COFFEE INTAKE AND ELEVATED LIPID PROFILE IN AMI PATIENTS
AbstractCoffee intake from diet records was studied in association with serum lipid profile concentrations in a crosssectional sample of 60 middle aged men and women suffering from acute myocardial infarction to determine the significance and form of their interrelationships. All the subjects were evaluated for diabetes mellitus, nephrotic syndrome and hyper lipid - anemia. Heavy drinking of coffee revealed a highly significant (p <0.001) increase in levels of total cholesterol and LDL-cholesterol. Graphic analysis revealed that serum concentrations of total cholesterol and LDLcholesterol were positively related, which were statistically less significant (p<0.01) to intake of upto 3 cups of coffee per day and more significant (p<0.001) with intake exceeding 3-4 cups. These results suggest that heavy coffee drinking patients of acute myocardial infarction have significant increases in levels of lipoprotein profiles when compared to those faking no coffee.
Stamler J. Population studies. In: Ley RI, Ritkind
BM, Dennis BH & Ernst N (Eds). Nutrition, lipid
and coronary heart disease: a global view. Raven
Press. New York, 1979, pp 25-88.
Heiss G, Johnson NJ, Reiland S, Davis CE &
Tyroler HA. The epidemiology of plasma high
density lipoprotein cholesterol levels. The Lipid
Research Clinics Program Prevalence Study.
Circulation, 1980; 62: Suppl IV: 116- 36.
Knuiman JT, Hermus RJJ & Hautvast JGAJ.
Serum total and high density lipoprotein (HDL)
cholesterol concentrations in rural and urban boys
from 16 countries. Atherosclerosis, 1980; 36: 529-
Knuiman JT & West CE. HDL-cholesterol in men
from thirteen countries. Lancet, 1981; 2: 367-8.
Thompson GR. Dietary and pharmacological
control of lipoprotein metabolism. In: Miller NE
& Lewis B. (Eds). Metabolic aspects of
cardiovascular disease. Vol 1. Elsevier Press,
Amsterdam, 1981; pp 59-75.
Mattson FT, Erickson BA & Kligman AM. Effect
of dietary cholesterol on serum cholesterol in man.
Am J Clin Nutr. 1972; 25: 589-94.
Keys A & Parlin RW. Serum cholesterol response
to changes in dietary lipids. Am J Clin Nutr, 1966;
Hegsted DM, McGandy RB, Myers ML & Stare
FT. Quantitative effects of dietary fats on serum
cholesterol in man. Am J Clin Nutr, 1965; 17: 281-
Arab L, Kohlmeer M, Schlierf G & Schettler G.
Coffee and cholesterol. N Engl J Med, 1983; 309:
Bejelk E. Colon cancer and blood cholesterol.
Lancet, 1974; i: 1116-17.
Little JA, Shanoff HM, Csima A & Yano R.
Coffee and serum lipids in coronary heart disease.
Lancet, 1966; i: 732-34.
Fried RE, Levine PM. Kwiterorich PO, et al. The
effects of filtered coffee consumption on plasma
lipid levels. Results of a randomized clinical trial.
JAMA, 1992; 267: 811-15.
Shirlow M & Mathers C. Coffee and cholesterol.
N Engl J Med, 1983; 309: 1250.
Thelle DS, Arnesen E & Ford OH. The Tromso
heart study: Does coffee raise serum cholesterol?
N Engl J Med, 1983; 308: 1451- 57.
Kovar MG, Falwood R & Feinleih M. Coffee and
cholesterol. N Engl J Med, 1983; 309: 1249.
Dawber TR, Kannel WB & Gordon T. Coffee and
cardiovascular disease: Observations from the
Framingham study. N Engl J Med, 1974; 291: 871-
Bonaa K. Amesen E, Thelle DS & Forde OH.
Coffee and cholesterol: Is it all in the brewing?
The Tromso study. Br Med J, 1988; 297: 1103-04.
Amesen E, Ford OH & Thelle DS. Coffee and
serum cholesterol. Br Med J, 1984; 288: 1960.
Forde OH, Knursen SF, Amesen E & Thelle DS.
The Tromso Heart Study: Coffee consumption and
serum lipid concentrations in men with
hypercholesterolemia: a randomized intervention
study. Br Med J, 1985; 290: 893- 95.
Aro A, Tuomilehto J, Kostiainen E, Uusitalo U &
Pietinen P. Boiled coffee increases serum low
density lipoprotein concentration. Metabolism,
; 36: 1027-30.
Bak AAA & Grobbee DE. The effect on serum
cholesterol level of coffee brewed by filtering or
boiling. N Engl J Med, 1989; 321: 1432-37.
Superko HR, Bortz WM, Albers JJ & Wood PD.
Lipoprotein and apolipoprotein changes during a
controlled trial of caffeinated and decaffeinated
coffee drinking in man. Circulation, 1989; 80,
Suppl 11: 86.
Zock PI, Katan MB, Merkus MP, Dusseldorp MV
& Hapryvan JL. Effect of lipid rich fraction from
boiled coffee on serum cholesterol. Lancet, 1990;
Heiss G & Tyroler HA. Are apolipoprotein useh.il
for evaluating ischemic heart disease? A brief
overview of the literature, In: Lippel K (Ed.):
Proceedings of the Workshop on Apolipoprotein
quantification. Publication 83-1266, Bethesda,
Md., National Institute of Health, 1983, pp 7-22.
Kauftnann NA, Friedlander Y, Halfon ST, et al.
Nutrient intake in Jerusalem: consumption in
adults. Isr J Med Sci, 1982; 18: 1183-97.
Kaufmann NA, Friedlander Y, Halfon ST, et al.
Nutrient intake in Jerusalem: consumption in 17
years old. Isr J Med Sci, 1982; 18: 1167-8.
National Heart, Lung and Blood Institute. Manual
of laboratory' operation. Lipid Research Clinic
Programme, Vol. 1. Lipid and lipoprotein
analysis. Bethesda, Maryland. National Institute
of Health. Publication no (NIH) 75-628, (DHEW),
Richmond W. Preparation and properties of a
cholesterol oxidase from nocardia and its
application to the enzymatic assay of total
cholesterol in serum. Clin Chem, 1973; 19: 1350-
Burstein M & Scholnick HR. Lipoproteinpolyamine-metal
interaction. Adv Lipid Res,
; 2: 67-108.
Friedewald WT, Levy RI & Frederickson DS.
Estimation of low density lipoprotein cholesterol
in plasma without the use of preparative
ultracentrifugation. Clin Chem, 1972; 18: 499-
Hatch FT. Practical methods for plasma
lipoprotein analysis. Adv Lipid Res, 1968: 6: 1-68.
Fossati P & Prencipe L. Clin Chem, 1982; 28:
In: Varley’s Practical Clinical Biochemistry,
by Gowenlock AH, McMurray JR &
MacLauchlan DM. (6th ed.), Heinemann Medical
Books, London, 1988; 464-66.
Zollner N& Kirsch K. Determination of total
lipids. Ges Expt Med, 1962; 135: 545.
Sacks FM, Castelli WP, Donnor A & Kass EH.
Plasma lipids and lipoproteins in vegetarians and
controls. N Engl J Med, 1975; 292: 1148-51.