• Mohammad Shoaib Khan
  • Zahoor Ahmed
  • Rohila Hanif
  • Safeer Zaman
  • Irshad Ali
  • Jamil Ur Rahman
  • Fasseh -uz- Zaman


Background: Blood is man’s complete and unchangeable identity. The ABO and Rh groups arerecognised as major and clinically significant blood groups. Blood group antigens are not onlyimportant in relation to blood transfusion and organ transplantation, but also have been utilised ingenetic research, anthropology and tracing ancestral relation of humans. The objective the presentstudy is to examine the blood group antigens in infertile men for assessing the relationship to maleinfertility and to know the frequency of various blood groups among infertile males in ourpopulation. Method: A total of 1,521 patients along with 460 proven fathers as controls wererecruited for the present study from both rural and urban areas of Pakistan and referred toDepartment of Reproductive Physiology/Health, Public Health Divisions, NIH, Islamabad, during2002 to 2006. Blood grouping (ABO) and Rhesus factors (Rh) was done by the antigen antibodyagglutination test. Results: Overall distribution of blood groups in the studied population of 1,521subjects was 35.50%, 28.27%, 26.89% and 9.34% for blood groups O, B, A and AB respectively.The ratio of control to patient was 1:3.3. Conclusions: The present preliminary study revealed that inour population the prevalence of male infertility in blood group O is invariably higher than in allother ABO blood groups, showing a strong relationship between blood group O and male infertility.Keywords: Blood groups, Male infertility, Pakistani population


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