APPETITE REGULATION IN RELATION TO ENERGY PROVISION

Authors

  • Sadia Fatima KMU, Peshawar
  • Nasir Ahmed Ayub Medical College
  • Fozia Fatima Ayub Medical College, Abbottabad
  • Salim Wazir Ayub Medical College, Abbottabad

Abstract

Background: Appetite control is a very complex process which influences the short term feeding behaviour and a long term adaptive process that responds to the energy input. Appetite control and food intake is influenced by a combination of behavioural, psychological and neuro-endocrine influences. Methods: For identification of articles search engines of the databases EMBASE, OVID, Pub med and MEDLINE were used for papers published from 2002 to 2015 in English language. Results: The higher endogenous peptide YY (PYY) and cholecystokinin (CCK) and lower ghrelin levels are not always associated with subjective feelings of fullness or hunger and a decreased energy intake which highlights the fact that appetite control and food intake is a very intricate process. Conclusion: When food is ingested, numerous physiological, hormonal, social and psychological processes are triggered in an intricate manner. Therefore, it can be said that ghrelin, PYY and CCK are just few pieces, which contributes to the process of appetite control and energy intake.Keywords: Appetite, appetite hormones, ghrelin, CCK, PYY, control of energy intake

References

Blundell J, de Graaf C, Hulshof T, Jebb S, Livingstone B, Lluch A, et al. Appetite control: methodological aspects of the evaluation of foods. Obes Rev 2010;11(3):251–70.

Mattes RD, Hollis J, Hayes D, Stunkard AJ. Appetite: measurement and manipulation misgivings. J Am Diet Assoc 2005;105(5):87–97.

Geraedts MCP, Troost F, Saris W. Gastrointestinal targets to modulate satiety and food intake. Obes Rev 2011;12(6):470–7.

Halton TL, Hu FB. The effects of high protein diets on thermogenesis, satiety and weight loss: a critical review. J Am Coll Nutr 2004;23(5):373–85.

Delzenne N, Blundell J, Brouns F, Cunningham K, De Graaf K, Erkner A, et al. Gastrointestinal targets of appetite regulation in humans. Obes Rev 2010;11(3):234–50.

Melanson KJ, Westerterp-Plantenga MS, Saris WHM, Smith FJ, Campfield LA. Blood glucose patterns and appetite in time-blinded humans: carbohydrate versus fat. Am J Physiol 1999;277(2 Pt 2):R337–45.

Flint A, Raben A, Blundell J, Astrup A. Reproducibility, power and validity of visual analogue scales in assessment of appetite sensations in single test meal studies. Int J Obes Relat Metab Disord 2000;24(1):38–48.

Huda MS, Wilding JP, Pinkney JH. Gut peptides and the regulation of appetite. Obes Rev 2006;7(2):163–82.

Sobrino Crespo C, Perianes Cachero A, Puebla Jiménez L, Barrios V, Arilla Ferreiro E. Peptides and food intake. Front Endocrinol (Lausanne) 2014;5:58.

Wynne K, Stanley S, McGowan B, Bloom S. Appetite control. J Endocrinol 2005;184(2):291–318.

Le Roux CW, Bloom SR. Peptide YY, appetite and food intake. Proc Nutr Soc 2005;64(02):213–6.

Cowley MA, Smith RG, Diano S, Tschöp M, Pronchuk N, Grove KL, et al. The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron 2003;37(4):649–61.

Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999;402(6762):656–60.

Sakata I, Tanaka T, Matsubara M, Yamazaki M, Tani S, Hayashi Y, et al. Postnatal changes in ghrelin mRNA expression and in ghrelin-producing cells in the rat stomach. J Endocrinol 2002;174(3):463–71.

Korbonits M, Bustin SA, Kojima M, Jordan S, Adams EF, Lowe DG, et al. The expression of the growth hormone secretagogue receptor ligand ghrelin in normal and abnormal human pituitary and other neuroendocrine tumors. J Clin Endocrinol Metab 2001;86(2):881–7.

Volante M, Fulcheri E, Allìa E, Cerrato M, Pucci A, Papotti M. Ghrelin expression in fetal, infant, and adult human lung. J Histochem Cytochem 2002;50(8):1013–21.

Volante M, AllÌa E, Gugliotta P, Funaro A, Broglio F, Deghenghi R, et al. Expression of ghrelin and of the GH secretagogue receptor by pancreatic islet cells and related endocrine tumors. J Clin Endocrinol Metab 2002;87(3):1300–8.

