LINEZOLID INDUCED BLACK HAIRY TONGUE: A RARE SIDE EFFECT

Authors

  • Ishma Aijazi
  • Fadhil M Abdulla

Abstract

Linezolid induced black hairy tongue is a rare benign reversible side effect of linezolid therapy. We report a case of a 61 year old diabetic lady who developed thrombocytopenia and black hairy discoloration of the tongue after being prescribed linezolid for foot osteomyelitis by the orthopaedic surgeon. Patient was encouraged to practice good oral dental hygiene, advised to use a soft tooth brush, regular mouth wash and baking soda containing tooth paste. The condition resolved four weeks after cessation of the antibiotic therapy.Keywords: Linezolid, side effect, black tongue, oxazolidinone

References

Jover-Diaz F, Cuadrado-Paster JM, Talents-Bolos A, Martin-Gonzalez C. Black tongue associated with linezolid. Am J Ther 2010;17(4):115–7.

Amir KA, Bobba RK, Clarke B, Nagy-Agren S, Arsura EL, Balogun SA et al. Tongue discoloration in an elderly kidney transplant recipient: Treatment-related adverse event?. Am J Geriatric Pharmacother 2006;4(3):260–3.

Gerson SL, Kaplan SL, Bruss JB, Le V, Arellano FM, Hafkin B, Kuter DJ. Hematologic effects of linezolid: summary of clinical experience. Antimicrob Agents Chemother 2002;46(8):2723–6.

IIkay B,Efsan Y, Mehmet D. Black hairy tongue: a rare side effect of linezolid. Our Dermatol Online 2012; 3(2):136–7.

Ma JS. Teeth and tongue discoloration during linezolid therapy. The Pediatr Infect Dis J 2009;28(4):345–6.

Refaat M, Hyle E, Malhotra R, Seidman D, Dey B. Linezolid-induced lingua villosa nigra. Am J Med 2008;121(6):e1. doi: 10.1016/j.amjmed.2008.02.023.

Khasawneh FA, Moti DF, Zorek JA. Linezolid induced black hairy tongue: a case report. J Med Case Rep 2013;7(1):46.

Thompson DF, Kessler TL. Drug-induced black hairy tongue. Pharmacotherapy 2010;30(6):585–93.

Manabe M, Lim HW, Winzer M, Loomis CA. Architectural organization of filliform papillae in normal and black hairy tongue epithelium: dissection of differentiation pathways in a complex human epithelium according to their patterns of keratin expression. Arch Dermatol 1999;135(2):177–81.

Sarti GM, Haddy RI, Schaffer D, Kihm J. Black Hairy Tongue. Am Fam Physcian 1990;41(6):1751–5.

Published

2014-09-01

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