• Muhammad Azhar Mughal
  • Anwar Ali Akhund


Background: This is a comprehensive report that has determined the occurrence of Myocardial infarction and Angina pectoris in"ABO" blood group system among patients with coronary artery disease in some areas of Sindh province of Pakistan. Methods:Three hundred patients with Coronary Disease (CAD) were selected from cardiology wards of LMC hospital Hyderabad, DMChospital Karachi and PMC hospital Nawabshah. The patients were separated into two categories: myocardial infarction and anginapectoris. The patients with old myocardial infarction were also included. A careful history was taken, suggesting myocardialinfarction (MI) or angina from a standard WHO (Rose) chest pain, and an electrocardiogram showing evidence of possiblemyocardial infarction and angina, and the patient's recall of a doctor's diagnosis of M.I or angina. ABO blood grouping of abovepatients was done by simple agglutination method. Results: The blood group "A" was the commonest among myocardial infarctionand angina pectoris patients while these diseases were least in blood group "O" patients. Conclusions: This comparison shows theexistence of a direct relation between blood group antigens and coronary artery disease. It is therefore of great importance for futuregenetic studies, as present report and our previous studies give clear picture of excess and deficit of CAD in particular blood groupsof "ABO" system. This may be due to some special genetic makeup


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