PROTECTIVE ROLE OF GINSENG AGAINST GENTAMICIN INDUCED CHANGES IN KIDNEY OF ALBINO MICE
Abstract
Background: Use of gentamicin is now limited due to its toxic effects, mainly on kidney andvestibular system. Herbal products including ginseng has been reported to possess protective effectsagainst drugs induced nephrotoxicity in experimental animals. The current investigation wasdesigned to evaluate the effects of ginseng on gentamicin induced nephrotoxicity. Methods:Eighteen male albino mice of 6–8 weeks age, were divided into 3 groups. Group-A served as controland was given normal mouse diet; Group-B was given 80 mg/Kg/day of gentamicin intraperitoneallydissolved in 1 ml of distilled water for fifteen days. Group-C was given 80 mg/Kg/day of gentamicinintraperitoneally dissolved in 1 ml of distilled water along with 100 mg/Kg/day of ginseng orallydissolved in 1 ml of distilled water, also for fifteen days. At the end of the experiment, blood wasdrawn from each animal by cardiac puncture for renal function tests. Each animal was then sacrificedand kidneys removed for routine histological studies. Results: In group B, weight of the animals andkidneys decreased and there was significant increase in mean serum urea, creatinine andintraluminal diameter (p<0.001) of proximal convoluted tubules as compared to the controls (groupA). Moderate to severe necrotic and degenerative changes in proximal convoluted tubules were seenin this group. When the Ginseng and gentamicin were given together (group-C), a statisticallysignificant improvement in the mean body and kidney weight along with improvement in renalfunction tests and tubular diameter were seen (p<0.001). Conclusion: It appears that Ginseng hassome protective role against gentamicin induced nephrotoxicity.Keywords: Gentamicin, ginseng, nephroprotective role, nephrotoxicity, serum urea, serumcreatinineReferences
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