FBG AND TC/HDL RATIOS IN TYPE 2 DIABETES MELLITUS

Authors

  • RUHILA HANIF
  • ABDUS SATTAR
  • IFTIKHAR QAYUM

Abstract

Background: Presence of dyslipidemia. i.e. raised Total Cholesterol (TC) and decreased High Density Lipoproteins(HDL) is an established phenomenon in type 2 diabetes mellitus. Its relationship to the fasting blood sugar (FBG)level in both diabetics and non-diabetics has yet to be established. The present study aims to show such a relationship.Methods: 150 subjects were selected and divided into two groups, one of 50 controls (non-diabetics), the other of 100patients with type 2 diabetes mellitus. Their FBG levels were determined by enzyme oxidase method, and their TCand HDL levels were determined using a standard kit method. Results: FBG and TC: HDL ratios were increased inthe patient group (p = <0.001). Comparison of FBG and TC: HDL ratios revealed a highly significant rise (p = <0.001)in the patient group. FBG with TC: HDL ratios between both groups showed a positive correlation (r = 0.554).Conclusion: The results of the present study suggest an association between FBG and TC: HDL ratios, which may bea contributory factor to the increased prevalence of coronary artery disease in patients with type 2 diabetes mellitus.

References

60th Scientific Session of the American Diabetes

Association; June I0-June 14. 2000, San Antonio Texas.

USA American / Diabetes Association Diabetes Facts

and Figures (online) available at

http://www.diabetes.org/ada/facts.asp#profile.

Accesses February 7. 2000

Mandrup-Poulsen T Diabetes BMJ 1998:316:1221-1225

(IS April)

Pyorala K, Laakso M. Uusitupa M Diabetes Metab Rev.

April 1987. Vol 3. No. 2 Diabetes and atherosclerosis an

epidemiologic view. Pages 463-524.

Kannel WB. McGee Dl. Insight from the Framingham

Study JAMA 1979.241 2035-8

Howard BV. Abbott WG. Beltz WF: Harper IT: Fields

RM.

Grundy SM. Taskinen MR Integrated study of low

density lipoprotein metabolism and very low density

lipoprotein metabolism in non-insulin-dependent

diabetes. Metabolism 1987 Sep.36(9) 870-7

Syvanne M; Taskinen MR Lipids and lipoproteins as

coronary risk factors in non-insulin-dependent diabetes

mellitus. Lancet 1997 Jul:350 Suppl LSI20-3

Turner RC. Millns H. Neil HAW. Stratton 1M. Manley

SE„ Matthews DR. et al, for the United Kingdom

Prospective Diabetes Study Group. Risk factors for

coronary artery disease in non-insulin dependent

diabetes mellitus: United Kingdom prospective diabetes

study (UKPDS: 23). BMJ 1998: 316 823-828

Editorial. Lipid modification and coronary heart disease

in type 2 diabetes: different from the general population?

Heart 1999 Jan; 81:10-1 I.

Gaster B. Hirsch IB flic Effects of Improved Glycemic

Control on Complications in Type 2 Diabetes. Arch

Intern Med 1998:158:134-140

Castelli WP. Cardiovascular diseases in women. Am .1

Obstet Gynecol 1988:158:1553 — 1560

Guyton C Female physiology before pregnancy and the

female hormones. In Textbook of Medical Physiology.

th ed. WB Saunders Co. Philadelphia 1991. 899.

Razay G. Heaton KW, Bolton CH. Coronary heart

disease risk factors in relation to the menopause.

Quarterly .1 Med 1992:889-96.

Downloads

Most read articles by the same author(s)

1 2 3 4 > >>