CLINICAL PRESENTATIONS IN IMMUNE THROMBOCYTOPENIC PURPURA

Authors

  • Jamila Farid
  • Nasreen Gul
  • Waqar -Ur-Rehman Qureshi
  • Muhammad Idris

Abstract

Background: Thrombocytopenia is an important cause of mucocutanaeous bleeding in adult andpaediatric patients. Immune thrombocytopenia is one of the common causes of thrombocytopenia. Itsclinical presentations vary from patient to patient, not studied in our area previously. The presentstudy was planned to see the frequency of clinical presentations of Immune ThrombocytopenicPurpura (ITP) in our patients. Methods: This prospective study was conducted on 125 patients withITP, diagnosed by exclusion of secondary causes of thrombocytopenia. Bone marrow examinationwas performed on all the patients. Results: Bruising, epistaxis and gum bleeding were thecommonest clinical presentations in adults and children. Bleeding was more severe in acute cases.Increased menstrual bleeding was seen in female patients. Conclusion: Bruising, epistaxis and gumbleeding are the commonest clinical presentations of ITP. Our results are not much different fromthose of the other studies conducted in Pakistan.Keywords: Thrombocytopenia, Immune thrombocytopenic purpura, mucocutanaeous bleeding

References

Cines DB, Blanchette VS. Immune thrombocytopenic purpura.

New Engl J Med 2002;346:995–1008.

George JN. Diagnosis, clinical course, and management of

idiopathic thrombocytopenic purpura. Curr Opin Hematol

;3:335–40.

Kuhne T. Idiopathic thrombocytopenic purpura in childhood:

controversies and solutions. Pediatr Blood Cancer

;47(S5):650–2.

McMillan R. Therapy for adults with refractory chronic

immune thrombocytopenic purpura. Ann Intern Med

;126(4):307–14.

Segal J, Powe N. Prevalence of immune thrombocytopenia:

analyses of administrative data. J Thromb Haemost

;4:2377–83.

Muhsen AA, Abdurrahman KN. Bone marrow examination in

isolated childhood thrombocytopenia. Pak Paed J

;35(4):209–12.

Ahmad Z, Naveedur Durrani NR, Hazir T. Bone marrow

examination in ITP in children: is it mandatory? J Coll

Physicians Surg Pak 2007;17:347–9.

Aziz M, Nazar N, Ahmad R, Mazari N, Farooq H, Khan SW,

et al. Clinico hematologic features of immune

thrombocytopenic purpura and its association with autoimmune

disorders. Biomedica 2009;25(1):14–8.

Rehman Z, Alam M, Mubarik A, Ahmed M. Clinical Spectrum

of Thrombocytopenia in Adult Population of Karachi. J Coll

Physicians Surg Pak 2001;11:603–5.

Mohammad J, Rahim F, Nayyar J. Frequency of clinical

features of IdiopathicThrombocytopenic Purpura. J Med Sci

;19 (3):126–8.

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Published

2012-06-01

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