VARIATIONS OF SERUM SIALIC ACID LEVEL IN LIVER CIRRHOSIS
AbstractBackground: Cirrhosis liver claims many lives in our country. However early diagnosis carriesgood prognosis and prevents complications. Estimation of serum sialic acid level may be helpfulin the diagnosis of liver cirrhosis and following the dynamics of the disease especially duringtreatment and follow up to see the prognosis. Methods: Sialic acid level of 82 confirmed livercirrhosis patients of age between 18-60 years and admitted in Khyber Teaching Hospital Peshawarwas determined and compared with 40 normal controls. The patients were studied in three groupsaccording to the stage of the disease, i.e. the patients in early stages, in advancing stage, and thosein terminal stage of liver cirrhosis. Sialic acid level was determined on HPLC (Hitachi) with D-2500 chromatographer. Result: Significantly high levels of sialic acid were recorded in patients ascompared to controls. It was normal in early stage of liver cirrhosis (667±8.06nmol/ml), markedlyincreased in advancing cirrhosis (952±3.29nmol/ml) (P<0.05) and very high levels were observedin terminal stage (1058±7.50nmol/ml). Conclusion: Serum Sialic acid level was high in advancingand terminal stages of disease as compared to early stage and controls that showed normal levels.Key words: N-Acetyle Neuraminic Acid (NANA), Sialic acid of glycoproteins, Cirrhosis liver.
Martinz J, Palascak JE, Kwasniak D. Abnormal sialic acid
content of dysfibrinogenemia associated with liver disease. J
Clin Investigation 1978;61:535-8.
Oliver TK, Riidiger H, Michael P, Carolin S . Biochemical
engineering of the N-acyl side chain of Sialic acid: biological
implications. Glycobiology 2001;11(2):11-8.
Hangloo VK, Kaul I, Zargar HU. Serum Sialic acid levels in
healthy individuals. J Postgrad Med 1990;36:140-2.
Lindberg G, Iso H, Rastam L, Lundblad A, Folsom AR.
Serum Sialic Acid and its correlates in community samples
from Akita, Japan and Minnaepolis. USA. Int J Epidemiol
Okude M, Yamanaka A, Akihama S. The effects of pH on
the generation of turbidity and elasticity associated with
fibrinogen fibrin conversion by thrombin are remarkably
influenced by sialic acid in fibrinogen. Bio-pharm-Bull
Okude M, Yamanka A, Moriomoto Y, Akihama S. Sialic
acid in fibrinogen. Effects of Sialic acid on fibrinogen-fibrin
conversion by thrombin and properties of asialofibrin clot.
Biol-Pharm-Bull 1993: 16(5) : 448-52.
O’Kennedy R, Berns G, Moran E, Smyth H, Carroll K,
Thornes RD etal. A critical analysis of the use of sialic acid
determination in the diagnosis of malignancy. Cancer Lett
Matsuzaki S, Itakura M, Iwamura K, Kamiguchi H. Serum
Sialic acid levels in liver cirrhosis and liver cancer. NipponShoka-Kibyo-Gakkari-Zasshi 1981;78(12):2395-401.
Hoon DBS, Ngz Sk, Ramshaw IA. Analysis of mammary
tumour cell metastasis and release of bound N-acetyl
neuraminic acid. Br J Cancer 1985;51:775-881.
Palascak JE, Martinz J. Dysfibrinogenemia associated with
liver diseases. J-clin-Invest 1977;60(1):89-95.
Hangvoranuntakul P. Human uptake and incorporation of an
immunogenic non human dietary SA. Proc Natl Acad Sci
Narvaiza MJ, Fernandez J, Cuesta B, Paramo JA, Rocha E.
Role of Sialic acid in acquired dysfibrinogenemia associated
with liver cirrhosis. Ricerca in clinica e in laboratorio
Carlson J. α antitrypsin and other acute phase reactants in
liver-disease. Acta Med Scand 1980; 207:79.
J Ayub Med Coll Abbottabad 2005;17(3)
Kaniak J, Mejbaum KBW, Jelewska KZ, Kudreweiz HZ,
Kowal GZ. Sialic acid contents of glyproteins and
seromuciod in liver diseases. Polish Medical Journal
Luchansky SJ, Goon S, Bertozzi CR. Expanding the diversity
of unnatural cell surface S acids. Chem bioch 2004;5(3):371-
Kongtawelert P, Tangkijvanich P, ong-chi S, Poovorawan Y.
Role of SA in differentiating cholangiocarcinoma from
hepatocellular carcinoma. World Gastroenterol