FBG AND TC/HDL RATIOS IN TYPE 2 DIABETES MELLITUS
AbstractBackground: Presence of dyslipidemia. i.e. raised Total Cholesterol (TC) and decreased High Density Lipoproteins(HDL) is an established phenomenon in type 2 diabetes mellitus. Its relationship to the fasting blood sugar (FBG)level in both diabetics and non-diabetics has yet to be established. The present study aims to show such a relationship.Methods: 150 subjects were selected and divided into two groups, one of 50 controls (non-diabetics), the other of 100patients with type 2 diabetes mellitus. Their FBG levels were determined by enzyme oxidase method, and their TCand HDL levels were determined using a standard kit method. Results: FBG and TC: HDL ratios were increased inthe patient group (p = <0.001). Comparison of FBG and TC: HDL ratios revealed a highly significant rise (p = <0.001)in the patient group. FBG with TC: HDL ratios between both groups showed a positive correlation (r = 0.554).Conclusion: The results of the present study suggest an association between FBG and TC: HDL ratios, which may bea contributory factor to the increased prevalence of coronary artery disease in patients with type 2 diabetes mellitus.
60th Scientific Session of the American Diabetes
Association; June I0-June 14. 2000, San Antonio Texas.
USA American / Diabetes Association Diabetes Facts
and Figures (online) available at
Accesses February 7. 2000
Mandrup-Poulsen T Diabetes BMJ 1998:316:1221-1225
Pyorala K, Laakso M. Uusitupa M Diabetes Metab Rev.
April 1987. Vol 3. No. 2 Diabetes and atherosclerosis an
epidemiologic view. Pages 463-524.
Kannel WB. McGee Dl. Insight from the Framingham
Study JAMA 1979.241 2035-8
Howard BV. Abbott WG. Beltz WF: Harper IT: Fields
Grundy SM. Taskinen MR Integrated study of low
density lipoprotein metabolism and very low density
lipoprotein metabolism in non-insulin-dependent
diabetes. Metabolism 1987 Sep.36(9) 870-7
Syvanne M; Taskinen MR Lipids and lipoproteins as
coronary risk factors in non-insulin-dependent diabetes
mellitus. Lancet 1997 Jul:350 Suppl LSI20-3
Turner RC. Millns H. Neil HAW. Stratton 1M. Manley
SE„ Matthews DR. et al, for the United Kingdom
Prospective Diabetes Study Group. Risk factors for
coronary artery disease in non-insulin dependent
diabetes mellitus: United Kingdom prospective diabetes
study (UKPDS: 23). BMJ 1998: 316 823-828
Editorial. Lipid modification and coronary heart disease
in type 2 diabetes: different from the general population?
Heart 1999 Jan; 81:10-1 I.
Gaster B. Hirsch IB flic Effects of Improved Glycemic
Control on Complications in Type 2 Diabetes. Arch
Intern Med 1998:158:134-140
Castelli WP. Cardiovascular diseases in women. Am .1
Obstet Gynecol 1988:158:1553 — 1560
Guyton C Female physiology before pregnancy and the
female hormones. In Textbook of Medical Physiology.
th ed. WB Saunders Co. Philadelphia 1991. 899.
Razay G. Heaton KW, Bolton CH. Coronary heart
disease risk factors in relation to the menopause.
Quarterly .1 Med 1992:889-96.