THE EFFECT OF LISINOPRIL ON BLOOD GLUCOSE LEVEL

Authors

  • Khalid Mahmood Qureshi
  • Raja Zafar Ahmed
  • Misbahul Islam Khan
  • Nusrat Pasha

Abstract

Khalid Mahmood Qureshi, Raja Zafar Ahmed, Misbahul Islam Khan, Nusrat PashaThe aim of this study was to evaluate the effect of lisinopril on glucose metabolism in mild to moderate hypertensivenon-insulin dependent diabetic patients. One hundred and twenty patients were divided into two groups. Group-A wasgiven placebo of lisinopril for two weeks. Group-B was given lisinopril in a fixed dose of 10 mg once daily for twoweeks. Comparison of fasting blood glucose levels before and after the treatment showed that the blood glucose levelwas almost unchanged.

References

Carlos A, FachecO, Levis C et at. Hypoglycemic

induced by angiotensin converting enzyme inhibition in

patients with non-insulin dependent diabetes mellitus

receiving sulfonylurea therapy. Am J Med 1990;

:811-2.

Gordon II. William S. Harrison’s principles of internal

medicine. Wilson, Braunwald. Issel Bacher, Petersdrof,

Martin, Fanci and Root 1991;12:1001-14.

Melvin J. Prince, Charles A et al: Metabolic effects of

hydrochlorothiazide and enalapril during treatment of

the hypertensive diabetic patients. Arch intern Med

; 148:2366-67

Shinoiri H. Veda S, Gotohe et al: Glucose and lipid

metabolism during long term linsinopril therapy in

hypertensive patients. J Cardiovac Pharmacol 1990;

(6): 905-909.

Thomas P, Hans L, Christen B: A comparison of the

effects of hydrochlorothiazide and captopril on glucose

and lipid metabolism in patients with hypertensive. N

Eng J Med 1989; 321: 868-73.

Thurig C, Bohlen L, Dshneider M et al: Insulin is

neutral to insulin sensitivity and serum lipoproteins in

essential hypertensive patients. Eur J Clin Pharmacol

; 49(1-2): 21-26.

Reaven GM, Clinking beard C, Jeppesen J et al:

Comparison of the hemodynamic and metabolic effects

of low dose hydrochlorothiazide and lisinopril

treatment in obese patients with high blood pressure.

Am J Hypertens 1995; 8:461-66.

Crepaldi G, Garraro A. Brocco E Et al. Hypertension

and non-insulin dependent diabetes. A comparison

between an angiotensin converting enzyme inhibitors

and-a calcium antagonist. Acta Diabetol 1995; 32(3):

-208.

Fogaria R. Zoppi A, Malamani GD et al. Effects of

different antihypertensive drugs on plasma fibronogen

in hypertension patients. Br J Clin Pharmacol 1995;

(5):471-7.

Downloads