EFFECT OF RACE, GENDER AND AGE ON THYROID AND THYROID STIMULATING HORMONE LEVELS IN NORTH WEST FRONTIER PROVINCE, PAKISTAN
AbstractBackground: Thyroid is one of the ductless endocrine gland, which is located immediately belowthe larynx on either side of and anterior to the trachea. The principal hormones of thyroid glandare thyroxine (T4) and triiodothyronine (T3). The current study was carried out to investigate theimpact of race, gender and area on the levels of Thyroxine (T4), Triiodothyronine (T3) and ThyroidStimulating Hormone (TSH) in normal healthy individuals. Methods: Serum levels of T4, T3 andTSH in 498 normal healthy individuals belonging to different districts of North West FrontierProvince, Pakistan, were examined. Serum T4 and T3 were analysed by Radio Immuno Assay(RIA) method whereas TSH was estimated by Immunoradiometric assay (IRMA) method.Results: Levels of T4, T3 and TSH ranged from 53 to 167 ηmol/L, 0.6 to 3.1 ηmol/L and 0.3–4.8µIU/L respectively. The levels of these hormones show significant change from the referencevalues that are used in clinical laboratories as well as in Institute of Radiotherapy and NuclearMedicine (IRNUM), Peshawar, Pakistan. Conclusion: It is concluded that the age, gender, raceand area, all have an appreciable effect on the levels T4, T3 and TSH.Keywords: Thyroxine, Triiodothyronine, Thyroid Stimulating Hormone, TSH, Thyroid Hormones
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