ATHEROSCLEROSIS IN RELATION TO FAT PENNICULUS (OBESITY) BETWEEN XIPHOID AND UMBILICUS
AbstractBackground: It has been shown that possible influence of body weight is more evident forcoronary than aortic atherosclerosis; and more in men than women. Coronary heart disease due toobesity in males becomes significant when body mass index (BMI) exceeds 30 (30% overweight)and does not affect the life expectancy particularly in women. This study was conducted to assesthe relation of thickness of fat penniculus (obesity) between xiphoid and umbilicus to differentatherosclerotic lesions; and to collect basic data about age and sex distribution of this relation.Methods: It was prospective descriptive study and conducted at mortuary of King EdwardMedical University, and Department of Pathology, Allama Iqbal Medical College, Lahore. A totalof 130 human autopsies were carried out in one-and-a-half year of study duration. The ages of thedeceased ranged between 8 and 85 years. Heart aorta and its major branches were included in thisstudy. In addition, fat penniculus between xiphoid and umbilicus was measured andatherosclerosis lesions were categorised and correlated with this parameter. Haematoxylin andEosin, and different special stains were done in Pathology Department of Allama Iqbal MedicalCollege, Lahore to asses to severity of atherosclerosis lesions. Results: The fatty streaks werepresent in predominantly more cases with Fat Penniculus <20 mm than in asses with FatPenniculus <10 mm and <30 mm. The fibrolipid plaques, complicated and calcified lesions werepresent in a dominant number of cases with Fat Penniculus <30 mm on percentage basis.Conclusion: Raised lesions were seen more frequently in cases with Fat Penniculus 20 mm to <30mm than in cases with Fat Penniculus <10 mm and <20 mm thickness.Keywords: Atherosclerosis, Fat Penniculus, Lesions
Sternby NH. Atherosclerosis and body build. Bull WHO
Bradley PJ. Obesity, diet and coronary heart disease. A
dissecting view. Med J Aust 1980;I:277–8.
Nestel PJ. Obesity, diet and coronary heart disease reply.
Med J Aust 1980;1:278.
Streja DA, Boyko E, Rabkin SW. Changes in Plasma high
density lipoprotein cholesterol concentration after weight
reduction in grossly obese subjects. Br Med J 1980;281:770–2.
Noppa H. body weight change in relation to incidence of
ischaemic heart disease and change in risk factors for
ischaemic heart disease. Am J Epidemiol 1980;111:693–704.
Wilcox RG. Serum lipid concentrations and blood pressure in
obses women. Br Med J 1978:1513–5.
Sims EAH, Berchtold P. Obesity and hypertension.
Mechanisms and implications for management. JAMA 1982;
Lee IM, Manson JE, Hennekens Ch, Piffenbarger RS Jr.
Body weight and mortality: a 27- year follow-up of middleaged men. JAMA 1993;270:2823–8.
Wolk R, Berger P, Lennon R, Brilakis E,Sommers V. Body
Mass Index a risk factor for unstable angina and myocardial
infarction in patients with angiographically confirmed
coronary artery disease. Circulation 2003;108:2206–10.
Calle EE, Thun MJ, Petrelli JM, Rodreguez C, Health CW,
Body-mass index and morality in a prospective cohort of US
adult. N Engl J Med 1999;341:1097–105.
Lopez-Jumenez F, Jacobsen S, Reeder G, Weston S,
Meverden R, Roger V. Prevalence and secular trends of
excess body weight and impact on outcomes after myocardial
infarction in the community. Chest 2004;125:1205–12.
Wells B, Gentry M, Ruiz-Arango A, Dias J, Landolfo CK.
Relation between body mass index and clinical outcome in
acute Myocardial infarction, Am J Cardiol 2006; 98474–7.
Journal of Ayub Medical College, Abbottabad is an OPEN ACCESS JOURNAL which means that all content is FREELY available without charge to all users whether registered with the journal or not. The work published by J Ayub Med Coll Abbottabad is licensed and distributed under the creative commons License CC BY ND Attribution-NoDerivs. Material printed in this journal is OPEN to access, and are FREE for use in academic and research work with proper citation. J Ayub Med Coll Abbottabad accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing in J Ayub Med Coll Abbottabad. The Editorial Board of J Ayub Med Coll Abbottabad makes every effort to ensure the accuracy and authenticity of material printed in J Ayub Med Coll Abbottabad. However, conclusions and statements expressed are views of the authors and do not reflect the opinion/policy of J Ayub Med Coll Abbottabad or the Editorial Board.
USERS are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.
AUTHORS retain the rights of free downloading/unlimited e-print of full text and sharing/disseminating the article without any restriction, by any means including twitter, scholarly collaboration networks such as ResearchGate, Academia.eu, and social media sites such as Twitter, LinkedIn, Google Scholar and any other professional or academic networking site.