SEROPREVALENCE OF HEPATITIS B IN OUTDOOR FEMALE PATIENTS OF REPRODUCTIVE AGE GROUP AT AYUB TEACHING HOSPITAL ABBOTTABAD

Authors

  • Jamila Farid
  • Taher Salim
  • Javed Sarwar
  • Muhammad Idris
  • Nasreen Gul
  • Syed Humayun Shah
  • Muhammad Suleman

Abstract

Background: Hepatitis B is inflammation of the liver caused by a Hepatitis B virus, having aparenteral mode of entry and infecting millions of people around the world. Objective: Thepresent study was planned to assess the seroprevalence of Hepatitis B in women of reproductiveage in Hazara in order to promote disease prevention in the perinatal period by vaccination againstHepatitis B. Subjects and Methods: Women 15–45 years old belonging to Hazara Division wereincluded in this descriptive, cross-sectional study conducted over a period of one year at theDepartment of Microbiology, Ayub Medical College, Abbottabad in collaboration with theDepartment of Pathology, Ayub Teaching Hospital, Abbottabad from 1st March 2006 to 28thFebruary 2007. Non-probability convenience sampling was done to select 500 females from thosevisiting Ayub Teaching Hospital Abbottabad as outdoor patients or accompanying person.History, examination, and serum alanine aminotransferase estimation were followed by the initialscreening for Hepatitis B surface Antigen (HBsAg) using immunochromatographic device.Enzyme linked Immunosorbent assay was used to confirm the presence of HBsAg. Results:HBsAg was detected in 3% of the women. History of multiple injections was present in 100%,blood transfusion in 22%, dental procedure in 46% and surgical procedure in 43% of the subjects.Only 1% women had been vaccinated. Conclusion: Seroprevalence of the Hepatitis B is notdifferent from the figures reported by the studies previously conducted on general population inPakistan. However it is different from those reported for the special groups.Keywords. Hepatitis B, Viral Hepatitis, Chronic liver disease, HBsAg, immunochromatographicdevice, ELISA

References

Lin HJ, Lai CL, Lau JYN. Evidence of intrafamilial transmission

of hepatitis B virus from sequence analysis of mutant hepatitis B

viral DNAs in Chinese families. Lancet 1990;336:208–12.

Wong VC, Ip HM, Reesink HW, Lelie PN, Reerink-Brongers

EE, Yeung CY. Prevention of the HBsAg carrier state in

newborn infants of mothers who are chronic carriers of HBsAg

and HBeAg by administration of hepatitis-B vaccine and

hepatitis-B immunoglobulin. Double blind randomised placebocontrolled study. Lancet 1984;1:921–6.

Hollinger FB, Liang TJ. Hepatitis B virus. In: Knipe DM,

Howley PM, eds. Fields virology. 4th ed. Vol. 2. Philadelphia:

Lippincott Williams & Wilkins, 2001:2971–3036.

Norder H, Courouce AM, Magnius LO. Complete genomes,

phylogenetic relatedness and structural proteins of six strains of

the hepatitis B virus, four of which represent two new genotypes.

Virology1994;198:489–503.

McMahon BJ. Epidemiology and natural history of hepatitis B.

Semin Liver Dis 2005;25(Suppl 1):3–8.

Ali N, Khattak J, Anwar M, Tariq W, Nadeem M, Irfan M, et

al. Prevalence of hepatitis B surface antigen and hepatitis C

antibodies in young healthy adults. Pakistan J Pathol

;13:3–6.

Majed A, Qayyum A. Presence of hepatitis-B virus in healthy

donors at blood unit Punjab Institute of Cardiology Lahore.

Pakistan J Med Res 2000;39:111–2.

Rana G, Akmal N, Akhtar N. Prevalence of hepatitis B in

pregnant females Ann King Edward Med Coll 2006;12:313.

Mirza IA, Mirza SH, Irfan S, Siddiqi R, Tariq W, Janjua AN.

Seroprevalence of Hepatitis B and C in young adults seeking

recruitment in armed forces. Pak Armed Forces Med J

;56:192–7.