Takaya K, Ariyasu H, Kanamoto N, Iwakura H, Yoshimoto A, Harada M, et al. Ghrelin strongly stimulates growth hormone release in humans. J Clin Endocrinol Metab 2000;85(12):4908–11.

Date Y, Toshinai K, Koda S, Miyazato M, Shimbara T, Tsuruta T, et al. Peripheral interaction of ghrelin with cholecystokinin on feeding regulation. Endocrinology 2005;146(8):3518–25.

Wierup N, Svensson H, Mulder H, Sundler F. The ghrelin cell: a novel developmentally regulated islet cell in the human pancreas. Regul Pept 2002;107(1-3):63–9.

Asakawa A, Inui A, Kaga O, Yuzuriha H, Nagata T, Ueno N, et al. Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin. Gastroenterology 2001;120(2):337–45.

Masuda Y, Tanaka T, Inomata N, Ohnuma N, Tanaka S, Itoh Z, et al. Ghrelin stimulates gastric acid secretion and motility in rats. Biochem Biophys Res Commun 2000;276(3):905–8.

Cummings DE, Purnell JQ, Frayo RS, Schmidova K, Wisse BE, Weigle DS. A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 2001;50(8):1714–9.

Cummings DE, Foster-Schubert KE, Overduin J. Ghrelin and energy balance: focus on current controversies. Curr Drug Targets 2005;6(2):153–69.

Callahan HS, Cummings DE, Pepe MS, Breen PA, Matthys CC, Weigle DS. Postprandial suppression of plasma ghrelin level is proportional to ingested caloric load but does not predict intermeal interval in humans. J Clin Endocrinol Metab 2004;89(3):1319–24.

Blom WAM, Lluch A, Stafleu A, Vinoy S, Holst JJ, Schaafsma G, et al. Effect of a high-protein breakfast on the postprandial ghrelin response. Am J Clin Nutr 2006;83(2):211–20.

Foster-Schubert KE, Overduin J, Prudom CE, Liu J, Callahan HS, Gaylinn BD, et al. Acyl and total ghrelin are suppressed strongly by ingested proteins, weakly by lipids, and biphasically by carbohydrates. J Clin Endocrinol Metab 2008;93(5):1971–9.

Bowen J, Noakes M, Trenerry C, Clifton PM. Energy intake, ghrelin, and cholecystokinin after different carbohydrate and protein preloads in overweight men. J Clin Endocrinol Metab 2006;91(4):1477–83.

Latner JD, Schwartz M. The Effects of a High-carbohydrate, High-protein or Balanced Lunch upon Later Food Intake and Hunger Ratings. Appetite 1999;33(1):119–28.

Hansen TK, Dall R, Hosoda H, Kojima M, Kangawa K, Christiansen JS, et al. Weight loss increases circulating levels of ghrelin in human obesity. Clin Endocrinol (Oxf) 2002;56(2):203–6.

Hellstrom PM, Geliebter A, Naslund E, Schmidt PT, Yahav EK, Hashim SA, et al. Peripheral and central signals in the control of eating in normal, obese and binge-eating human subjects. Br J Nutr 2004;92:47–57.

Tschöp M, Weyer C, Tataranni PA, Devanarayan V, Ravussin E, Heiman ML. Circulating ghrelin levels are decreased in human obesity. Diabetes 2001;50(4):707–9.

English PJ, Ghatei MA, Malik IA, Bloom SR, Wilding JP. Food fails to suppress ghrelin levels in obese humans. J Clin Endocrinol Metab 2002;87(6):2984.

Druce MR, Wren AM, Park AJ, Milton JE, Patterson M, Frost G, et al. Ghrelin increases food intake in obese as well as lean subjects. Int J Obes 2005;29(9):1130–6.

Shimizu Y, Nagaya N, Isobe T, Imazu M, Okumura H, Hosoda H, et al. Increased plasma ghrelin level in lung cancer cachexia. Clin Cancer Res 2003;9(2):774–8.

Itoh T, Nagaya N, Yoshikawa M, Fukuoka A, Takenaka H, Shimizu Y, et al. Elevated plasma ghrelin level in underweight patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2004;170(8):879–82.

Wren AM, Seal LJ, Cohen MA, Brynes AE, Frost GS, Murphy KG, et al. Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab 2001;86(12):5992.

Druce MR, Neary NM, Small CJ, Milton J, Monteiro M, Patterson M, et al. Subcutaneous administration of ghrelin stimulates energy intake in healthy lean human volunteers. Int J Obes (Lond) 2005;30(2):293–6.

