SECONDARY PLASMA CELL LEUKAEMIA
AbstractPlasma cell leukaemia is a clinical condition in which plasma cells circulating in the peripheral blood constitute > 20% of white blood cells (WBC) and there is evidence of plasma cell monoclonality. It is important to be diagnosed early for better treatment outcome. Although it is a rare disease, cases have been reported from Pakistan and other countries (including our neighbouring countries), hence making this case report. After taking history of present and past ailments, physical examination was carried out. Blood and bone marrow sampling were done after taking informed written consent from the patient. Blood samples were obtained in plain bottle, anticoagulated bottle and bone marrow was obtained from posterior iliac spine under 2% lignocaine. Plasma cell leukaemia is a rare and aggressive disease, difficult to diagnose and treat, requires early recognition and therapeutic intervention.Keywords: Plasma cell leukaemia; Multiple myeloma; Monoclonal gammopathy; Plasma cell myeloma; Solitary plasmacytoma
Kyle RA, Maldonado JE, Bayrd ED. Plasma cell leukemia. Report on 17 cases. Arch Intern Med 1974;133(5):813–18.
Jiménez-Zepeda VH, Domínguez VJ. Plasma cell leukemia: a rare condition. Ann Hematol 2006;85(5):263–7.
Bladé J, Kyle RA. Non-secretary myeloma, immunoglobulin D myeloma, and plasma cell leukemia. Hematol Oncol Clin 1999;13(6):1259–72.
Sher T, Miller KC, Deeb G, Lee K, Chanan-Khan A. Plasma cell leukaemia and other aggressive plasma cell malignancies. Br J Haematol 2010;150(4):418–27.
Tiedemann RE, Gonzalez-Pazet N, Kyle RA, Santana-Davila R, Price-Troska T, Ven Wier SA, et al. Genetic aberrations and survival in plasma cell leukemia. Leukemia 2008;22(5):1044–52.
International Myeloma Working Group. Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group. Br J Haematol 2003;121(5):749–57.
Jameel A. Plasma cell leukemia: case report of a rare and aggressive variant of multiple myeloma. J Pak Med Assoc 2005;55(10):452–53.
Sajid R, Moiz B, Kamran N, Adil SN. Pleural fluid plasmacytosis in a patient with plasma cell leukemia. Turk J Hematol 2010;27(2):135–36.
Humayun M, Khan A, Haider I, Muhammad W, Ajmal F, Jehanzeb. Plasma cell leukemia (pcl), a rare and aggressive variant of multiple myeloma (MM). Med Res Chron 2015;2(1):121–5.
Mehdi SR, Tiwari K, Jaiswal A, Usmani RZ, Tripathi T. Primary Plasma Cell Leukemia- A Rare Case Report. Int J Med Sci Clin Invent 2018;5(6):3879–80.
Fernández de Larrea C, Kyle RA, Durie BG, Ludwig H, Usmani S, Vesole DH, et al. Plasma cell leukemia: consensus statement on diagnostic requirements, response criteria and treatment recommendations by the International Myeloma Working Group. Leukemia 2013;27(4):780–91.