• Muhammad Tariq Khan
  • Abdul Hannan
  • Manzoor Ahmad


ABSTRACT:Bacterial activity of 98 strains of M. tuberculosis was conducted against major anti-tuberculosisdings, streptomycin, 1NH ethambutol, rifampicin & pyrazinamide Sixty-four isolates were isolatedfrom newly diagnosed cases of tuberculosis who had not started taking anti tuberculosis drugs.Thirty-four strains were isolated from patients taking anti-tuberculosis drugs from more than 02months.Therefore, this study shows both the primary as well as acquired drug resistance. In primarydrug resistance 32.8% isolates were resistant to one or more drugs. The acquired drug resistancewas very high; 67.6% isolates were resistant to one or more drugs.


N.W. Home. Drug resistant tuberculosis: A review of world situation. Tubercle 1969 Vol.50: 1-11.

Glassroth J.A.G. Robbins and D.E. Snider Jr. 1980 Tuberculosis in the 1980s . New Eng J. Med 302: 1441-

Pinching A.J.(1984). The acquired immune deficiency syndrome. Clinical Experimental Immunology,

: 1-13.

Marks J. & Leat JL (1970). Improvement of drug sensitivity test on tubercle bacilli. Tubercle, London

: 68-75.

G. Canetti et al Advances in Techniques and Testing Mycobacterial drug sensitivity and use of sensitivity

tests in tuberculosis control programmes Bull World Health Organization 1969 41,21-43.

Peter Cavanagh, Aidan B. Keyes. The use of pyruvate containing egg medium in the isolation of Tubercle

bacilli Tubercle, London (1968) 49,325-327.

M. laid Law Mycobacterium: tubercle bacilli in J.G Collee, J.P. Duguid, AG. Fraser, B P. Mamioin in Mackie

and McCartney Practical medical microbiology 13 Ed 399-414 published by Churchill Living


J.L. Leat & J. Marks improvement of Drugs Sensitivity tests on Tubercle bacilli. Tubercle, London


leading article Sensitivity tests Tubercle March 1970, 51 No.l 103-105.

Cruiek Shank, R.,Duguid, J.P.,Mannoin, B.P. & Swain RHA 1975 in Medical Microbiology 12th edition vol.2:

-205. Churchill Livingstone Edinburgh I .ondon.

Marks J.. A stepped pH technique for the estimation of Pyrazinamide Sensitivity. Tubercle 1964 45-47.

Snider D.E. Jr. et al (1981) Rapid drug susceptibility testing of M, tuberculosis. American Review of

Respiratory diseases 123:402-406.

ARH Worssan, Patrick Collard, J.D. Carrold & Robert Knox methods of determining the sensitivity of M.

tuberculosis tubercle April 1956 vol.37.

Gwyn Howells. Primary drug resistance in Australia Tubercle, -50,344-349.

Oka H Gami, J Chiba & Yanagisavva, K. Primary drug resistance to the major antituberculosis drugs in Japan.

Tubercle, London 51:152-157.

Kapnoff, D.E..Kilbern J.O., Glassroth J.L., Snider D.E., Farer, L.S. &• Good R.C. A continuing survey of

tuberculosis primary drug resistance in United States. March 1975- Nov. 1977. American review of

Respiratory diseases 118,835-842.

P.M.R.C. 1984. Annual Report 1982-1983-116.

Sensitivity tests (leading article). Tubercle London 1964, 54 169-171.

Toman K (1979). Tuberculosis case finding and chemotherapy. World Health Organization Geneva 84-93.

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