THE ROLE OF SERUM AND URINARY CALCIUM LEVELS IN RENAL LITHIASIS

Authors

  • Shaheen Pervez Khan
  • Syed Shahjahan

Abstract

Serum and urinary calcium levels play a major role in the aetio-pathogenesis of renal stoneformation. In this study, serum and 24 hours’ urinary calcium of 30 healthy controls and60patients of renal lithiasis were studied. The mean age of controls and patients was 34.9(range 3-60 years) and 37.5 years (range 3 to 70 years) respectively. The male to femaleratio of controls and patients was 1.6:1 and 1.5:1 respectively. Chemical analysis of stonesshowed 42 (70.0%) were pure calcium oxalate, 2 (3.3%) pure uric acid, while the otherswere mixed stones. Calcium was found in 58 (96.7%) stones. The overall mean + SE ofserum calcium among the controls and patients was 9.43 ± 0.14 and 9.46 ± 0.15respectively, which is statistically not significant. Although the overall values of calcium ofcontrols and patients was similar, its distribution of concentration showed that 1(3.3%)control and J1 (18.3%) patients were hypercalcemic, while 4 (13.3%) controls and19(31.7%) patients were found hypercalciuric. Idiopathic hyper-calciuria was found in3(10%) of controls as compared to 8(13.3%) patients. As hypercalciuria is the morecommon laboratory finding compared to hypercalcemia among these renal stone patients,so routine screening of 24 hours’ urinary calcium is valuable in diagnosis and aetiology ofcalcium-containing renal stones.

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