Malik S, McGlone F, Bedrossian D, Dagher A. Ghrelin modulates brain activity in areas that control appetitive behavior. Cell Metab 2008;7(5):400–9.

Brennan IM, Luscombe-Marsh ND, Seimon RV, Otto B, Horowitz M, Wishart JM, et al. Effects of fat, protein, and carbohydrate and protein load on appetite, plasma cholecystokinin, peptide YY, and ghrelin, and energy intake in lean and obese men. Am J Physiol Gastrointest liver Physiol 2012;303(1):G129–40.

Frecka JM, Mattes RD. Possible entrainment of ghrelin to habitual meal patterns in humans. Am J Physiol Gastrointest Liver Physiol 2008;294(3):G699–707.

Wren, A. M., Seal, L. J., Cohen, M. A., Brynes, A. E., Frost, G. S., Murphy, K. G., & Bloom, S. R. (2001). Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab, 86(12), 5992. Cummings DE. Ghrelin and the short-and long-term regulation of appetite and body weight. Physiol Behav 2006;89(1):71–84.

Cooper JA. Factors affecting circulating levels of peptide YY in humans: a comprehensive review. Nutr Res Rev 2014;27(1):186–97.

Pittner RA, Moore CX, Bhavsar SP, Gedulin BR, Smith PA, Jodka CM, et al. Effects of PYY[ 3–36] in rodent models of diabetes and obesity. Int J Obes 2004;28(8):963–71.

Wren AM, Bloom SR. Gut hormones and appetite control. Gastroenterology 2007;132(6):2116–30.

Batterham RL, Cohen MA, Ellis SM, Le Roux CW, Withers DJ, Frost GS, et al. Inhibition of food intake in obese subjects by peptide YY3–36. N Engl J Med 2003;349(10):941–8.

Batterham RL, Cowley MA, Small CJ, Herzog H, Cohen MA, Dakin CL, et al. Gut hormone PYY3-36 physiologically inhibits food intake. Nature 2002;418(6898):650–4.

Degen L, Oesch S, Casanova M, Graf S, Ketterer S, Drewe J, et al. Effect of peptide YY3-36 on food intake in humans. Gastroenterology 2005;129(5):1430–6.

Le Roux CW, Batterham RL, Aylwin SJ, Patterson M, Borg CM, Wynne KJ, et al. Attenuated peptide YY release in obese subjects is associated with reduced satiety. Endocrinology 2006;147(1):3–8.

Onaga T, Zabielski R, Kato S. Multiple regulation of peptide YY secretion in the digestive tract. Peptides 2002;23(2):279–90.

Batterham RL, Heffron H, Kapoor S, Chivers JE, Chandarana K, Herzog H, et al. Critical role for peptide YY in protein-mediated satiation and body-weight regulation. Cell Metab 2006;4(3):223–33.

Mars M, Stafleu A, de Graaf C. Use of satiety peptides in assessing the satiating capacity of foods. Physiol Behav 2012;105(2):483–8.

Challis B, Pinnock SB, Coll AP, Carter RN, Dickson SL, O'Rahilly S. Acute effects of PYY3-36 on food intake and hypothalamic neuropeptide expression in the mouse. Biochem Biophys Res Commun 2003;311(4):915–9.

Sloth B, Holst JJ, Flint A, Gregersen NT, Astrup A. Effects of PYY1–36 and PYY3–36 on appetite, energy intake, energy expenditure, glucose and fat metabolism in obese and lean subjects. Am J Physiol Endocrinol Metab 2007;292(4):E1062–8.

Neary NM, Small CJ, Druce MR, Park AJ, Ellis SM, Semjonous NM, et al. Peptide YY3–36 and glucagon-like peptide-17–36 inhibit food intake additively. Endocrinology 2005;146(12):5120–7.

Doucet É, Laviolette M, Imbeault P, Strychar I, Rabasa-Lhoret R, Prud'homme D. Total peptide YY is a correlate of postprandial energy expenditure but not of appetite or energy intake in healthy women. Metabolism 2008;57(10):1458–64.

Guo Y, Ma L, Enriori PJ, Koska J, Franks PW, Brookshire T, et al. Physiological evidence for the involvement of peptide YY in the regulation of energy homeostasis in humans. Obesity (Silver Spring) 2006;14(9):1562–70.

Vitaglione P, Lumaga RB, Stanzione A, Scalfi L, Fogliano V. β-Glucan-enriched bread reduces energy intake and modifies plasma ghrelin and peptide YY concentrations in the short term. Appetite 2009;53(3):338–44.

