MALIGNANT HYPERTENSION COMPLICATED BY RENAL THROMBOTIC MICRO ANGIOPATHY: ROLE OF ADAM 13 MUTATIONAL ANALYSIS

Authors

  • Ishma Aijazi Dubai hospital Dubai Health Authority United Arab Emirates
  • Fadhil Al Shama Department of internal medicine Dubai hospital Dubai United Arab emirates
  • Lakshmiah Ganapathy Raman
  • Sara Muhtiar

Abstract

We report a case of a 38-year-old U.A.E national who presented with malignant hypertension and features of thrombotic microangiopathy. He presented with oliguria, renal failure, thrombocytopenia and haemolytic anaemia. He required several sessions of renal replacement therapy. ADAM 13 mutational analysis was sent to differentiate Thrombotic micro angiopathy due to thrombotic thrombocytopenic purpura (TTP) or malignant hypertension. Renal biopsy revealed histopathological features of malignant arteriolar nephrosclerosis (MANS). Haemolytic parameters improved after control of blood pressure and he was subsequently discharged with early nephrology follow up.Keywords: Malignant hypertension; Thrombotic Microangiopathy; MANS; Malignant arteriolar nephrosclerosis; Haemolytic uremic syndrome; HUS; Thrombotic thrombocytopenic purpura; TTP

Author Biography

Ishma Aijazi, Dubai hospital Dubai Health Authority United Arab Emirates

senior specialist registrarinternal medicine departmentDubai hospitalDubaiU.A.E

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Published

2017-06-25

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