ROLE OF FINE NEEDLE ASPIRATION CYTOLOGY IN DIAGNOSIS OF PALPABLE BREAST LESIONS AND THEIR COMPARISON WITH HISTOPATHOLOGY
Abstract
Background: The aim of this study was to compare the diagnostic utility o fine needle aspiration cytology (FNAC) in breast lesion with gold standard of histopathological diagnosis. Methods: This descriptive cross-sectional study was conducted in Pathology department of Bannu Medical College in collaboration with Surgery Department of Khalifa Gul Nawaz Teaching Hospital Bannu as well as other private surgical hospitals of the territory. A total of 88 FNAC of palpable breast lesions were performed and compared with their corresponding histopathological reports. Patients age, location of lesion in breast, and other necessary findings were recorded on predesigned proforma, FNAC performed by using 10 ml syringes. Slides prepared and processed for cytological staining and reported by cytopathologist. Corresponding biopsies were processed for histopathological examination and diagnosis. All female patients of any age with breast lesions were included, and those breast lesions for which no histopathological report was available were excluded. Statistical Package for Social Sciences (SPSS) version 20 was used for calculation of frequencies with percentages and mean with standard deviation. Also, specificity, sensitivity, diagnostic accuracy, positive predictive value and negative predictive value were calculated by using formulas. Results: In this study the mean age was 34.44±21.57 years and age range was from 16 to 80 years. The most common age group was 26–35 years followed by 36–45 years. In this study sensitivity was (83.33%), specificity was (100 %), positive predictive value was (100 %), negative predictive value was (99.27%) and diagnostic accuracy was 99.30%. Conclusion: FNAC breast is an easily approachable, less invasive, cheap, rapid and almost accurate diagnostic tool in the diagnosis of palpable as well as non palpable breast lesions.Keywords: FNAC; Breast lesions; Mastitis; Fibroadenoma; Invasive ductal carcinomaReferences
Orell SR, Sterrett GF, Walters MN-I, Whitaker D. Manual and Atlas of Fine Needle Aspiration Cytology. 3rd ed. London, England: Churchill Livingstone, 1999.
Qureshi H, Amanullah A, Khan KM, Deeba F. Efficacy of fine needle aspiration cytology in the diagnosis of breast lumps. J Postgrd Med Inst 2011;21(4):301–4.
Saleh FM, Ansari NP, Alam O. Comparison between fine needle aspiration cytology with histopathology to validate accurate diagnosis of palpable breast lump. Mymensingh Med J 2012;21(3):450–5.
Shrestha A, Chalise S, Karki S, Shakya G. Fine needle aspiration cytology in a palpable breast lesion. J Pathol Nepal 2011;1(2):131–5.
Bajwa R, Zulfiqar T. Association of fine needle aspiration cytology with tumor size in Palpable breast lesions. Biomedica 2010;26:124–9.
Jamal AA, Mansoor I. Analysis of false positive and false negative cytological diagnosis of breast lesions. Saudi Med J 2001;22(1):67–71.
Abulkhair OA, Al Tahan FM, Young SE, Musaad SM, Jazieh AR. The first national public breast cancer screening program in Saudi Arabia. Ann Saudi Med 2010;30(5):350–7.
Rahman S, Ali M, Khalili Y, Ali A, Lal A. Role of fine needle asporation cytology in evaluating the breast lumps. Gomal J Med Sci 2011;9(1):59–61.
Koirala S. Comparative study of aspiration and non-aspiration cytology of Palpable breast lumps and correlation with histopathology. J Pathol Nepal 2014;4(8):639–43.
Homesh NA, Issa MA, El-Sofiani HA. Diagnostic Accuracy of Fine Needle Aspiration Cytology in Palpable Breast Lump(s). Saudi Med J 2005;26(1):42–6.
Sawan SA, Mufti ST. Comparative Study between Breast Cytology and Histology in Saudi Females. J King Abdulaziz Univ Med Sci 2011;18(281):1–38.
Khan A, Jamali R, Jan M, Tasneem M. Correlation of Fine Needle Aspiration Cytology and Histopathology Diagnosis in the Evaluation of Breast Lumps. Int J Med Stud 2014;2(2):40–3.
Rathi M, Khalid M, Budania SK, Mittal A, Verma N. A clinicopathologic study of various breast lesions with cytohistological correlation. Muller J Med Sci Res 2015;6(1):16–22.
Vasavada AD, Kher S. Cytohistological correlation of palpable breast mass: A study of 300 cases. Ann Pathol Lab Med 2017;4(6):A632–7.
Pandey V, Verma NK, Sudharshan V, Chandrakar KS, Sharma A. Cyto-histopathological correlation of breast lesions- A rural hospital based study. Indian J Pathol Oncol 2017;4(1):117–21.
Daramola AO, Odubanju MO, Obiajulu FJ, Ikeri NZ, Banjo AAF. Correlation between fine needle aspiration cytology and histology for palpable breast masses in a Nigerian Tretiary Health Institution. Int J Breast Cancer 2015;2015:742573.
Chauhan N, Pathak VP, Harsh M, Saini S, Gaur DS. Cytohistopathological correlation of palpable breast lesions. Indian Med Gaz 2012;473–8.
Srilakshmi HP, Chavda J. Study of cyto-histological correlation of breast lesions. NJIRM 2013;4(2):54–6.
Mehra K, Kumar V, Kaur R, Gupta N. Cyto-histopathological correlation in palpable breast lesions. Int J Res Med Sci 2016;4(6):1943–49.
Paramesh As, Kariappa TM. Correlation of fine needle aspiration cytology and histopathology in palpable breast lesions in 100 patients of KVG Medical College & Hospital, Sullia, Karnataka. Int J Appl Res 2015;1(8):422–27.
Bukhari MH, Arshad M, Jamal S, Niazi S, Bashir S, Bakhshi IM, et al. Use of Fine-Needle Aspiration in the Evaluation of Breast Lumps. Pathol Res Int 2011;2011:689521.
Published
Issue
Section
License
Journal of Ayub Medical College, Abbottabad is an OPEN ACCESS JOURNAL which means that all content is FREELY available without charge to all users whether registered with the journal or not. The work published by J Ayub Med Coll Abbottabad is licensed and distributed under the creative commons License CC BY ND Attribution-NoDerivs. Material printed in this journal is OPEN to access, and are FREE for use in academic and research work with proper citation. J Ayub Med Coll Abbottabad accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing in J Ayub Med Coll Abbottabad. The Editorial Board of J Ayub Med Coll Abbottabad makes every effort to ensure the accuracy and authenticity of material printed in J Ayub Med Coll Abbottabad. However, conclusions and statements expressed are views of the authors and do not reflect the opinion/policy of J Ayub Med Coll Abbottabad or the Editorial Board.
USERS are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.
AUTHORS retain the rights of free downloading/unlimited e-print of full text and sharing/disseminating the article without any restriction, by any means including twitter, scholarly collaboration networks such as ResearchGate, Academia.eu, and social media sites such as Twitter, LinkedIn, Google Scholar and any other professional or academic networking site.