Bond WW, Favero MS, Petersen, NJ, Gravelle CR, Ebert JW,

Maynard JE. Survival of hepatitis B virus after drying and

storage for one week. Lancet 1981;1:550–1.

Nakano NI, Eto A, Chikaura Y, Oishi T. Multienzyme control

serum (Sera Clear-HE) containing human enzymes from

established cell lines and other sources. 2: Evaluation as

candidate working enzyme reference material for Alanine and

aspartate aminotransferases. J Clin Chem Clin Biochem

;24:497–510.

Sato L, Khiyama S, Linnuma Y, Nada T, Shimokata K,

Nakashima N. Evaluation of immunochromatographic assay

systems for rapid detection of hepatitis B surface antigen and

antibody. J Clin Microbiol 1996;34(6):1420–2.

Yousfani S, Mumtaz F, Memon A, Memon MA, Sikandar R.

Antenatal screening for Hepatitis B and C virus carrier state at a

University Hospital. J Liaquat Uni Med Health Sci

;5(10):24–7.

Khan HI. A study of seroprevalence of Hepatitis B and C in

Mothers and children in Lahore. Pakistan Ped J

;20(4):163–6.

Kazmi K, Ghafoor A, Qureshi AW. Mother-infant transmission

of Hepatitis B in Pakistan. Pakistan J Med Res 2003;42(4):1526.

Mehnaz A, Hashmi H, Syed S, Kulsoom. Hepatitis B markers in

mothers and its transmission in newborn. J Coll Physician Surg

Pak 2002;12(4):240–47.

Khokhar N, Gill ML, Malik GJ. General Seroprevalence of

Hepatitis C and Hepatitis B virus infections in population. J Coll

Physician Surg Pak 2004;14(9):534–6.

Zakaria M, Ali S, Tariq GR, Nadeem M. Prevalence of

Antihepatitis C antibodies and Hepatitis B Surface Antigen in

healthy male Naval recruits. Pak Armed Forces Med J

;53(1):3–5.

Qasmi SA, Aqeel S, Ahmed M, Alam SI, Ahmed A. Detection of

Hepatitis B viruses in Normal Individuals of Karachi. J Coll

Physician Surg Pak 2000;10(2):467–9.

Marri SM, Ahmed J. Prevalence of Hepatitis B antigenemia in

general population of Quetta, Baluchistan. Biomedica

;13(2):51–2.

Khan MA, Ali AS, Hassan ZU, Mir F, Haque SU.

Seroprevalence of Hepatitis B in children Pakistan Ped J

;22:75–7.

Farooq MA, Iqbal MA, Tariq W, Hussain AB, Ghani I.

Prevalence of Hepatitis B and C in a healthy cohort. Pakistan J

Pathol 2005;16(2):42–6.

Abbas Z, Shazi L, Jafri W. Prevalence of Hepatitis B in

individuals screened during a countrywide vaccination compaign.

J Coll Physicians Surg Pak 2006;16:495.

Talpur AH, Ansari HG, Awan MS, Ghumro AA. Prevalence of

Hepatitis B and C in surgical patients. Pak J Surg

;22(3):150–3.

Chaudhary I.A, Khan SA, Samiullah. Should we do Hepatitis B

and C screening on each patient before surgery: analysis of 142

cases. Pak J Med Sci 2005;21(3):278–80.

Masood Z, Jawaid M, Khan RA, Rehman S. Screening for

Hepatitis B and C: A routine preoperative investigation? Pak J

Med Sci 2005;21(4):455–9.

Ashraf, MN, Hussain T. Prevalence of Hepatitis B and C in

diabetics. Pakistan J Pathol 2004;15(3):113–5.

Khitab U, Khan SA, Shah SA, Haq N. Hepatitis in dental

practice–A study conducted on 1498 patients. Pak Oral Dental J

;25(1):25–9.

Shrestha SK, Bhattarai MD. Study of Hepatitis B among

different categories of health care workers. J Coll Physicians

Surg Pak 2006;16(2):108–11.

Mohammad J, Hussain M, Khan MA. Frequency of Hepatitis B

and Hepatitis C infection in thalassaemic children. Pakistan Ped J

;13(4):3–6.

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Published

2009-12-01

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