PERFORMANCE OF ICT-TB TEST in the Detection of Pulmonary and extra-Pulmonary TUBERCULOSIS
AbstractBackground: Tuberculosis is a major public health problem of the developing nations including Pakistan. We need a simple, economical and non invasive test to make an early diagnosis of T.B. in order to avoid the complications. Methods: A study was conducted at the Dept. of Pulmonology, PGMI LRH Peshawar & Ayub Teaching Hospital Abbottabad with the collaboration of Deptt of Pathology KMC Peshawar from Jan 1998 to Dec 2002. A total of 129 patients were included in the study. Out of these 129 patients 52 were pulmonary TB (PTB) smear positive, 30 were PTB smear negative, 30 pleural effusion & 17 were TB lymphadenitis. The control group consisted of 25 non TB patients and healthy subjects. Results: Antibody was detected in 23 of 52 (44%) sputum positive patients, 11 of 30 (36%) sputum negative PTB patients, 10 of 30 (20%) patients of TB pleural effusion and 6 of 17 (35%) patients of TB lymphadenitis. Antibody was detected in none of the control subjects. The overall sensitivity for Pul-T.B. Sputum positive patients was 44%, 36% for sputum Negative Pulmonary TB, 20% for TB pleural effusion and 35% for TB lymphadenitis. The specificity was 100%. Conclusion: ICT-TB is a highly specific, but less sensitive aid in the diagnosis of Pulmonology and extra Pulmonolgy TB.
Taelman FG, Lepage P, Schwenk A, Wenzel R. The return of tuberculosis. Diag Microbiol Infect Dis 1999;34(2):139-46.
Brown P. A disease that is alive and kicking World Health, T.B a global emergency, 46th year–1993;4:4-5.
Chang CL, Lee EY, Son HC, Park SK. Evaluating the usefulness of the ICT Tuberculosis test kit for the diagnosis of tuberculosis. J Clin Pathol 2000;53:715 –7.
Zhou AT, Ma WL, Zhang PY, Cole RA. Detection of Pulmonary & extra pulmonary Tuberculosis patients with the 38-kilo Dalton Antigen from Mycobacterium tuberculosis in a Rapid Mambrance–Based Assay. Clinical & Diagnostic Laboratory Immunology 1996;3(3):337–41.
Bothamley G, Batra H, Ramesh V. Serodiagnostic Value of the 19 Kilodalton antigen of mycobacterium tuberculosis in Indian Patients. Eur J Clin Microbiol Infect Dis 1992;11:912-5.
Wilkins EGL. Antibody detection in tuberculosis. Clinical Tuberculosis 1998;81-96.
Mathur ML, Bue PA, Catanzaro A. Evaluation of a serological test for the diagnosis of Tuberculosis. Int J Tuberc Lung Diseases 1999;3(8):732-5.
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