• Ayesha Ahmed
  • Mian Bilal Alam
  • Waheed Khan
  • Ahmed Badar
  • Syed Humayun Shah


Background: Our histopathology laboratory serves mountainous area of Hazara Division inNorthern Pakistan. This study is an analysis of the records of skin cancers reported over a nineyears period to develop local statistics about frequency and characteristics of skin cancers.Methods: Data from 1995-2003 record of cancers reported by Department of Pathology, AyubMedical College, Abbottabad were analysed to calculate cumulative and year wise frequency ofskin cancers and their major types. Frequency distribution with reference to gender and age wasalso calculated. Results: Skin cancers were 220 (1.04%) out of the total 21075 cancers recordedduring this period. Squamous cell carcinoma was diagnosed in 118 (53.6%), Basal cell carcinomain 88 (40%) and Malignant melanoma in 14 (6.4%) cases. The mean age for all skin cancersconsidered together was 58.75±15.21. Non Melanoma Skin Cancer (NMSC) were seen in all agegroups (minimum 15, maximum 103 years), while no malignant melanoma patient was under 35years of age. Gender difference in distribution was negligible with slight male preponderance(23:21). Malignant melanoma was significantly (p<0.05) more in males (71.4%), whiledistribution of both the types of NMSC was non-significantly in favour of males. We found nosignificant rise or fall in total skin cancers or any type of skin cancer in this 9 years period.Conclusions: At present the frequency of skin cancer is stable at around 1 % of total cancersreported at Ayub Medical College, reflecting a stable very low incidence rate of skin cancer inHazara Division of Pakistan.Keywords: Skin Cancer, Malignant melanoma, Non melanoma Skin Cancer, Pakistan,Histopathology


Saladi RN, Persaud AN. The causes of skin cancer: a

comprehensive review. Drugs Today (Barc) 2005;41(1):37–53.

Byrd-Miles K, Toombs EL, Peck GL. Skin cancer in

individuals of African, Asian, Latin-American, and

American-Indian descent: differences in incidence, clinical

presentation, and survival compared to Caucasians. J Drugs

Dermatol 2007;6(1):10–6.

Kopf AW, Salopek TG, Slade J, Marghoob AA, Bart RS.

Techniques of cutaneous examination for the detection of

skin cancer. Cancer 1995;75(2 Suppl):684–90.

Ch'ng S, Brougham ND, Tan ST. Pr35 the incidence of nonmelanoma skin cancer in New Zealand. ANZ J Surg 2007;77

Suppl 1:A69.

Rampen FH, Neumann HA, Kiemeney LA. Fundamentals of

skin cancer/melanoma screening campaigns. Clin Exp

Dermatol 1992;17(5):307–12.

Frentz G, Kulinsky B, Hjalgrim H, Osterlind AL. [Nonmelanoma skin cancer as a cause of death in Denmark].

Ugeskr Laeger 1991;153(8):582–4. [Article in Danish]

Trakatelli M, Ulrich C, del Marmol V, Euvard S, Stockfleth

E, Abeni D. Epidemiology of nonmelanoma skin cancer

(NMSC) in Europe: accurate and comparable data are needed

for effective public health monitoring and interventions. Br J

Dermatol 2007;156 Suppl 3:1–7.

Sanchez CF. The relationship between the ozone layer and

skin cancer. Rev Med Chil 2006;134(9):1185–90.

Aubin F, Humbey O, Guerrini JS, Mougin C, Laurent R.

[Non-melanoma skin cancers and human papillomavirus].

Ann Dermatol Venereol 2003;130(12 Pt 1):1131–8. [Article

in French]

Sanchez JA, Robinson WA. Malignant melanoma. Annu Rev

Med 1993;44:335–42.

Koh HK, Geller AC, Miller DR, Lew RA. The early

detection of and screening for melanoma. International status.

Cancer 1995;75(2 Suppl):674–83.

Ashton JF, Laura RS. Environmental factors and the etiology

of melanoma. Cancer Causes Control 1993;4(1):59–62.

Hazara Division. Wikipedia, the free encyclopaedia.

Available from

International agency for research on cancer [homepage on the

Internet]. Cancer Incidence in Five Continents Vol. IX (CI5

Vol. IX) Chapter 4: Histological groups. Available from

Gloster HM Jr, Neal K. Skin cancer in skin of color. J Am

Acad Dermatol 2006;55(5):741–60; quiz 761–4.

Beddingfield FC 3rd. The melanoma epidemic: res ipsa

loquitur. Oncologist 2003;8(5):459–65.

Coory M, Baade P, Aitken J, Smithers M, McLeod GR, Ring I.

Trends for in situ and invasive melanoma in Queensland,

Australia, 1982-2002. Cancer Causes Control 2006;17(1):21–7.

Marks R, Giles G. Trends in the incidence of nonmelanocytic skin cancer (NMSC) treated in Australia 1985-

: Are primary prevention programs starting to have an

effect? Int J Cancer 1998;78(2):144–8.

Polednak AP. Incidence of skin melanoma in Connecticut

towns and counties, 1997-2003. Conn Med 2007;71(5):275–9.

Weinstock MA. Epidemiologic investigation of

nonmelanoma skin cancer mortality: the Rhode Island

Follow-Back Study. J Invest Dermatol 1994;102(6):6S–9S.

Ishihara K. [Reasons for the increased incidence of skin

cancer]. Gan To Kagaku Ryoho. 2006 Oct;33(10):1380–5.

[Article in Japanese]

Koh D, Wang H, Lee J, Chia KS, Lee HP, Goh CL. Basal

cell carcinoma, squamous cell carcinoma and melanoma of

the skin: analysis of the Singapore Cancer Registry data

-97. Br J Dermatol 2003;148(6):1161–6.

Yasmeen N, Saeed S, Kanjee A, Sadiq S. A study of 75 cases

of Malignant Skin Tumors. J Pakistan Assoc Derma


Lewis KG, Weinstock MA. Trends in Nonmelanoma Skin

Cancer Mortality Rates in the United States, 1969 through

J Invest Dermatol 2007;127(10):2323–7.

Khan SM, Gilani J, Shagufta N. Proceedings of 1998

American Society for Clinical Oncology Annual meeting

(1998 ASCO Annual Meeting ) Breast Cancer in the region

from oxus to indus (Meeting abstract). Abstract No 581

Bhurgri Y, Bhurgri A, Pervez S, Bhurgri M, Kayani N,

Ahmed R, et al. Cancer profile of Hyderabad, Pakistan 1998-

Asian Pac J Cancer Prev 2005;6(4):474–80.

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