• Najamul Haq
  • Basharat Ali Khan
  • Muhammad Imran
  • Adeel Akram
  • Abdul Basit Jamal
  • Fatima Bangash


Background: Gallbladder carcinoma is a relatively uncommon neoplasm which is more common in the seventh decade of life compared to that of cholelithiasis which is in the fourth decade. The objective of the study was to determine the frequency of carcinoma gall bladder in cases of acute and chronic cholecystitis particularly with reference to cholelithiasis. Methods: This cross-sectional observational study was done in the department of Surgery at Fauji Foundation Hospital, Rawalpindi from 1stJanuary, 2009 till 31stOctober, 2011. All 310 cholecystectomies performed during this period were included in this study. The specimens collected were macroscopically examined and sent for histopathology. All the reports were reviewed and the results recorded. Results: Out of 310 cases, 27 (8.7%) had acute cholecystitis and 280 (91.2%) were chronic cholecystitis. 3 specimens got autolysed and therefore excluded from the study. 290 cases had cholelithiasis. 2 out of 290 calculous cases were found to have coexistent carcinoma gall bladder proven on histopathology. Conclusion: Frequency of carcinoma gallbladder associated with cholelithiasis discovered incidentally after cholecystectomy is very low in our patients.Keywords: Cholelithiasis, carcinoma gallbladder, histopathology, cholecystitis


Wasim B, Kafil N, Hadi NI, Afshan G. Age and gender related frequency of cancer in chronic cholelithiasis, J SurgPak2010;15(1):48–51.

Naqvi SQH, Mangi IH, Dahri FJ, Khaskheli QA, Ali A. Akhund A. Frequency of carcinoma of gallbladder in patients with cholelithiasis. Gomal J Med Sci 2005;3:41–3.

Russel RCG. The gallbladder and bile ducts. In: Russel RCG, Williams NS, Bulstrode CJK, editors. Bailey and Love’s short practice of surgery. 24th ed. London: Hodder Arnold;2004.p. 1094–1113.

Kubicka S. Cholangiocellular and gallbladder carcinoma. Z Gastroentrol2004;42:397–402.

Ahmed I. Prevalence of Carcinoma Gallbladder inpatients with Cholelithiasis. Pak J Med Sci 1995;11:213–7.

Fukuda K, Kuroki T, Tajima Y, Tsuneoka N, Kitajima T, Matsuzaki S, et al. Comparative analysis of Helicobacter DNAs and biliary pathology in patients with and without hepatobiliary cancer. Carcinogenesis. 2002;23:1927–31.

Pandey M, Pathak AK, Gautam A, Aryya NC, Shukla VK. Carcinoma of the gall bladder. A retrospective review of 99 cases. Dig Dis Sci2001;46:1145–51.

Moosa FA, Sultan N, Ahmed S, Hafeiz M. Incidence of carcinoma of gallbladder discovered on routine histopathology after cholecystectomy for cholelithiasis. Med Channel 2002;8:15–7.

Shaikh SM, Shaikh IA, Mughal SI. Incidence of gall bladder malignancy in patients with cholelithiasis. J Surg Pak 1999;4:18–21.

Ahmed G. Carcinoma Gallbladder; Incidence in Cholelithiasis. The Professional 1998;5:437–44.

Yalsin S. Carcinoma of the gallbladder. orphaned encyclopaedia; November 2004. Available at:

Hayes PC, Simpson KJ, Garden OJ. Liver and biliary tract disease. In: Davidson's Principles and Practice of Medicine. 19th ed. Edinburgh: Churchill Livingstone; 2002:831–88



Most read articles by the same author(s)

1 2 > >>