FBG AND TC/HDL RATIOS IN TYPE 2 DIABETES MELLITUS
Abstract
Background: Presence of dyslipidemia. i.e. raised Total Cholesterol (TC) and decreased High Density Lipoproteins(HDL) is an established phenomenon in type 2 diabetes mellitus. Its relationship to the fasting blood sugar (FBG)level in both diabetics and non-diabetics has yet to be established. The present study aims to show such a relationship.Methods: 150 subjects were selected and divided into two groups, one of 50 controls (non-diabetics), the other of 100patients with type 2 diabetes mellitus. Their FBG levels were determined by enzyme oxidase method, and their TCand HDL levels were determined using a standard kit method. Results: FBG and TC: HDL ratios were increased inthe patient group (p = <0.001). Comparison of FBG and TC: HDL ratios revealed a highly significant rise (p = <0.001)in the patient group. FBG with TC: HDL ratios between both groups showed a positive correlation (r = 0.554).Conclusion: The results of the present study suggest an association between FBG and TC: HDL ratios, which may bea contributory factor to the increased prevalence of coronary artery disease in patients with type 2 diabetes mellitus.References
60th Scientific Session of the American Diabetes
Association; June I0-June 14. 2000, San Antonio Texas.
USA American / Diabetes Association Diabetes Facts
and Figures (online) available at
http://www.diabetes.org/ada/facts.asp#profile.
Accesses February 7. 2000
Mandrup-Poulsen T Diabetes BMJ 1998:316:1221-1225
(IS April)
Pyorala K, Laakso M. Uusitupa M Diabetes Metab Rev.
April 1987. Vol 3. No. 2 Diabetes and atherosclerosis an
epidemiologic view. Pages 463-524.
Kannel WB. McGee Dl. Insight from the Framingham
Study JAMA 1979.241 2035-8
Howard BV. Abbott WG. Beltz WF: Harper IT: Fields
RM.
Grundy SM. Taskinen MR Integrated study of low
density lipoprotein metabolism and very low density
lipoprotein metabolism in non-insulin-dependent
diabetes. Metabolism 1987 Sep.36(9) 870-7
Syvanne M; Taskinen MR Lipids and lipoproteins as
coronary risk factors in non-insulin-dependent diabetes
mellitus. Lancet 1997 Jul:350 Suppl LSI20-3
Turner RC. Millns H. Neil HAW. Stratton 1M. Manley
SE„ Matthews DR. et al, for the United Kingdom
Prospective Diabetes Study Group. Risk factors for
coronary artery disease in non-insulin dependent
diabetes mellitus: United Kingdom prospective diabetes
study (UKPDS: 23). BMJ 1998: 316 823-828
Editorial. Lipid modification and coronary heart disease
in type 2 diabetes: different from the general population?
Heart 1999 Jan; 81:10-1 I.
Gaster B. Hirsch IB flic Effects of Improved Glycemic
Control on Complications in Type 2 Diabetes. Arch
Intern Med 1998:158:134-140
Castelli WP. Cardiovascular diseases in women. Am .1
Obstet Gynecol 1988:158:1553 — 1560
Guyton C Female physiology before pregnancy and the
female hormones. In Textbook of Medical Physiology.
th ed. WB Saunders Co. Philadelphia 1991. 899.
Razay G. Heaton KW, Bolton CH. Coronary heart
disease risk factors in relation to the menopause.
Quarterly .1 Med 1992:889-96.
Issue
Section
License
Journal of Ayub Medical College, Abbottabad is an OPEN ACCESS JOURNAL which means that all content is FREELY available without charge to all users whether registered with the journal or not. The work published by J Ayub Med Coll Abbottabad is licensed and distributed under the creative commons License CC BY ND Attribution-NoDerivs. Material printed in this journal is OPEN to access, and are FREE for use in academic and research work with proper citation. J Ayub Med Coll Abbottabad accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing in J Ayub Med Coll Abbottabad. The Editorial Board of J Ayub Med Coll Abbottabad makes every effort to ensure the accuracy and authenticity of material printed in J Ayub Med Coll Abbottabad. However, conclusions and statements expressed are views of the authors and do not reflect the opinion/policy of J Ayub Med Coll Abbottabad or the Editorial Board.
USERS are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.
AUTHORS retain the rights of free downloading/unlimited e-print of full text and sharing/disseminating the article without any restriction, by any means including twitter, scholarly collaboration networks such as ResearchGate, Academia.eu, and social media sites such as Twitter, LinkedIn, Google Scholar and any other professional or academic networking site.