Kozimor A, Chang H, Cooper JA. Effects of dietary fatty acid composition from a high fat meal on satiety. Appetite 2013;69:39–45.

Cooper JA, Watras A, Paton CM, Wegner FM, Adams AK, Schoeller DA. Impact of exercise and dietary fatty acid composition from a high-fat diet on markers of hunger and satiety. Appetite 2011;56(1):171–8.

Heden TD, Liu Y, Sims L, Kearney ML, Whaley-Connell AT, Chockalingam A, et al. Liquid meal composition, postprandial satiety hormones, and perceived appetite and satiety in obese women during acute caloric restriction. Eur J Endocrinol 2013;168(4):593–600.

Fatima S, Gerasimidis K, Wright C, Tsiountsioura M, Arvanitidou EI, Malkova D. Response of appetite and potential appetite regulators following intake of high energy nutritional supplements. Appetite 2015;95:36–43.

Fatima S, Khan SA, Fatima F. Nutritional supplements and their use in the treatment of malnutrition in developing countries. J Ayub Med Coll Abbottabad 2015;27(4):911–22.

Zac-Varghese S, Tan T, Bloom SR. Hormonal interactions between gut and brain. Discov Med 2010;10(55):543–52.

Baranowska B, Radzikowska M, Wasilewska‐Dziubinska E, Roguski K, Borowiec M. Disturbed release of gastrointestinal peptides in anorexia nervosa and in obesity. Diabetes Obes Metab 2000;2(2):99–103.

Milewicz A, Bidzinska B, Mikulski E, Demissie M, Tworowska U. Influence of obesity and menopausal status on serum leptin, cholecystokinin, galanin and neuropeptide Y levels. Gynecol Endocrinol 2000;14(3):196–203.

Butler MG, Carlson MG, Schmidt DE, Feurer ID, Thompson T. Plasma cholecystokinin levels in Prader‐Willi syndrome and obese subjects. Am J Med Genet 2000;95(1):67–70.

Ballinger A, McLoughlin L, Medbak S, Clark M. Cholecystokinin is a satiety hormone in humans at physiological post-prandial plasma concentrations. Clin Sci (Lond) 1995;89(4):375–82.

Lieverse RJ, Jansen JB, Masclee AA, Rovati LC, Lamers CB. Effect of a low dose of intraduodenal fat on satiety in humans: studies using the type A cholecystokinin receptor antagonist loxiglumide. Gut 1994;35(4):501–5.

Brennan IM, Feltrin KL, Horowitz M, Smout AJ, Meyer JH, Wishart J, et al. Evaluation of interactions between CCK and GLP-1 in their effects on appetite, energy intake, and antropyloroduodenal motility in healthy men. Am J Physiol Regul Integr Comp Physiol 2005;288(6):R1477–85.

Brennan IM, Little TJ, Feltrin KL, Smout AJ, Wishart JM, Horowitz M, et al. Dose-dependent effects of cholecystokinin-8 on antropyloroduodenal motility, gastrointestinal hormones, appetite, and energy intake in healthy men. Am J Physiol Endocrinol Metab 2008;295(6):E1487–94.

Tai K, Feinle-Bisset C, Horowitz M, Wishart JM, Chapman IM. Effects of nutritional supplementation on the appetite and energy intake responses to IV cholecystokinin in older adults. Appetite 2010;55(3):473–7.

De Graaf C, Blom WAM, Smeets PAM, Stafleu A, Hendriks HFJ. Biomarkers of satiation and satiety. Am J Clin Nutr 2004;79(6):946–61.

Hall WL, Millward DJ, Long SJ, Morgan LM. Casein and whey exert different effects on plasma amino acid profiles, gastrointestinal hormone secretion and appetite. Br J Nutr 2003;89(2):239–48.

Pasman WJ, Blokdijk VM, Bertina FM, Hopman WP, Hendriks HF. Effect of two breakfasts, different in carbohydrate composition, on hunger and satiety and mood in healthy men. Int J Obes Relat Metab Disord 2003;27(6):663–8.

Sanggaard KM, Holst JJ, Rehfeld JF, Sandström B, Raben A, Tholstrup T. Different effects of whole milk and a fermented milk with the same fat and lactose content on gastric emptying and postprandial lipaemia, but not on glycaemic response and appetite. Br J Nutr 2004;92(3):447–59.

Zijlstra N, Mars M, de Wijk RA, Westerterp-Plantenga MS, Holst JJ, de Graaf C. Effect of viscosity on appetite and gastro-intestinal hormones. Physiol Behav 2009;97(1):68–75.

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2016-06-01

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