LANGERHAN CELL HISTIOCYTOSIS: A CHILD PRESENTING WITH NINE MONTHS HISTORY OF FEVER
AbstractWe report a case of Langerhan Cell Histiocytosis in a three and a half years old child. The child presented with history of low grade fever, off and on for 9 months. There was 2 months history of progressive pallor and 5 days history of epistaxis. Blood complete picture revealed pancytopenia and the patient was referred to a paediatric oncologist. Initial diagnosis of acute lymphoblastic leukaemia (ALL), Lymphoma and disseminated Tuberculosis (TB) was made on basis of initial investigations. Coetaneous involvement occurred 7 months later along with Diabetes Insipidis, bone changes and pulmonary involvement.Keywords: Fever, Langerhan cell histiocytosis, lymphoma, cutaneous
Sourabh R, Hemanth IK, Sasidharan PK, Krishnan R. PUO due to Langerhans Cell Histiocytosis. J Assoc Physicians India 2005;53:479–82
Chu AC. Histiocytosis. Chapter 55 , Rooks Textbook of Dermatology.
Howarth DM, Gilchrist GS, Mullan BP, Wiseman GA, Edmonson JH, Schomberg PJ. Langerhan Cell Histiocytosis; Diagnosis, natural history, management and outcome. Cancer 1999;85:2278–90.
Arico M, Egeler RM. Clinical aspects of Langerhans cell histiocytosis. Hematol Oncol Clin North Am 1998;12(2):247–58
Gadner H, Grois N, Arico M, Broadbent V, Ceci A, Jakobson A, et al. A randomized trial of treatment for multisystem Langerhans cell histiocytosis. J Pediatr 2001;138:728–34.
Artigues Barceló A, Guiscafré Fontirroig P, de Miguel Sebastián P, Salgado RM, Albiol Varella MT. Fever and hyperprolactinaemia as the onset of Langerhans cell histiocytosis. An Med Interna 2005;22(11):535–7.
Omer NG, Aal AMA, Al-Ruqum A. Neonatal Langerhan’s Cell Histiocytosis; Early Presentation with Delayed Diagnosis Kuwait Med J 2007;39(4):355–7
Journal of Ayub Medical College, Abbottabad is an OPEN ACCESS JOURNAL which means that all content is FREELY available without charge to all users whether registered with the journal or not. The work published by J Ayub Med Coll Abbottabad is licensed and distributed under the creative commons License CC BY ND Attribution-NoDerivs. Material printed in this journal is OPEN to access, and are FREE for use in academic and research work with proper citation. J Ayub Med Coll Abbottabad accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing in J Ayub Med Coll Abbottabad. The Editorial Board of J Ayub Med Coll Abbottabad makes every effort to ensure the accuracy and authenticity of material printed in J Ayub Med Coll Abbottabad. However, conclusions and statements expressed are views of the authors and do not reflect the opinion/policy of J Ayub Med Coll Abbottabad or the Editorial Board.
USERS are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.
AUTHORS retain the rights of free downloading/unlimited e-print of full text and sharing/disseminating the article without any restriction, by any means including twitter, scholarly collaboration networks such as ResearchGate, Academia.eu, and social media sites such as Twitter, LinkedIn, Google Scholar and any other professional or academic networking site.