lying down. CT neck revealed an enhancing mass extending from right cervical region to axilla and encasing the subclavian artery and involving a portion of the right lung. The patient underwent wide local excision of the mass along with chemoradiotherapy to prevent recurrence.Keywords: Myxoid; liposarcoma; soft tissue sarcomas; head and neck

Author Biographies

Mohammad Harisullah Khan, Aga Khan University

Fourth Year Medical Student

Ramsha Kashif, Aga Khan University

Fourth Year Medical Student

Hamza Abdur Rahim Khan, Aga Khan University

Fourth Year Medical Student

Saulat Hasnain Fatimi, Aga Khan University

Cardiothoracic Surgeon


Srivastava A, Ghosh A, Saha S, Saha VP, Chakraborty D. Sarcomas of head and neck - A 10 yrs experience. Indian J Otolaryngol Head Neck Surg 2007;59(4):322–6.

Barile A, Zugaro L, Catalucci A, Caulo M, Di Cesare E, Splendiani A, et al. Soft tissue liposarcoma: histological subtypes, MRI and CT findings. Radiol Med 2002;104(3):140–9.

Spittle MF, Newton KA, Mackenzie DH. Liposarcoma. A review of 60 cases. Br J Cancer 1970;24(4):696–704.

McMains CK, Gourin CG. Pathology: Sarcomas of the Head and Neck. 2009. [Internet]. [Cited 2016 Feb 28]. Available from:

Schwartz RA, Centurion SA. Liposarcoma: Drugs and Diseases. [Internet] 2016 [cited 2016 Feb 28]. Available from:

Russell WO, Cohen J, Enzinger F, Hajdu SI, Heise H, Martin RG, et al. A clinical and pathological staging system for soft tissue sarcomas. Cancer 1977;40(4):1562–70.

Hahn HP, Fletcher CD. Primary mediastinal liposarcoma: clinicopathologic analysis of 24 cases. Am J Surg Pathol 2007;31(12):1868–74.

Dei Tos AP. Liposarcoma: new entities and evolving concepts. Ann Diagn Pathol 2000;4(4):252–66.

Reitan JB, Kaalhus O, Brennhovd IO, Sager EM, Stenwig AE, Talle K. Prognostic factors in liposarcoma. Cancer 1985;55(10):2482–90.

Fletcher CDM, Unni KK, Mertens F, editors. World Health Organization classification of tumors. Pathology and genetics of tumours of soft tissue and bone. IARC Press; Lyon 2002.

Ruacan S, Onerci M, Gedikoglu G, Dal T. Liposarcoma of the cheek: report of a case. J Oral Pathol Med 1993;22(1):46–7.

Eeles RA, Fisher C, A'Hern RP, Robinson M, Rhys-Evans P, Henk JM, et al. Head and neck sarcomas: prognostic factors and implications for treatment. Br J Cancer 1993;68(1):201–7.

Freedman AM, Reiman HM, Woods JE. Soft tissue sarcomas of the head and neck. Am J Surg 1989(158):367–72.

Zagars GK, Goswitz MS, Pollack A, Liposarcoma: outcome and prognostic factors following conservation surgery and radiation therapy. Int J Radiat Oncol Biol Phys 1996;36(2):311–9.