• Farhat Naz
  • Saqib Malik
  • Tariq Mehmood
  • Sumbal Tariq


Background: Viral encephalitis is a common condition but only a few studies are available onoccurrence of viral encephalitis in postnatal women. The objective of this study was to determine thefrequency of postnatal encephalitis among patients presenting with cerebral neurological complicationsduring puerperium and to determine a response to 10 day course of acyclovir therapy and final outcomeof the patients. Methods: This cross-sectional descriptive study was conducted at Department ofMedicine, Unit A, Ayub Teaching Hospital, Abbottabad from Jan to Dec 2011. All patients presentingwith encephalitis in their postnatal period were enrolled. Eclampsia patients were excluded from study.The diagnosis of encephalitis was made on clinical assessment, CSF routine examination, CT scan andMRI. Results: Among patients 16 (84.2%) presented with fever, 13 (68.42%) with headache, 8(42.1%) with meningeal irritation, 7 (36.84%) with hemiparesis, 18 (94.7%) with altered sensorium, 13(68.42%) with seizures, and 7 (36.84%) with coma. Cerebrospinal fluid of 16 (84.21%) patient had thechanges consistent with viral encephalitis. It was normal in 2 (10.52%) patients and showed picture ofpyogenic meningitis in 1 (5.26%) cases. On CT scan of brain, 3 (15.78%) had normal scans, 3(15.78%) had cerebral oedema, 4 (21.05%) had ischemic infarct, 3 (15.78%) had meningo-encephalitis,2 (10.52%) had infarct plus cerebral oedema, 1 (5.26%) had encephalitis and 3 (15.78%) had infarctplus haemorrhage. On MRI brain 15 out of 17 (88.2%) had lesions consistent with encephalitis. All 19(100%) patients were treated with 10 days course of acyclovir and a broad spectrum third generationantibiotic. After hospitalisation 11 (57.8%) patients were discharged with complete recovery, 5(26.31%) were discharged with partial recovery and 3 (15.78%) patients expired. Conclusion: Clinicalpresentation of the patient is most important in diagnosing viral encephalitis in postnatal womenespecially when patient presents with fever, altered sensorium and convulsions. Acyclovir therapyshould be started without delay while awaiting other investigations.Keywords: Encephalitis, postnatal, acyclovir


Gupta S, Rohatgi A, Sharma SK, Gurtoo A. A study of

neurological disorders during pregnancy and puerperium. Ann

Indian Acad Neurol 2006;9(3):152–7.

Czupryna P, Moniuszko A, Adamczyk-Przychodzeñ A,

Pancewicz SA, Kondrusik M, Zajkowska J. Viral encephalitis in

puerperium period –case report. Pol Merkur Lekarski


Dutta A, Tonkin T, Gelman W. Postpartum convulsions –a

diagnostic enigma. J R Soc Med 2006;99(4):203–4.

Sauerbrei A, Wutzler P. Herpes simplex and varicella-zoster

virus infections during pregnancy: current concepts of

prevention, diagnosis and therapy. Part 1: Herpes simplex virus

infections. Med Microbiol Immunol 2007;196(2):89–94.

Pauranik A, Jain S, Maheshwari MC. Herpes simplex virus

type-2 encephalitis in peripartum period preceded by hepatitis.

Jpn J Med 1987;26:84–7.

Whitley RJ. Herpes simplex encephalitis: adolescents and

adults. Antiviral Res 2006;71(2–3):141–8.

Raschilas F, Wolff M, Delatour F. Outcome of and prognostic

factors for herpes simplex virus encephalitis in adults: results of

a multicenter study. Clin Infect Dis 2002;35:254–60.

Utley TF, Ogden JA, Gibb A, McGrath N, Anderson NE. The

long-term neuropsychological outcome of herpes simplex

encephalitis in a series of unselected survivors.

Neuropsychiatry Neuropsychol Behav Neurol 1997;10:180–9.

Brown ZA, Selke S, Zeh J, Kopelman J, Maslow A, Ashley RL,

et al. The acquisition of herpes simplex during pregnancy. N

Engl J Med 1997;337:509–15.

McGrath N, Anderson NE, Croxson MC, Powell KF. Herpes

simplex encephalitis treated with acyclovir: diagnosis and long

term outcome. J Neurol Neurosurg Psychiatry 1997;63:321–6.




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