SECONDARY PLASMA CELL LEUKAEMIA
AbstractPlasma cell leukaemia is a clinical condition in which plasma cells circulating in the peripheral blood constitute > 20% of white blood cells (WBC) and there is evidence of plasma cell monoclonality. It is important to be diagnosed early for better treatment outcome. Although it is a rare disease, cases have been reported from Pakistan and other countries (including our neighbouring countries), hence making this case report. After taking history of present and past ailments, physical examination was carried out. Blood and bone marrow sampling were done after taking informed written consent from the patient. Blood samples were obtained in plain bottle, anticoagulated bottle and bone marrow was obtained from posterior iliac spine under 2% lignocaine. Plasma cell leukaemia is a rare and aggressive disease, difficult to diagnose and treat, requires early recognition and therapeutic intervention.Keywords: Plasma cell leukaemia; Multiple myeloma; Monoclonal gammopathy; Plasma cell myeloma; Solitary plasmacytoma
Kyle RA, Maldonado JE, Bayrd ED. Plasma cell leukemia. Report on 17 cases. Arch Intern Med 1974;133(5):813–18.
Jiménez-Zepeda VH, Domínguez VJ. Plasma cell leukemia: a rare condition. Ann Hematol 2006;85(5):263–7.
Bladé J, Kyle RA. Non-secretary myeloma, immunoglobulin D myeloma, and plasma cell leukemia. Hematol Oncol Clin 1999;13(6):1259–72.
Sher T, Miller KC, Deeb G, Lee K, Chanan-Khan A. Plasma cell leukaemia and other aggressive plasma cell malignancies. Br J Haematol 2010;150(4):418–27.
Tiedemann RE, Gonzalez-Pazet N, Kyle RA, Santana-Davila R, Price-Troska T, Ven Wier SA, et al. Genetic aberrations and survival in plasma cell leukemia. Leukemia 2008;22(5):1044–52.
International Myeloma Working Group. Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group. Br J Haematol 2003;121(5):749–57.
Jameel A. Plasma cell leukemia: case report of a rare and aggressive variant of multiple myeloma. J Pak Med Assoc 2005;55(10):452–53.
Sajid R, Moiz B, Kamran N, Adil SN. Pleural fluid plasmacytosis in a patient with plasma cell leukemia. Turk J Hematol 2010;27(2):135–36.
Humayun M, Khan A, Haider I, Muhammad W, Ajmal F, Jehanzeb. Plasma cell leukemia (pcl), a rare and aggressive variant of multiple myeloma (MM). Med Res Chron 2015;2(1):121–5.
Mehdi SR, Tiwari K, Jaiswal A, Usmani RZ, Tripathi T. Primary Plasma Cell Leukemia- A Rare Case Report. Int J Med Sci Clin Invent 2018;5(6):3879–80.
Fernández de Larrea C, Kyle RA, Durie BG, Ludwig H, Usmani S, Vesole DH, et al. Plasma cell leukemia: consensus statement on diagnostic requirements, response criteria and treatment recommendations by the International Myeloma Working Group. Leukemia 2013;27(4):780–91.
Journal of Ayub Medical College, Abbottabad is an OPEN ACCESS JOURNAL which means that all content is FREELY available without charge to all users whether registered with the journal or not. The work published by J Ayub Med Coll Abbottabad is licensed and distributed under the creative commons License CC BY ND Attribution-NoDerivs. Material printed in this journal is OPEN to access, and are FREE for use in academic and research work with proper citation. J Ayub Med Coll Abbottabad accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing in J Ayub Med Coll Abbottabad. The Editorial Board of J Ayub Med Coll Abbottabad makes every effort to ensure the accuracy and authenticity of material printed in J Ayub Med Coll Abbottabad. However, conclusions and statements expressed are views of the authors and do not reflect the opinion/policy of J Ayub Med Coll Abbottabad or the Editorial Board.
USERS are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.
AUTHORS retain the rights of free downloading/unlimited e-print of full text and sharing/disseminating the article without any restriction, by any means including twitter, scholarly collaboration networks such as ResearchGate, Academia.eu, and social media sites such as Twitter, LinkedIn, Google Scholar and any other professional or academic networking site.