FALCIPARUM MALARIA PRESENTING WITH TETANY: ENDOCRINOPATHIES ASSOCIATED WITH FALCIPARUM MALARIA
AbstractMalaria is a common public health problem which may have high morbidity and mortality. Physicians should be aware of the unusual presentations of this disease so that it can be timely diagnosed and treated. Herein we are presenting a case of falciparum malaria who presented to the hospital with carpopedal spasm and tetany. We will subsequently discuss mineral homeostasis and the mechanisms of hypocalcemia in falciparum malaria and the dysregulation of calcium, phosphorus and magnesium metabolism.
Irving KG, Kemp E, Olivier BJ, Mendelow BV. Unusual presentation of malaria as a leukaemoid reaction. A case report. S Afr Med J 1987;71(9):597–8.
Zaki SA, Shanbag P, Shenoy P. Unusual presentation of malaria as tetany: a case report. J Vector Borne Dis 2010;47(2):123–5.
Davis TM, Pukrittayakamee S, Woodhead JS, Holloway P, Chaivisuth B, White NJ. Calcium and phosphate metabolism in acute falciparum malaria. Clin Sci 1991;81(3):297–304.
Davis TM, Singh B, Choo KE, Ibrahim J, Sulaiman SA, Kadir ZA, et al. Dynamic assessment of parathyroid function in acute malaria. J Intern Med 1998;243(5):349–54.
Mishra S. Malaria-Precipitated Hypocalcaemia and related complications. Pharma Innov 2013;2(2, Part A):162–8.
Staines HM, Chang W, Ellory JC, Tiffert T, Kirk K, Lew V. Passive Ca2+ Transport and Ca2-dependent K+ transport in Plasmodium falciparum-infected red cells. J Membr Biol 1999;172(1):13–24.
Adini A, Krugliak M, Ginsburg H, Li L, Lavie L, Warburg A. Transglutaminase in Plasmodium parasites: activity and putative role in oocysts and blood stages. Mol Biochem Parasitol 2001;117(2):161–8.
Singh PS, Singh N. Tetany with Plasmodium falciparum infection. J Assoc Physicians India 2012;60:57–8.
Wilson M, Davis TM, Binh TQ, Long TT, Danh PT, Robertson K. Pituitary-adrenal function in uncomplicated falciparum malaria. Southeast Asian J Trop Med Public Health 2001;32(4):689–95.
Davis TM, Supanaranond W, Pukrittayakamee S, Krishna S, Hart GR, Burrin JM, et al. The pituitary-thyroid axis in severe falciparum malaria: evidence for depressed thyrotroph and thyroid gland function. Trans Royal Soc Trop Med Hyg 1990;84(3):330–5.
Prabha MR, Pereira P, Chowta N, Hegde BM. Clinical implications of hypocalcemia in malaria. Indian J Med Res 1998;108:62–5.
Journal of Ayub Medical College, Abbottabad is an OPEN ACCESS JOURNAL which means that all content is FREELY available without charge to all users whether registered with the journal or not. The work published by J Ayub Med Coll Abbottabad is licensed and distributed under the creative commons License CC BY ND Attribution-NoDerivs. Material printed in this journal is OPEN to access, and are FREE for use in academic and research work with proper citation. J Ayub Med Coll Abbottabad accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing in J Ayub Med Coll Abbottabad. The Editorial Board of J Ayub Med Coll Abbottabad makes every effort to ensure the accuracy and authenticity of material printed in J Ayub Med Coll Abbottabad. However, conclusions and statements expressed are views of the authors and do not reflect the opinion/policy of J Ayub Med Coll Abbottabad or the Editorial Board.
USERS are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.
AUTHORS retain the rights of free downloading/unlimited e-print of full text and sharing/disseminating the article without any restriction, by any means including twitter, scholarly collaboration networks such as ResearchGate, Academia.eu, and social media sites such as Twitter, LinkedIn, Google Scholar and any other professional or academic networking site.