FREQUENCY OF METABOLIC SYNDROME IN PATIENTS WITH TYPE-2 DIABETES

Authors

  • Nasir Ahmed
  • Tauqir Ahmad
  • Syed Javed Hussain
  • Muhammad Javed

Abstract

Background: Diabetes, Hypertension, Obesity and Ischaemic Heart Disease have become a problemof public health magnitude with substantial economic burden both in the developed as well as thedeveloping countries. Obesity is quite frequent in Type 2 diabetics and also plays a central role incausing Metabolic Syndrome (MetS). Metabolic Syndrome significantly increases the incidence ofcardiovascular complications. This study was done to determine the frequency of MetS in our Type 2diabetic patients as most of the components of MetS can be modified and identifying/managing these atan early stage might be of considerable help in reducing cardiovascular complications. Methods: Thiscross-sectional study was done in Medical ‘B’ and Medical ‘A’ wards of Ayub Teaching Hospital,Abbottabad from Nov, 08 to April, 09. Type 2 Diabetic patients aged above 40 years who gaveinformed consent were included in the study. Data was collected through a structuredproforma.Frequency of Metabolic Syndrome was estimated according to the IDF consensus worldwidedefinition of the MetS. Results: Of the 100 patients enrolled in this study 56 were females and 44 weremales with a mean age of 59.9 years. Out of these 100 participants seventy six (76%) were diagnosed tohave metabolic syndrome. Of the 56 females, forty eight (85.71%) were having metabolic syndromewhile twenty eight (63.63%) of the 44 male participants were having the syndrome. The difference wasstatistically significant (p<0.05). Conclusion: Frequency of MetS was found to be significantly high inthis study with female preponderance. All the components, except Hypertension were more frequent infemales. Diabetic patients with metabolic syndrome need more aggressive approach in management soas to decrease the incidence of cardiovascular complications.Keywords: Metabolic Syndrome, Type 2 Diabetes Mellitus, Cardiovascular Complications

References

Alberti KG, Zimmet PZ. Definition, diagnosis and classification

of diabetes mellitus and its complications. Part 1; Diagnosis and

classification of diabetes mellitus; Provisional report of a WHO

consultation. Diabet Med 1998;15:539–47.

David MN, John BB, Mayer BD, Robert JH, Rury RH, Robert S,

Bernard Z. Management of Hyperglycemia in Type 2 Diabetes:

A consensus algorithm for initiation and adjustment of therapy; A

consensus statement from the American Diabetes Association

and the European Association for the Study of Diabetes.

Diabetes Care 2006;29:1963–72.

Basit A, Hydrie MZ, Hakeem R, Ahmedani MY, Masood Q.

Frequency of chronic complications of type II diabetes. J Coll

Physicians Surg Pak 2004;14:79–83

Chaudhary GM. Metabolic syndrome X in diabetic patients.

Experience in 3275 diabetic patients at Jinnah Hospital, Lahore. J

Coll Physians Surg Pak 2000;10:278–80.

Scott CL. Diagnosis, prevention and intervention for the

metabolic syndrome. Am J Cardiol 2003;92:35i–42i.

Wilson PWF, Kannel WB, Silbershatz H, D’Agostino RB.

Clustering of metabolic factors and coronary heart disease. Arch

Intern Med 1999;159:1104–9.

Khwaja AK, Rafique G, White F. Macrovascular complications

and their associated factors among persons with type 2 diabetes

in Karachi, Pakistan. J Pak Med Assoc 2004;54:60–6.

Executive Summary of the Third Report of the National

Cholesterol Education Program (NCEP), Expert Panel on

Detection, Evaluation and Treatment of High Blood Cholesterol

in Adults (Adult Treatment Panel III). JAMA 2001;285:2486–97.

Shera A, Rafique G, Khawaja I. Pakistan National Diabetes

Survey. Prevalence of glucose intolerance and associated factors

in North West Frontier Province (NWFP) of Pakistan. J Pak Med

Assoc 1999;49:206–11.

