• Shehla Noor
  • Ali Fawwad
  • Hasan Shahzad
  • Ruqqia Sultana
  • Rubina Bashir


Background: Preterm premature rupture of membranes is responsible for one third of all preterm birthsand is associated with significant maternal, foetal and neonatal risks. The objectives were to comparethe foeto-maternal outcome in patient with and without preterm premature rupture of membranes.Method: This prospective comparative study was conducted in Gynae-C Unit of Ayub TeachingHospital from Sep 2005 to Mar 2006. Total 170 cases were recruited in the study, out of which 85 hadPreterm Premature Rupture of Membranes (PPROM), and 85 had preterm labour without PROM.Patients’ data were recorded on a performa. Maternal outcome was measured on the basis of presenceof fever and mode of delivery. Foetal outcome was measured on the basis of weight of the baby, andpresence of infection (fever), APGAR score and neonatal death. Analysis was performed using SPSS-10. Results: The primary data arranged in groups was divided into PPROM and no-PPROM groups.The PPROM was found to be frequent in younger age group between 15–25 years while no-PPROMwas common among the age group between 26–35 years (p=0.002). Lower socioeconomic class andhistory of previous one or more preterm delivery was significantly associated with PPROM (p=0.001).Maternal fever was also significant in the PPROM group (p=0.01). Low birth weight was statisticallysignificant in the PPROM group. Majority of the babies born to mother were either extremely low birthweight or low birth weight, i.e., between 1–25 kg p-value 0.005. Low APGAR score at the time ofdelivery (p=0.01) and foetal infection (p=0.002) between the PROM and no-PPROM group was foundto be statistically significant Neo-natal deaths was also higher in the PPROM group as compared to noPPROM group (11 verses 2) (p=0.009). Conclusion: In our study premature rupture of membrane hadincreased neonatal morbidity and mortality as compared to preterm birth. Strategies should bedeveloped for its prevention.Keywords: Preterm Premature rupture of membranes, PPROM, Preterm birth


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