World Health Organization. Definition, diagnosis and

classification of diabetes mellitus and its complications. Report of

a WHO consultation. Part 1; Diagnosis and classification of

diabetes mellitus. Geneva: World Health Organization. 1999.

(Publ. No. WHO/NCD/NCS/00.2).

International Diabetes Federation. The IDF consensus worldwide

definition of the metabolic syndrome. Part 1: Worldwide

definition for use in clinical practice. Berlin 2005. Available at:

http://www.idf.org/webdata/docs/

IDF_Metasyndrome_definition.pdf.

Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH,

Franklin BA, et al. Diagnosis and management of the metabolic

syndrome: an American Heart Association / National Heart,

Lung and Blood Institute Scientific Statement. Circulation

;112:2735–52.

Abdul-Rahim HF, Husseini A, Bjertness E, Gordon NH, Jervell

J. The metabolic syndrome in the West Bank population: an

urban-rural comparison. Diabetes Care 2001;24:275–9.

Bruno G, Merletti F, Biggeri A, Bargreo G, Ferrero S, Runzo C,

et al. Metabolic syndrome as a predictor of all-cause and

cardiovascular mortality in type 2 diabetes: the Casale

Monferrato Study. Diabetes Care 2004;27:2689–94.

Park YW, Zhu S, Palaniappan L, Heshka S, Carnethon MR,

Heymsfield SB. The metabolic syndrome: prevalence and

associated risk factor findings in the US population from the

Third National Health and Nutrition Examination Survey, 988-

Arch Intern Med 2003;163:427–36.

Chuang SY, Chen CH, Tsai ST, Chou P. Clinical identification

of the metabolic syndrome in Kinmen. Acta Cardiol Sin

;18:16–23.

Azizi F, Salehi P, Eternadi A, Zahedi AS. Prevalence of

metabolic syndrome in an urban population; Tehran Lipid and

Glucose Study. Diabetes Res Clin Pract 2003;61:29–37.

Gupta A, Gupta R, Sarna M, Rastogi S, Gupta VP, Kothari K.

Prevalence of diabetes, impaired fasting glucose and insulin

resistance syndrome in an urban Indian population. Diabetes Res

Clin Pract 2003;61:69–76.

Park JS, Park HD, Yun JW, Jung CH, Lee WY, Kim SW.

Prevalence of the metabolic syndrome as defined by NCEP-ATP

III among the urban Korean population. Korean J Med

;63:290–8.

Isezuo SA, Ezunu E. Demographic and clinical correlates of

metabolic syndrome in Native African type 2 diabetic patients. J

Natl Med Assoc 2005;97:557–63.

Thomas GN, Ho SY, Janus ED, Lam KS, Hedly AJ, Lam TH.

The US National Cholesterol Education Programme Adult

Treatment Panel III (NCEP-ATP III) prevalence of the metabolic

syndrome in a Chinese population. Diabetes Res Clin Pract

;67:251–7.

Lee YJ, Tsai JC. ACE gene insertion/deletion polymorphism

associated with 1998 World Health Organization definition of

metabolic syndrome in a Chinese type 2 diabetic patients.

Diabetes Care 2002;25:1002–8.

Athyros VG, Bouloukos VI, Pehlivanidis AN, Dionysopoulou

SG, Symeonidis AN. The prevalence of the metabolic syndrome

in Greece: The MetS-Greece Multicentre Study. Diabetes Obes

Metab 2005;7:397–405.

Islam N. Obesity: An epidemic of 21st century. J Pak Med Ass

;55:118–22.

Lopez-Candales A. Metabolic syndrome X. A comprehensive

review of the pathophysiology and recommended therapy. J Med

;32:283–300.

Grundy SM. Obesity, metabolic syndrome and coronary

atherosclerosis. Circulation 2002;105:2696–8.

Kevin E, Oscar C Kip. Clinical importance of obesity versus the

metabolic syndrome in cardiovascular risk in women. Circulation

;109:706–13.

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Published

2010-03-01

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